5LEF,5LEF


Conserved Protein Domain Family
RBD_KIF20A
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cd21787: RBD_KIF20A 
RAB6 binding domain (RBD) found in kinesin-like protein KIF20A, and similar proteins
KIF20A, also called GG10_2, or mitotic kinesin-like protein 2 (MKlp2), or Rab6-interacting kinesin-like protein, or rabkinesin-6, is a mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, it is involved in recruitment of PLK1 (polo-like kinase 1) to the central spindle. KIF20A interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. It may act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. KIF20A has a microtubule plus end-directed motility. This model corresponds to RAB6 binding domain (RBD) of KIF20A. KIF20A-RBD is a dimer composed of two parallel alpha helices that form a right-handed coiled-coil additionally stabilized by an inter-helical cysteine bridge.
Links
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Statistics
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PSSM-Id: 409645
Aligned: 32 rows
Threshold Bit Score: 54.9128
Created: 21-Apr-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
RAB6 bindinghomodimer
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:RAB6 binding site [polypeptide binding site]
Evidence:
  • Comment: KIF20A-RAB6-binding domain (KIF20A-RBD) is a dimer composed of parallel helices that form a right-handed coiled-coil stabilized by an inter-helical cysteine bridge and two RAB6 molecules bind on opposite sides of the dimer
  • Structure:5LEF: Mus musculus RAB6 binding domain (RBD) of kinesin family protein KIF20A forms a dimer with each monomer binding one RAB6; contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                              # ## ### ## ### #                  
5LEF_C          2 AMEQWCSERLDNQKELMEELYEEKLKILKESLTTFYQEQIQERDEKIEELETLLQE 57   house mouse
NP_001012801  608 QKEQWWSQHIDAQKELLEELYEDKLNNLKESLTDYYQEEIQERDEKIEELQAALQE 663  chicken
XP_016847045  461 EKERWWSDYMEAEKDTLEKMHESNLNSQKELLTDYYLEQIEDRDERIKELEAALQE 516  green anole
XP_007889550  611 SMEKHWREQLVEQKEQLEDFYEAKMKNFQEYVKLYYQSSAADEDENYSDSDHDSDG 666  elephant shark
O95235        602 QREQWCSEHLDTQKELLEEMYEEKLNILKESLTSFYQEEIQERDEKIEELEALLQE 657  human
XP_028908452  617 ERERWYSEHLDTQKELLEDLYEDKLKNLKESLTTYYREELRERDEQMEELEAALQE 672  platypus
KFO81442      600 QKEQMYRECLDTQRDQLEELYEGKLDILKEALTDYYKEKIQERDEKIEELQAALQE 655  common cuckoo
XP_028574374  748 KKEQWTSEHVDIQKEMLEDVYEEKLNSLKESLTDYYQEKIESQDEKIKELQDALQE 803  Common wall lizard
GCF59194     1034 QREQSSRDQVDAQKEILEKMYEEKLTHLKELLTDYYQEEIEDRDEKIKELESALEE 1089 Paroedura picta
XP_015268018  596 QREQSISEQVDAQKEILEEMYDFKLNHLKEMLADYYQEKIENQDEKIQELEASLQE 651  Gekko japonicus

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