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C-terminal SARAH domain of mammalian STE20-like protein kinase 2 (MST2) MST2, also called serine/threonine-protein kinase 3, MST-2, STE20-like kinase MST2, or serine/threonine-protein kinase (STK) Krs-1, is a STE20 family stress-activated, pro-apoptotic STK which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. It is a key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. This model corresponds to the C-terminal SARAH (Salvador-RassF-Hippo) domain, which mediates homodimerization of MST2. Similar to MST1, MST2 may also form heterodimers with other SARAH domain-containing proteins.
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Jiyao W et al.(2023). "The conserved domain database in 2023.",