2JO8,4NR2


Conserved Protein Domain Family
SARAH_MST1
?
cd21887: SARAH_MST1 
Click on image for an interactive view with Cn3D
C-terminal SARAH domain of mammalian STE20-like protein kinase 1 (MST1)
MST1, also called serine/threonine-protein kinase 4, MST-1, STE20-like kinase MST1, or serine/threonine-protein kinase (STK) Krs-2, is a STE20 family stress-activated, pro-apoptotic STK which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. It is a key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. This model corresponds to the C-terminal SARAH (Salvador-RassF-Hippo) domain, which mediates homodimerization of MST1. The MST1 SARAH domain also interacts with Rassf1 and Rassf5 by forming a heterodimer which mediates the apoptosis process.
Links
?
Statistics
?
PSSM-Id: 439181
Aligned: 8 rows
Threshold Bit Score: 77.6359
Created: 2-Jun-2020
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
dimer interface
Conserved site includes 32 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Comment:SARAH domain-containing proteins can form both homo- and heterodimers
  • Structure:2JO8; Homo sapiens Mst1 SARAH domain forms a homodimer, contacts 4A
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1         ## ######  ## ##  ## ##  ##  ## ##  ## ###### ##
2JO8_B         3 DYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAK 51  human
Q6P3Q4       430 DYSFLKDWSVTELQLRLNSLDPMMEQEIEEIHHKYQAKRQPILEAIESK 478 tropical clawed frog
XP_006006895 433 DYEFLKNWSVDDLQQRLASLDPMMEREIEEIRQRYDSKRQPILDAIEAK 481 coelacanth
XP_022541044 408 DMELMRSWSVEELKRRLASLDPQMEQEIEEIRQRYQTKRQPILDAIEAK 456 Mexican tetra
Q5ZJK4       431 DYEFLKTWSVDELQRRLSALDPMMEQEIEEIRQKYQSKRQPILDAIEAK 479 chicken
XP_007910078 434 DFEFLKGWSVEELQRRLASLDPMMEQEIEEIRQRYQAKRQPILDAIDAK 482 elephant shark
4NR2_A         3 DYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAK 51  human
Q13043       432 DYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAK 480 human

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap