Conserved Protein Domain Family

cd21802: CEN_ANKS4B 
central domain found in ankyrin repeat and SAM domain-containing protein 4B
Ankyrin repeat and SAM domain-containing protein 4B (ANKS4B), also called Harmonin-interacting ankyrin repeat-containing protein (Harp), is highly expressed in intestine and is essential for intermicrovillar adhesion. As part of the intermicrovillar adhesion complex (IMAC), ANKS4B plays a role in epithelial brush border differentiation, controlling microvilli organization and length. It may be involved in cellular response to endoplasmic reticulum stress. ANKS4B consists of four N-terminal ANK repeats, a central region, and a sterile alpha motif (SAM) followed by a C-terminal type I PDZ binding motif (PBM). This model corresponds to the central region (CEN) of ANKS4B, which contains the conserved regions CEN1 and CEN2. CEN is directly responsible for binding to the N-terminal MyTH4-FERM-SH3 supramodule of MYO7B, with a mechanism highly analogous to the interaction between USH1G and MYO7A.
PSSM-Id: 409641
Aligned: 5 rows
Threshold Bit Score: 51.3473
Created: 20-Apr-2020
Updated: 25-Oct-2021
Aligned Rows:
myosin tail
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:myosin tail binding site [polypeptide binding site]
  • Comment:CEN domains bind to myosin tail homology 4-protein 4.1, ezrin, radixin, moesin (MyTH4-FERM) domains in the myosin tail
  • Structure:5F3Y; Mus musculus ANKS4B in complex with MYO7B, contacts at 4A
    View structure with Cn3D

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Feature 1                 ##  ## ######                                                          
5F3Y_B         4 EEDDDVQHESILNRPGLGSIVFSRNRVldfedisdskrelgfkmpselfqrqgaagtveeeeeeeeeeeeekreangtAG 83  house mouse
XP_001366705 260 DENRDVQQESIFNRPGLGNMVFRRNTAledisgskrevefnivsgllq----------rggsgntgetdpdaeieeedED 329 gray short-tail...
NP_001002188 265 DEEGAGKGKSIFERPGLGKMVFRRNFSmemamdpedlpigntedlgy------------lirqelfetvdeglegldeDA 332 zebrafish
Q8N8V4       255 EEDGSVHHESILNRPGLGSIVFRRNRIsspedisdskrefgfklpsell-------qrqgaseadegaadeegeenglKD 327 human
TFK02107     259 EDDSKQEHVSIFKRPGLGNIVFRRNLSaginaeekeeisfkmpte----------------lfrheraesaseldtenDF 322 big-headed turtle
Feature 1                         
5F3Y_B        84 DLPWDEEEVEWEEDAVD 100 house mouse
XP_001366705 330 DMPWNENEVEWEEDEAD 346 gray short-tailed opossum
NP_001002188 333 ELPWNEEEIGLNEEEEE 349 zebrafish
Q8N8V4       328 DLPWDDDEVEWEEDVVD 344 human
TFK02107     323 DVPWNEDEIGWDDDEAE 339 big-headed turtle

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