Conserved Protein Domain Family
Rad21_Rec8_M_SpRec8p-like
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cd21789: Rad21_Rec8_M_SpRec8p-like 
Middle HEAT-repeat binding domain found in Schizosaccharomyces pombe meiotic recombination protein Rec8 (SpRec8p) and similar proteins
SpRec8p, also called cohesin rec8, is involved primarily in the early steps of meiotic recombination. It is required to ensure reductional chromosome segregation. This model corresponds to a small region in the middle of SpRec8p that shows high sequence similarity with the HEAT-repeat binding domain of Saccharomyces cerevisiae sister chromatid cohesion protein 1 (ScScc1p) and Homo sapiens nuclear matrix protein 1 (NXP-1), which consists of short helices and two long extended segments.
Links
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Statistics
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PSSM-Id: 439291
Aligned: 58 rows
Threshold Bit Score: 51.6889
Created: 22-Apr-2020
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Download Cn3D
 
putative
Feature 1:putative HEAT-repeat binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structure of human Scc1 in complex with HEAT-repeat containing protein Stromal Antigen 2 (SA2)
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           ###      ########  #  ##           ########                            #  #
P36626     284 KRRKVQKLle---pDENIELSTRTLSQWRKNYvERMIALEATKYVRRRGASsakk---------------kelNKFFDWE 345  Schizosaccharomy...
KKA31191   318 RPRSTRRIdf---vDDDISIPSATIKAQFQEYiALHDSLAARKHALSTARSskrvgaaf------vfergigaVGAAYCT 388  Thielaviopsis pu...
POS85903   299 RVKTKKTIi----iDESIELDNFDMRKMAAEYhKSMTDQAWLKNRAKEISAskknahfyi----fgtginnigKDVGLSN 370  Erysiphe pulchra
TQS38740   328 KARKNVTIt-----DICTELETADMRKMAVEYcANMTTQLKLKARSKEIMAskkkafhyi----fgvgingvgEIEGLYR 398  Golovinomyces ma...
KKF96681   368 RTRAPNHVsl---lDEDTRLHMDSIRAMSQNYlDIQEDLTVKKKRRMVARNskanalkf------vfghgighVGSVDSM 438  Ceratocystis pla...
TDZ61739   673 KKRRRVTMa----fDKDTSISIAIVKNWQTDYaEHNERLNGRKRRKVTIVEardnayhlv----lgrglfnvgDREGATG 744  Colletotrichum t...
SZF00776   315 RPRRPKTRknfataDVMTELGNSEISRMMSDYpENMQQQSLLKTRAKVQGEskrvayhy------vfgyginsIGQARHS 388  Blumeria gramini...
ODA83247   326 CRRKVNTLi-----DTVTQISRSDYRNLSDTYvDRMKSAAARKRTKALMATtqvrakkhalaflfgnriarvgDARNLSG 400  Drechmeria conio...
CDR39169   401 KAKRAKLIp----iDRSTELTDDQFRSMRATYaERMEAERKKADKAREEREahqka-------------mdaiFGVPAAF 463  Rhodotorula toru...
VBB72948   308 RQRRRQLLa----pDDQTMLTRGRIRLWGDTYaNRADEETARQQRRGLTATetrmnaynlv---fgqglanlgYLAGYPN 380  Podospora comata

Feature 1      #####                                         ## ######    
P36626     346 SFHPLLKPWIeklkpsn-----------------ntpseiDDVLRNIDTSEVEVGRDVQ 387  Schizosaccharomyces pombe 972h-
KKA31191   389 MQHPLAPLFAgplflatlvngrtp---tapapagvtqallRTDEEVLMDIDAEDARRMP 444  Thielaviopsis punctulata
POS85903   371 AINSLATFSGealherilgs----------yttpllehgrKRSQSESEFDEKSMNKRAR 419  Erysiphe pulchra
TQS38740   399 LENPLASFSGqdlqakilggs---------atsssqkyerKRARSEFDIGSVITKRTRN 448  Golovinomyces magnicellulatus
KKF96681   439 SHHPLSSAFSgvtfaanilnrivppssdersgdkvrhqekNPNNSNDGDVEAEDARRAR 497  Ceratocystis platani
TDZ61739   745 LGYPLAQFYAgn--------------------------glRDRVFGPPEPGSEAPETPS 777  Colletotrichum trifolii
SZF00776   389 YSQWNALDQFrgd-------------------------dlSRLIRGQEAMTPAASKKRG 422  Blumeria graminis f. sp. hordei
ODA83247   401 HAHPLAEEFAgvglqv-------------------rlqglKTDGLGLDETEVEEVGRRR 440  Drechmeria coniospora
CDR39169   464 QIPGLAEFWKetvvgqmapfeggkaadekkrraaglspaqRKARKTEDAPEIEQSREVK 522  Rhodotorula toruloides
VBB72948   381 IPHPLAPFFAgeglaqqlgfispds-dvsgdvpatprsrrRTASQALELEEDEVARRVR 438  Podospora comata

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