Conserved Protein Domain Family

cd21965: Zn-C2H2_CALCOCO1_TAX1BP1_like 
autophagy receptor zinc finger-C2H2 domain found in calcium-binding and coiled-coil domain-containing proteins, TAX1BP1 and similar proteins
The family includes calcium-binding and coiled-coil domain-containing proteins (CALCOCO1 and CALCOCO2), TAX1BP1 and similar proteins. CALCOCO1, also called calphoglin, or coiled-coil coactivator protein, or Sarcoma antigen NY-SAR-3, functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). CALCOCO2, also called antigen nuclear dot 52 kDa protein, or nuclear domain 10 protein NDP52, or nuclear domain 10 protein 52, or nuclear dot protein 52, is an ubiquitin-binding autophagy receptor involved in the selective autophagic degradation of invading pathogens. TAX1BP1, also called TRAF6-binding protein (T6BP), is a novel ubiquitin-binding adaptor protein involved in the negative regulation of the NF-kappaB transcription factor, a key player in inflammatory responses, immunity and tumorigenesis. The family also includes Drosophila melanogaster Spindle-F (Spn-F) that is the central mediator of IK2 kinase-dependent dendrite pruning in drosophila sensory neurons. This model corresponds to the C2H2-type zinc binding domain found in family members. It is a typical C2H2-type zinc finger which specifically recognizes mono-ubiquitin or poly-ubiquitin chain. The overall ubiquitin-binding mode utilizes the C-terminal alpha-helix to interact with the solvent-exposed surface of the central beta-sheet of ubiquitin, similar to that observed in the RABGEF1/Rabex-5 or POLN/Pol-eta zinc finger.
PSSM-Id: 412012
Aligned: 11 rows
Threshold Bit Score: 31.0026
Created: 23-Apr-2019
Updated: 25-Oct-2021
Aligned Rows:
Zn binding site
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:C C [CH] [CH]Click to see conserved feature residue pattern help
  • Structure:2MXP; Homo sapiens CALCOCO2 binds a Zn2+ ion through its C2H2-type zinc binding domain.
    View structure with Cn3D

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Feature 1         #  #               #   #
4Z4K_A        239 CPLCELMFPpnydqsKFEEHVESH 262  Aequorea victoria
2MXP_A          9 CPICDKIFPate-kqIFEDHVFCH 31   human
5AAS_A         10 CPLCELMFPpnydqsKFEEHVESH 33   human
5AAS_A         37 CPMCSEQFPpdydqqVFERHVQTH 60   human
XP_030856285  991 CPVCQGLLDpqisqiDFQKHVECC 1014 purple sea urchin
XP_013393304  605 CPSCNRVFPvsmpmeELQQHVMDC 628  Lingula anatina
Q9P1Z2        656 CPICKERFPaesdkdALEDHMDGH 679  human
NP_001263138  313 CPMCGKQYSsqvsfnAFREHVEMH 336  fruit fly
RUS76780      913 CPVCNARFElsvpqtEFERHVHSH 936  eastern emerald elysia
ELU03518      838 CPICHHQFEkgvdqeMFQVHVENH 861  Capitella teleta
XP_028132366  297 CPVCRQQFEdevkfeIFEDHVNSH 320  western corn rootworm

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