5IXI


Conserved Protein Domain Family
JAK1bd_box_IL10RA
?
cd21909: JAK1bd_box_IL10RA 
Click on image for an interactive view with Cn3D
JAK1 binding box domain found in interleukin-10 receptor subunit alpha (IL10RA) and similar proteins
IL10RA, also called IL-10 receptor subunit alpha, IL-10R subunit alpha, IL-10RA, CDw210a, interleukin-10 receptor subunit 1, IL-10R subunit 1, or IL-10R1, is a cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. This model corresponds to IL10RA box domain which consists of box1 and box2.
Links
?
Statistics
?
PSSM-Id: 439314
Aligned: 3 rows
Threshold Bit Score: 92.9196
Created: 18-May-2020
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
JAK1 binding
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:JAK1 binding site [polypeptide binding site]
Evidence:
  • Structure:5IXI; Homo sapiens IL10RA in complex with JAK1, contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1           ## ##### ## ###### #                             
5IXI_B         2 SKTLMGNPWFQRKKLPSVLLFKKPSPFIFISQRPSPETQDTIHPLDEEAFLK 53  human
Q13651       252 YCLALQLYVRRRKKLPSVLLFKKPSPFIFISQRPSPETQDTIHPLDEEAFLK 303 human
XP_003820111 252 YCLALQLYVRRRKKLPSVLLFKKPSPFIFISQRPSPETQDTIHPLDEEAFLK 303 pygmy chimpanzee

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap