2KJY


Conserved Protein Domain Family
IPD_PPP1R12

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cd21930: IPD_PPP1R12 
inhibitory phosphorylation domain of protein phosphatase 1 regulatory subunit 12 (PPP1R12) family
The PPP1R12 family includes PPP1R12A/MYPT1, PPP1R12B/MYPT2, and PPP1R12C. PPP1R12A/MYPT1, also called myosin phosphatase target subunit 1, or protein phosphatase myosin-binding subunit, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH). It acts as a key regulator of protein phosphatase 1C (PPP1C). It mediates binding to myosin. As part of the PPP1C complex, PPP1R12A/MYPT1 is involved in dephosphorylation of PLK1. It is capable of inhibiting HIF1A inhibitor (HIF1AN)-dependent suppression of HIF1A activity. PPP1R12B/MYPT2, also called myosin phosphatase target subunit 2, is the targeting subunit of smooth-muscle myosin phosphatase that regulates myosin phosphatase activity and augments Ca(2+) sensitivity of the contractile apparatus. PPP1R12C, also called protein phosphatase 1 myosin-binding subunit of 85 kDa (MBS85), protein phosphatase 1 myosin-binding subunit p85, or LENG3, regulates myosin phosphatase activity. All family members contain an inhibitory phosphorylation domain.
Statistics
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PSSM-Id: 412018
Aligned: 23 rows
Threshold Bit Score: 40.7883
Created: 30-Sep-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2KJY_A          9 RERRRSYLtPVRDEESESQRKARSRQARQSRRSTQg-------VTLTDLQEAEK 55   human
ELT90127      596 TGQRRSFEpPKRDEEKEVERKAKAKRARESRRSTQarisphhgVTKEDLEKAEQ 649  Capitella teleta
VDO93329      752 VMRDRVFSpPNRSEESEAERKMRAKKERESRRSTQr-------APDFDSFSHGS 798  Soboliphyme baturini
XP_030850006  602 PSSRRSIMtPSKEEESETQRKARAKRERSSRRSTQg-------VSAEDIESAVK 648  Strongylocentrotus purpuratus
XP_018645718  599 NRRISVVMaPTKSGETETQRSVKARYVRSTRRSTQg-------VSSEDVEQAKK 645  Schistosoma mansoni
NP_495994     652 TFSKPSRWqSKTVTESEAERRNNSRMQRQHRRSTQg-------VTKEQLEEASK 698  Caenorhabditis elegans
OTF73709      162 ELIEVTKEkEKIAKESETQRKIFAKRQREQRRSTQg-------VNREDLEQALK 208  Euroglyphus maynei
TMS35500      696 RSWQTPPMqPSQKDEREAERKAKSRMQRATRRSTQa-------ITTEDLNSARS 742  Steinernema carpocapsae
VDD92298      588 VSLLTPPTePNFLKESEAERRSKAKRQRDSRRSTQg-------VTKEQIKAASL 634  human pinworm
XP_014672574  539 TRPIRSLQpPSPDDEAETVRRSKSRLARQTRRSTQg-------ITAEDVAEAQA 585  Priapulus caudatus
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