1ADQ


Conserved Protein Domain Family
IgC1_CH1_IgM

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cd21819: IgC1_CH1_IgM 
Click on image for an interactive view with Cn3D
CH1 domain (first constant Ig domain of the heavy chain) in immunoglobulin heavy mu chain; member of the C1-set of Ig superfamily (IgSF) domains
The members here are composed of the first immunoglobulin constant-1 set domain of mu chains. It belongs to a family composed of the first immunoglobulin constant-1 set domain of alpha, delta, epsilon, gamma, and mu heavy chains. This domain is found on the Fab antigen-binding fragment. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda; each is composed of a constant domain and a variable domain. There are five types of heavy chains: alpha, delta, epsilon, gamma, and mu, all consisting of a variable domain (VH) with three (alpha, delta and gamma) or four (epsilon and mu) constant domains (CH1 to CH4). Ig molecules are modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. This group belongs to the C1-set of IgSF domains, which are classical Ig-like domains resembling the antibody constant domain. C1-set domains are found almost exclusively in molecules involved in the immune system, such as in immunoglobulin light and heavy chains, in the major histocompatibility complex (MHC) class I and II complex molecules, and in various T-cell receptors.
Statistics
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PSSM-Id: 409624
Aligned: 17 rows
Threshold Bit Score: 115.504
Created: 14-May-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Comment:Dimerization of Ig domains from different chains is common, but not found in all members.
  • Structure:1ADQ; human IgM Fab, heavy and light chain -IgC interface, based on 4A distance
    View structure with Cn3D
  • Citation:PMID 9145108

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #####           #    # #                           ######     ### #         
1ADQ_H    128 APTLFPLVS--CENSnpsSTVAVGCLAQDFLPDSITFSWKyk-nNSDis--stRGFPSVLR-GGKYAATSQVLLPSKDvm 201 human
AAO52809  133 APTVFPVAS--CSEPspdGFISLGLLATEFLPNDVSFTWRsq-pSIDaslflpKTYPSVISaKGTYIGSSQLLLPFTEcq 209 marbled lungfish
A46532      5 APSVYPLIS--CGASl--DPVVIGCLAKGFLPDSVTFDWTdk-nNASfsa-gvAKLPSVTT-GGLYSASTRVKVPSESwk 77  axolotl
AAC59687   10 APTLFPLVP--CGSGasvDPVSVGCLATGFSPDSLTFGWSe--gSKElt--nfQKYPSVLGsGGLYSMTSQLSIPKADwe 83  bowfin
AAC12893   80 PPSLYALLPs-CGPStsrGSVTFWCLATNYNPEPATFSWTsn-gRSItd--qvKTYPSVLNkNGLYTLSSQLTIAESQm- 154 spotted ratfish
AAB04671    4 APSLFILFT--CEDHgssGSFTYGCLVLGYSPAGASVSWKkd-dKQLtt--gvKDYPAVFNkLGTYTRSSELTIAEAEa- 77  little skate
AAV28075    4 APTLFPLAQ--CGSGt-gDMMTLGCIATGFTPASLTFKWNeqggNSLtd---fVQYPAVQT-GGSYTGVSQLRVKRADw- 75  brown trout
CAA73703  143 PPTVFPLMEscCLSDi-sGPVATGCLATGFLPTPATFSWTdqsgKAFqtd-ksLQYPPVQT-EGTYTSTGQLAISDAEwq 219 Siberian sturgeon
A34891    141 SPTVFPLVS--CGATs--GYVTMGCIGKGYLPDSLTFSWSkd-sTDLtd---yLQYPSVLS-GGKYDRVSHARVTEGDfk 211 ladyfish
AAY42141  145 SPTLFPLVQ--CNSGp-aDKITVGCLARDFYPKSLTFQWTnssgTALt----sENYPPAEK-NNKYTGVSLVQVSKSDwd 216 Chinese perch
Feature 1                               
1ADQ_H    202 qgtNEHVVCKVQHp--nGNKEKDVPL 225 human
AAO52809  210 --kPNNIFCEVKH----SLCTKEYPV 229 marbled lungfish
A46532     78 --nRDPYYCKVTHpslgQPLTKKVQF 101 axolotl
AAC59687   84 -nkDKMFYCKATNp--sGTASAELKP 106 bowfin
AAC12893  155 --dNSNIRCKVKSss-wPDVDIPLPV 177 spotted ratfish
AAB04671   78 --gRGDIVCVVQHd--qKEYETPLPD 99  little skate
AAV28075   76 --dSKIFECAVEHs--aGSKTVPVKK 97  brown trout
CAA73703  220 --kAEYFYCTVENa--sGKNKVKVAK 241 Siberian sturgeon
A34891    212 --sKAEFKCTTEL----GGKKTPVVI 231 ladyfish
AAY42141  217 --sRKSFKCSVHHn--gSTHDLQVHK 238 Chinese perch

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