Conserved Protein Domain Family
Rad21_Rec8_M_ScRec8p-like
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cd21790: Rad21_Rec8_M_ScRec8p-like 
Middle HEAT-repeat binding domain found in Saccharomyces cerevisiae meiotic recombination protein Rec8 (ScRec8p) and similar proteins
ScRec8p, also called cohesin REC8, or sporulation protein 69, replaces the SCC1 mitosis-specific cohesin to ensure sister chromatid cohesion during meiosis. It is cleaved by ESP1 shortly before the first meiotic division, and dissociates from chromatin, allowing sister chromatids to segregate. It is protected from cleavage by SPO13. This model corresponds to a small region in the middle of ScRec8p that shows high sequence similarity with the HEAT-repeat binding domain of Saccharomyces cerevisiae sister chromatid cohesion protein 1 (ScScc1p) and Homo sapiens nuclear matrix protein 1 (NXP-1), which consists of short helices and two long extended segments.
Links
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Statistics
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PSSM-Id: 439292
Aligned: 45 rows
Threshold Bit Score: 67.6828
Created: 22-Apr-2020
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Download Cn3D
 
putative
Feature 1:putative HEAT-repeat binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structure of human Scc1 in complex with HEAT-repeat containing protein Stromal Antigen 2 (SA2)
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              ###########  #  ##                                 ########               
Q12188       574 LDYQTKKFYDYIKERSIVVGRTTRSnppfk---------------------rkmllVDIIPSRMGeaqtganfddvergv 632 Saccharomyces c...
XP_028479073 596 LDSQCRHFFSYLETRMVEAQTDEIEl------------------------------THILPAGAT--------------- 630 Apiotrichum por...
OWZ62113     624 LEKQCRDFFSYVEKRMLTLDKQEVEf------------------------------NELVPEKSS--------------- 658 Cryptococcus ne...
ODN93595     626 LEKQCRDFFIYIEKRMVALQKENVEf------------------------------EELVPITSG--------------- 660 Cryptococcus de...
XP_001387885 499 NHTKLLKFHQLIQSRTRTYGNLYENvhrenttfsqpfgi---gsttnegqyytikfSDLIPSRSKtineel-----eipi 570 Scheffersomyces...
XP_020079086 524 LNKGLTNFVQYMIKRSEEFATTISEeeilnkrlkiprviqdnflendegnyhkirmSDLIPAKSVhv------------- 590 Hyphopichia bur...
RXK41483     633 LEKQCRDFFSFVETKMIEVDSDQITf------------------------------EDVSPQGIK--------------- 667 Tremella mesent...
PTB74321     546 LDVTSQNFLEYATEQAEKTGVTHSRdprnrr--------------------wiefeELADPSTHT--------------- 590 Trichoderma lon...
THH01821     359 LERNSFNFMEYAKMQINAFPSAASAlr----------------------------fEDIVPADSSt-------------- 396 Phlebia centrifuga
XP_002485379 535 LDNNDRNFLDYLQTRVQGTKVGRDSpgiq-----------------------kisfSELLPPTSTs-------------- 577 Talaromyces sti...

Feature 1                #  ######                     ## ######
Q12188       633 sRQIAASAFLSLLNLATKGMVKLNEypvadavtkdlkLRREDEIIVY 679 Saccharomyces cerevisiae S288C
XP_028479073 631 -KRVAAAAFYNCLNLATKRILSLSQd----------eHCGPIGIRIA 666 Apiotrichum porosum
OWZ62113     659 -KHIAAVAFYDCLTLATKKILTINQ------------PEPWEDINIQ 692 Cryptococcus neoformans var. grubii
ODN93595     661 -KHIAAIAFYDCLTLATKKVVNVHQ------------LESWGEIDVE 694 Cryptococcus depauperatus CBS 7855
XP_001387885 571 tRTLAANSFASILALATNDMVGIYVspqas---dsygILSGEAIDII 614 Scheffersomyces stipitis CBS 6054
XP_020079086 591 nRGKASLAFVSVLELATRDFMVIETdqdd-----pvnLLKGDHISLC 632 Hyphopichia burtonii NRRL Y-1933
RXK41483     668 -KHVAALAFYNCLTLATKHIVRVVQ------------EVDYGGFVIS 701 Tremella mesenterica
PTB74321     591 -KAIAAQAFLHVLSLATKNVVSVRQdgva-----amqPFGTLRIGIK 631 Trichoderma longibrachiatum ATCC 18648
THH01821     397 -RRVAATAFYHCLVLATKDLLRVEQk----------ePYGALAIAIK 432 Phlebia centrifuga
XP_002485379 578 -RAVATQALLHVLTLATKNVIQVSQgkrcr--gapyaIDDLHEIRLS 621 Talaromyces stipitatus ATCC 10500

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