Conserved Protein Domain Family

cd21764: CEN_USH1G_ANKS4B 
central domain found in usher syndrome type-1G protein, ankyrin repeat and SAM domain-containing protein 4B, and similar proteins
The family includes usher syndrome type-1G protein (USH1G), ankyrin repeat and SAM domain-containing protein 4B (ANKS4B), and similar proteins. USH1G, also called scaffold protein containing ankyrin repeats and SAM domain (Sans), is an anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A, that mediates mechanotransduction in cochlear hair cells. It is required for normal development and maintenance of cochlear hair cell bundles, as well as for normal hearing. ANKS4B, also called Harmonin-interacting ankyrin repeat-containing protein (Harp), is highly expressed in intestine and is essential for intermicrovillar adhesion. As part of the intermicrovillar adhesion complex (IMAC), ANKS4B plays a role in epithelial brush border differentiation, controlling microvilli organization and length. It may be involved in cellular response to endoplasmic reticulum stress. Both USH1G and ANKS4B contain four N-terminal ANK repeats, a central region, and a sterile alpha motif (SAM) followed by a C-terminal type I PDZ binding motif (PBM). This model corresponds to the central region (CEN), which contains the conserved regions CEN1 and CEN2. CEN is directly responsible for USH1G binding to the MYO7A MyTH4-FERM tandem, as well as for ANKS4B binding to the N-terminal MyTH4-FERM-SH3 supramodule of MYO7B.
PSSM-Id: 409640
Aligned: 5 rows
Threshold Bit Score: 46.6906
Created: 17-Aug-2020
Updated: 25-Oct-2021
Aligned Rows:
myosin tail
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:myosin tail binding site [polypeptide binding site]
  • Comment:CEN domains bind to myosin tail homology 4-protein 4.1, ezrin, radixin, moesin (MyTH4-FERM) domains in the myosin tail
  • Structure:5F3Y; Mus musculus ANKS4B in complex with MYO7B, contacts at 4A
    View structure with Cn3D
  • Structure:3PVL; Homo sapiens USH1G in complex with Myosin VIIa MyTH4-FERM-SH3, contacts at 4A
    View structure with Cn3D

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Feature 1                 ##  ## ######                                                          
5F3Y_B         4 EEDDDVQHESILNRPGLGSIVFSRNRvldfedisdskrelgfkmpselfqrqgaagtveeeeeeeeeeeeekreangtaG 83  house mouse
3PVL_B         2 EVSTDSGHDSLFTRPGLGTMVFRRNYlssglhglgredggldgvgaprgr-----lqsspsldddslgsanslqdrscgE 76  human
XP_018091944 249 EENEGKEKESIFNRPGLGNIMFRRNLasgistdfddlstarsdigfq-----------lpselftdeaengeesdneqeS 317 African clawed ...
XP_424609    246 DLLNDDGQHSIFTRPGLGKIVFGRNLaadidpgtvssqkegisfkms------------selfqnesaesstegdagssA 313 chicken
XP_018424536 250 GMAMEEGKQSIFNRPGLGNMVFKRNLamgintdfggnftaedertlk-----------vknalfaaddkneieddgeniN 318 Nanorana parkeri
Feature 1                      
5F3Y_B        84 DLPWDEEEVEWEED 97  house mouse
3PVL_B        77 ELPWDELDLGLDED 90  human
XP_018091944 318 IVTWNEDEMELDDE 331 African clawed frog
XP_424609    314 EVPWQEEELLWDDE 327 chicken
XP_018424536 319 IAWNDDDEMEIDEE 332 Nanorana parkeri

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