Conserved Protein Domain Family

cd21803: CEN_USH1G 
central domain found in usher syndrome type-1G protein
Usher syndrome type-1G protein (USH1G), also called scaffold protein containing ankyrin repeats and SAM domain (Sans), is an anchoring/scaffolding protein that is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A, that mediates mechanotransduction in cochlear hair cells. It is required for normal development and maintenance of cochlear hair cell bundles, as well as for normal hearing. USH1G consists of four N-terminal ANK repeats, a central region, and a sterile alpha motif (SAM) followed by a C-terminal type I PDZ binding motif (PBM). This model corresponds to the central region (CEN) of USH1G, which contains the conserved regions CEN1 and CEN2. CEN is directly responsible for binding to the MYO7A MyTH4-FERM tandem.
PSSM-Id: 409642
Aligned: 7 rows
Threshold Bit Score: 78.7352
Created: 20-Apr-2020
Updated: 25-Oct-2021
Aligned Rows:
myosin tail
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:myosin tail binding site [polypeptide binding site]
  • Comment:CEN domains bind to myosin tail homology 4-protein 4.1, ezrin, radixin, moesin (MyTH4-FERM) domains in the myosin tail
  • Structure:3PVL; Homo sapiens USH1G in complex with Myosin VIIa MyTH4-FERM-SH3, contacts at 4A
    View structure with Cn3D

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Feature 1                 ################                                                       
3PVL_B         2 EVSTDSGHDSLFTRPGLGTMVFRRNYLSSGLHGLGREDggldgvgaprgrlqssps-----ldddslgsanslqdrscgE 76  human
XP_007886944 294 EISTDSGHESLFNRPGLGTMVFRRNYVTGGLFGLGLEQegglmdsssgagvrlrsrl---hrspslsesigsagslqggS 370 elephant shark
XP_426242    299 EVSTDSGHESLFNRPGLGTMVFRRNYVSSGLFGIGREDagvlgegnadgaglklrgrlqrspslndsigsanslqernaE 378 chicken
XP_005998319 299 EVSTDSGHDSLFNRPGLGTMVFRRNYVSGGLFGIGQDDssmigdhvmhtrgvklrsrlqrspslndsigsanslqerniE 378 coelacanth
XP_002661315 303 EISTDSGHDSLFNRPGLGTMVFRRNYVSGGLFGIGSRDegsltgservdnvrlqnrmh--psldddsigsahslqerniQ 380 zebrafish
Q495M9       296 EVSTDSGHDSLFTRPGLGTMVFRRNYLSSGLHGLGREDggldgvgaprgrlqssps-----ldddslgsanslqdrscgE 370 human
XP_018090803 297 EVSTDSGHDSLFTRPGLGTMVFRRNYLSSGLFGMGRDEgnglqtgvgeeiklrsrlkr--spslddsigsagslvvrndQ 374 African clawed ...
Feature 1                          
3PVL_B        77 ELPWDELDLGLDEDLEPE 94  human
XP_007886944 371 GPSWELGELELDSDMDTS 388 elephant shark
XP_426242    379 ELPWDEVELGLDDDDEPD 396 chicken
XP_005998319 379 DLPWDEVDLGLDNDDEPE 396 coelacanth
XP_002661315 381 ELPWDEVELGLDDDDEPD 398 zebrafish
Q495M9       371 ELPWDELDLGLDEDLEPE 388 human
XP_018090803 375 ELPWEEEDLRLDDDEEPD 392 African clawed frog

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