6JLE


Conserved Protein Domain Family
MBD_Myo3a
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cd21956: MBD_Myo3a 
Click on image for an interactive view with Cn3D
MORN4 binding domain (MBD) found in Myosin-IIIa and similar proteins
Myosin-IIIa, also called Myo3a, is a probable actin-based motor with ATPase and kinase activities. It may function as a cellular transporter capable of moving along actin bundles in sensory cells. Myosin-IIIa is highly expressed in retina and in inner ear hair cells. It is localized to the distal ends of actin-bundled structures. It is required for normal cochlear hair bundle development and hearing, and plays an important role in the early steps of cochlear hair bundle morphogenesis. Mutations in human myosin-IIIA are responsible for progressive nonsyndromic hearing loss. This model corresponds to the MORN4 binding domain (MBD) in the tail of myosin-IIIa. MORN4 and its Drosophila ortholog retinophilin (RTP) are binding partners/cargos of class III myosins.
Links
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Statistics
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PSSM-Id: 439318
Aligned: 10 rows
Threshold Bit Score: 69.0256
Created: 13-Oct-2021
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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MORN4 binding
Conserved site includes 28 residues -Click on image for an interactive view with Cn3D
Feature 1:MORN4 binding site [polypeptide binding site]
Evidence:
  • Structure:6JLE; Homo sapiens Myo3a in complex with MORN4, contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  #  #  ### ###### ### ## ## ######   ####
6JLE_E          2 SDNKDSKATSEREACGLAIFSKQISKLSEEYFILQKKLNEMILSQQLKS 50   human
Q8NEV4       1409 KDNKDSKATSEREACGLAIFSKQISKLSEEYFILQKKLNEMILSQQLKS 1457 human
XP_025004137 1523 ESSKTLKGGSEKETCDLAAFSRQISKLSEDYLALQQKLNEMILSHQLRP 1571 chicken
XP_007899427 1462 KERKQIQQCTEREAQDLATFSKQITKHSDEFLTMQQKLNEVIASHLLKP 1510 elephant shark
XP_018122734 1406 KNTENETLSVLKEIEDLAVFTDEISKLSEKYLILQQALNEMIMLNLLKP 1454 African clawed frog
XP_014350789 1320 KERKNLKDTCATHSKVLASFTSQISKASAKYLTVQEKLCDTISSQQLKP 1368 coelacanth
XP_007504910 1424 RDEKDLKTITEKEAFELAVFSKQISKLSEDYFILQKKLNEIILLHRLKP 1472 gray short-tailed opossum
Q8K3H5       1406 VDERDSKMASKKEAWDLAMFSRQISKLSEEYFILQKNLNEIILAQQLKP 1454 house mouse
NP_991142    1562 KDRKNLKATSQKQDEEVESLFKQVSKASEDYLSLQKKLNEIILAHQLNP 1610 Danio rerio
XP_011517807 1409 KDNKDSKATSEREACGLAIFSKQKSIQEEKRRPRKDSQGKLLDLEDFYY 1457 human

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