5AAS,5YT6,4Z4M,4Z4K,4BMJ


Conserved Protein Domain Family
Zn-C2H2_TAX1BP1_rpt2
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cd21970: Zn-C2H2_TAX1BP1_rpt2 
second C2H2-type zinc binding domain found in tax1-binding protein 1 (TAX1BP1) and similar proteins
TAX1BP1, also called TRAF6-binding protein (T6BP), is a novel ubiquitin-binding adaptor protein involved in the negative regulation of the NF-kappaB transcription factor, a key player in inflammatory responses, immunity and tumorigenesis. It inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. It may also play a role in the pro-inflammatory cytokine IL-1 signaling cascade. TAX1BP1 is degraded by caspase-3-like family proteins upon TNF-induced apoptosis. TAX1BP1 contains two C2H2-type zinc binding domains; this model corresponds to the second one.
Links
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Statistics
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PSSM-Id: 412016
Aligned: 13 rows
Threshold Bit Score: 46.3943
Created: 27-May-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding site
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:C C H HClick to see conserved feature residue pattern help
Evidence:
  • Structure:5AAS; Homo sapiens TAX1BP1 binds a Zn2+ ion through its second C2H2-type zinc binding motif
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          #  #               #   # 
5AAS_A        35 KVCPMCSEQFPPDyDQQVFERHVQTHF 61  human
5YT6_F         3 KVCPMCSEQFPPDyDQQVFERHVQTHF 29  human
4Z4M_A       234 KVCPMCSEQFPPDyDQQVFERHVQTHF 260 Aequorea victoria
4Z4K_A       264 KVCPMCSEQFPPDyDQQVFERHVQTHF 290 Aequorea victoria
4BMJ_A        35 KVCPMCSEQFPPDyDQQVFERHVQTHF 61  human
NP_990069    782 KVCPMCSEQFPPDyDQQGFERHVQTHF 808 chicken
Q86VP1       755 KVCPMCSEQFPPDyDQQVFERHVQTHF 781 human
XP_005994362 744 KVCPMCNEQFSPDcDQHIFESHVLRHF 770 coelacanth
XP_007898671 812 KVCPMCNEQFSPDcDQQIFEKHVLMHF 838 elephant shark
NP_989247    807 KVCPMCNEQFPPDcDQQIFERHVQTHF 833 tropical clawed frog
Q1LWB0       744 RVCPVCSEQFPLDcQQQLYEKHVHTHF 770 zebrafish
Q6P132       790 KICPMCSEQFPLDcDQQLFEKHVLTHF 816 zebrafish
XP_019857108 395 RQCPMCNKTFPPAtSQRNFELHVDTHL 421 Amphimedon queenslandica

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