6BN1


Conserved Protein Domain Family
SARAH_Hpo
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cd21889: SARAH_Hpo 
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C-terminal SARAH domain of Drosophila melanogaster protein Hippo (Hpo) and similar proteins
Hpo, also called STE20-like kinase MST (dMST), is the Drosophila homolog of STE20-like protein kinases, MST1 and MST2. It is a STE20 family serine/threonine-protein kinase that functions as a tumor suppressor by restricting cell proliferation, and promotes apoptosis in conjunction with salvador and warts. Hpo plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. This model corresponds to the C-terminal SARAH (Salvador-RassF-Hippo) domain of Hpo, which mediates complex formation between Hpo and Sav, as well as homodimerization.
Links
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Statistics
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PSSM-Id: 439183
Aligned: 6 rows
Threshold Bit Score: 88.7669
Created: 2-Jun-2020
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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dimer interface
Conserved site includes 30 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:SARAH domain-containing proteins can form both homo- and heterodimers
  • Structure:6BN1; Drosophila melanogaster Hippo in complex with Sav through their SARAH domains, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         ##  ## ###  ## ##  ## ##  ##  ## ## ### ##  ##  ##      
6BN1_A         1 GEFEFLKFLTFDDLNQRLCNIDHEMELEIEQLNKKYNAKRQPIVDAMNAKR-KRQQN 56  fruit fly
Q175W2       536 SEYDSLKFLNYEQLEQRLASIDKEMEKELAETNKRYHAKRKPIIDAIEAKQqKRQQK 592 yellow fever mosquito
Q8T0S6       606 GEFEFLKFLTFDDLNQRLCNIDHEMELEIEQLNKKYNAKRQPIVDAMNAKR-KRQQN 661 fruit fly
XP_001950941 485 GDFDFLKFLSFDDLQQRMSNLDSEMEHEIDELRRRYQTKRQPILDAMDQKR-KRQQN 540 pea aphid
ROT79885     591 GDFDFLKNLTYEELHQRMATLDQEMEREIDELRQRYHAKRQPILDAMDQKR-KRQQN 646 Pacific white shrimp
GBM89038     482 GNFDFLKGLSYAELNQRMASLDSEMERDIEELRRRYQAKRQPILDAMGAKK-KRQQN 537 Araneus ventricosus

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