Conserved Protein Domain Family
CTD_KDM2B

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cd21785: CTD_KDM2B 
C-terminal domain found in Lysine-specific demethylase 2B
Lysine-specific demethylase 2B (KDM2B) is also called Ndy1, CXXC-type zinc finger protein 2, F-box and leucine-rich (LRR) repeat protein 10 (FBXL10), F-box protein FBL10, JmjC domain-containing histone demethylation protein 1B (Jhdm1b), Jumonji domain-containing EMSY-interactor methyltransferase motif protein (protein JEMMA), or [Histone-H3]-lysine-36 demethylase 1B. It is a ubiquitously expressed histone H3 lysine 4 (H3K4me2) or histone H3 lysine 36 (H3K36me2) demethylase that functions as a regulator of chemokine expression, cellular morphology, and the metabolome of fibroblasts. It regulates the differentiation of Mesenchymal Stem Cells (MSCs) and has been implicated in cell cycle regulation by de-repressing cyclin-dependent kinase inhibitor 2B (CDKN2B or p15INK4B). It also plays a role in recruiting polycomb repressive complex 1 (PRC1) to CpG islands (CGIs) of developmental genes and regulates lysine 119 monoubiquitylation on H2A (H2AK119ub1) in embryonic stem cells (ESCs). KDM2B also acts as an oncogene that plays a critical role in leukemia development and maintenance. It consists of two Jumonji domains (JmjN and JmjC), a CXXC zinc-finger domain, a plant homeodomain (PHD) finger, an F-box domain, followed by an antagonist of mitotic exit network protein 1 (AMN1) domain. This model corresponds to a small conserved region in KDM2B between the JmjC domain and the CXXC zinc-finger domain, which has been called the C-terminal domain by literature.
Statistics
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PSSM-Id: 412026
Aligned: 10 rows
Threshold Bit Score: 109.186
Created: 19-Mar-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8NHM5        507 THLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHADDDPs-LAITGVPVVTWP 573  human
XP_004945618  280 THLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEDMKNILKEHADDDQn-LAISGVPVVSWP 346  chicken
Q640I9        468 THLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEDMKTVLKEHADDDNn-LAISGVPVVMWP 534  African clawed frog
XP_005989042  470 THLTEFELKGLKALVEKLESLPENKKCIPEGIEDPNALLEDMKTVLKEHVDDDQn-LAISGVPVVSWP 536  coelacanth
XP_021328058  233 SHLTEFELNGLKALVEKLESLPENKKCVPEGIEDPQALLDDVKVVLKEHADDNPk-LAISGSPIVCWP 299  zebrafish
NP_001365792  474 THLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHVDDDPt-LAITGVPVVSWP 540 
NP_001003953  480 THLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHVDDDPt-LAITGVPVVSWP 546  house mouse
Q6P1G2        480 THLTEFELKGLKALVEKLESLPENKKCVPEGIEDPQALLEGVKNVLKEHVDDDPt-LAITGVPVVSWP 546  house mouse
XP_018099685   87 THLTEFELKGLKALVEKLESLPENKKCVPKGIEDPQALLEEMKTVLKEHADDDNn-LAISGVPVVTWA 153  African clawed frog
XP_007900539  306 IHLTEFELKGLKALVEKLESLPDNKKCVPEGIRDASALLGDMKVRAGPRWCWWGgsNLFQEEEEWEWE 373  elephant shark
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