Conserved Protein Domain Family
HMG-box_NSD2
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cd21991: HMG-box_NSD2 
high mobility group (HMG)-box found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins
NSD2, also called multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1), acts as a histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness.
Links
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Statistics
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PSSM-Id: 438807
Aligned: 27 rows
Threshold Bit Score: 66.1828
Created: 8-Apr-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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putative DNA
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           ## #####  ##      #           ##  #  ##      #   #  #   #  #
O96028        452 RKGDAASQFLVFCQKHRDEVVAEHPDaSGEEIEELLRSQWSLLSEkQRARYNTKFALVAPVQ 513  human
KZC13646      355 AEEDVDGVFDVFYERNRDMMEDENPDiSENDIKEYLKKTWDSMNSsFRKKYRSCVTSDTCNT 416  Dufourea novaeangliae
RWS26986      506 KRENKKGSFTVYFSRHKQSTKQQHPKmSENEIENLLKKNWELLSEdLKANYSSPVRAKMSTT 567  Leptotrombidium deliense
OXU19769      334 KRSGKYGVFEVFCERNKESAEQLDPDaSEADIKAYLLDLWENMSSqERNKYRADYLQSDEVN 395  Trichomalopsis sarcophagae
XP_020293466  283 AIKSEEDIFEIYYQRNKELMIIEYPDtPEEEIKEYLRRTWNGMDKtFQHKYEVHLTETGSTH 344  Pseudomyrmex gracilis
XP_008558386  381 KVVEPTPSFELYYNRNKEAVANVSPDsTEDDIKTYLKKSWENMSEqARRKYIPQVNGHSKQS 442  Microplitis demolitor
XP_027221327  939 TKLSKEGSFKVYAQKHLPKIMQDFPNiSEETARNKLRWRWKKMSSsQTTRYKSKFSSSQNEG 1000 Pacific white shrimp
XP_022091753  641 KRGRKSFQYLAFCSKHTEELTSQHPDkSKVEINALLEDKWEEMTEeEKAKYGTSPARATPAT 702  crown-of-thorns starfish
KPM03216      328 RKRLPKGDFSVYCKKHYDEEAKKDPNlSKNEINRLLKEKWSNLDEeMRSLYVKRKAIDEDDF 389  Sarcoptes scabiei
XP_001310689    4 SNFNQMDAFTLFCYKNREMVMTQNPNlPVLEVNNKLNEMWMNLSDsERMQYTEAAASNNQQK 65   Trichomonas vaginalis G3

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