5WAI,5WAK,6C23,6NQ3


Conserved Protein Domain Family
ZnB-Zn_SUZ12

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cd21750: ZnB-Zn_SUZ12 
Click on image for an interactive view with Cn3D
zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn) domain found in suppressor of zeste 12 protein (SUZ12) and similar proteins
Suppressor of zeste 12 protein (SUZ12), also called chromatin precipitated E2F target 9 protein (ChET 9 protein), or joined to JAZF1 protein, is a Polycomb group (PcG) protein that acts as a component of the Polycomb Repressive Complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. This model corresponds to a unique structural ZnB-Zn platform consisting of zinc finger-binding (ZnB) and C2H2-type zinc finger (Zn), which forms an intramolecular complex that governs the mutual exclusive binding of Jarid2 and EPOP in PRC2 holo complexes.
Statistics
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PSSM-Id: 439246
Aligned: 34 rows
Threshold Bit Score: 110.478
Created: 2-Mar-2020
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding sitetetramer
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:C C H HClick to see conserved feature residue pattern help
Evidence:
  • Structure:5WAI; Homo sapiens SUZ12 binds Zn2+ ion

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                         
5WAI_B          7 DHELFLQAFEKPTQIYRFLRTRNLIapiflhrtltymshrnsrtnikrktfkvddmlskvekmkgeqeshslsahlqltf 86   human
NP_652059      54 EQELFLQAFEKPTQIYRYLRNRHETnpiflnrtlsymkermsrnnkkrisfqvnsmlesitqkseavsqnylhviydslh 133 
Q9NJG9         54 EQELFLQAFEKPTQIYRYLRNRHETnpiflnrtlsymkermsrnnkkrisfqvnsmlesitqkseavsqnylhviydslh 133  fruit fly
XP_012556196   26 DYELFLHTYEKPTWIYRFIQRRHQLspfmlhrnlsyfkdrrtkrpqlqqvkrknfqldlllkdfkstelnvksesneenh 105  Hydra vulgaris
XP_012559187   79 EQELFKDDFVKVEIHLCQVYHKKKKcqdseqmdliplgsckapwnprtqlllpcssvnltvppnafvengravkahilsf 158 
XP_012793898  205 KQEAFVRAFAIPTHLYRYLSHRHRDrplyldrtlsylmpnpsrkqssgsrrsinriverlierrkdcrqndeskdsskys 284 
CRL05406     2883 NRDPFFQTFEKPTQIYRYLKTRFVAsplflhrnlsymkgrstrnhkrracfkitdmmknkneenekdananenliiafvr 2962 Clunio marinus
XP_019853747   19 DHELFLEAYEKPTQIYRFLRSRHLLepiflqrnlsymkrsrtkpkrrnmlklndlakqtkevkkdiaeeiksdnqlkitf 98   Amphimedon qu...
XP_019853748   24 LNDLAKQTKEVKKDIAEEIKSDNQLkitfqaldcstssstiegehkpmsfdkrpmgvevmlykfkqpspeillttpcslp 103 
XP_031629898   10 DCELFLRAFEKPTQIYRYLRTRRLLsplflqrnlvylkdritkqrkcprrqrkdfdwptflkelkpvktndpsdsslvfk 89   swede midge
Feature 1                                                                                         
5WAI_B         87 tgffhkndkpspnseneqnsvtlevllvkvchkkrkdvscpirqvptgkkqvplnpdlnqtkpgnfpslavssnefepsn 166  human
NP_652059     134 eklparldnesgedllqeqllceagesvsvettlykitrskrkdstldfqellskcsqivynpkdrvgehatisiplqtm 213 
Q9NJG9        134 eklparldnesgedllqeqllceagesvsvettlykitrskrkdstldfqellskcsqivynpkdrvgehatisiplqtm 213  fruit fly
XP_012556196  106 ylnisfngffhgpgfaeeifetnepkeqelfkddfvkveihlcqvyhkkkkcqdseqmdliplgsckapwnprtqlllpc 185  Hydra vulgaris
XP_012559187  159 tviitvpkkgsskniksdrteenglhrplkrqkcdnsdadsetnsltypadvcvas------------------------ 214 
XP_012793898  285 esisssssttpgellqelelvfegfydsekevdwvtvdasvnvhlrfgwawrrkicpddtilnitpnpirincyshstgy 364 
CRL05406     2963 fkdevlnaknvkvetklekvshkrrkegtsgqnliniglskvdvnvdnngsellpaicvtndqferenpqtsyqltfdie 3042 Clunio marinus
XP_019853747   99 qaldcstssstiegehkpmsfdkrpmgvevmlykfkqpspeillttpcslpcdcislgkcvipgtgtrassaasssnrns 178  Amphimedon qu...
XP_019853748  104 cdcislgkcvipgtgtrassaasssnrnsitvpgsvlswreidhgpvgthvlafrivpltnddnlvssldkkksrkrpln 183 
XP_031629898   90 flgyfdenilstendtatvniyvlcrskhqpkfllktipveinpriiinpvpitlskeelmrnvsrtdrscelvievsyv 169  swede midge
Feature 1                                                                                         
5WAI_B        167 shmvksysllfrvtrpgrrefngmi------------------------------------------------------- 191  human
NP_652059     214 rpmgeqhtlykllfrikvls------------------------------------------------------------ 233 
Q9NJG9        214 rpmgeqhtlykllfrikvls------------------------------------------------------------ 233  fruit fly
XP_012556196  186 ssvnltvppnafvengravkahilsftvi--------------------------------------------------- 214  Hydra vulgaris
XP_012559187      --------------------------------------------------------------------------------     
XP_012793898  365 tslvnspptsnndniitatsntthtacrfsltdlinqvkwntssgrltsaqlelhvsaterrwlkrpdlshgavslngit 444 
CRL05406     3043 aitafvpkdsgdeq------------------------------------------------------------------ 3056 Clunio marinus
XP_019853747  179 itvpgsvlswreidhgpvgthvlafrivpltnddnlvssldkkksrkrplntglssgidshdsvtpsingcihieeneqq 258  Amphimedon qu...
XP_019853748  184 tglssgidshdsvtpsingcihieeneqqsvpreeikdkilnkkvpggttlpsltattrdsnlvisisrnpneatdsspt 263 
XP_031629898  170 ehqnngehldksqrskkrkk------------------------------------------------------------ 189  swede midge
Feature 1                                                                                         
5WAI_B            --------------------------------------------------------------------------------      human
NP_652059         --------------------------------------------------------------------------------     
Q9NJG9            --------------------------------------------------------------------------------      fruit fly
XP_012556196      --------------------------------------------------------------------------------      Hydra vulgaris
XP_012559187      --------------------------------------------------------------------------------     
XP_012793898  445 pnisnnltnhivnhinhnnnsnnnlsqnlsksvhtdgknnnsrvtfingnplrkgglssnsypvqyataplplivssigf 524 
CRL05406          --------------------------------------------------------------------------------      Clunio marinus
XP_019853747  259 svpreeikdkilnkkvpggttlpsltattrdsn--lvisisrnpneatdssptappktngsscrirrnelqllvdnstns 336  Amphimedon qu...
XP_019853748  264 appktngs-----------------------------------------------------scrirrnelqllvdnstns 290 
XP_031629898      --------------------------------------------------------------------------------      swede midge
Feature 1                                                                                         
5WAI_B        192 --------------------------------------------ngetnenidvneelparrkrnredgektfvaqmtvf 227  human
NP_652059     234 ------------------------------------------------pstcndenaetppnkrsrpnekmfgselilye 265 
Q9NJG9        234 ------------------------------------------------pstcndenaetppnkrsrpnekmfgselilye 265  fruit fly
XP_012556196  215 ----------------------------------------itvpkkgsskniksdrteenglhrplkrqkcdnsdadset 254  Hydra vulgaris
XP_012559187      --------------------------------------------------------------------------------     
XP_012793898  525 dststgrqllltpglyelrlgvdtsdgngssggvmnkvvplkclddnvseksyvsanndqasdtcssqvewrrirfpnss 604 
CRL05406     3057 ------------------------------------------------------psklpcvskqyhaelpvydkcgrnll 3082 Clunio marinus
XP_019853747  337 ltsssclpsslqpvenetcsrkrphsetspsplnpskkhctsssidndipspagdlpplsssssilkeeeedkyyaelva 416  Amphimedon qu...
XP_019853748  291 ltsssclpsslqpvenetcsrkrphsetspsplnpskkhctsssidndipspagdlpplsssssilkeeeedkyyaelva 370 
XP_031629898  190 ------------------------------------------------ishdarlpvfdkkghcdllegeyelnldvsre 221  swede midge
Feature 1                                                                                         
5WAI_B        228 dknrrlqlldgeyevamqemeecpiskkratwetildgkrlppfetfsqgptlqftlrwtgetndkstapiakplatrns 307  human
NP_652059     266 kssgfitegeyeamlqplnstsiksfspkkctwetmpdsyiplsltydvyqqspmlkfhltlsneqlpemisapelqryv 345 
Q9NJG9        266 kssgfitegeyeamlqplnstsiksfspkkctwetmpdsyiplsltydvyqqspmlkfhltlsneqlpemisapelqryv 345  fruit fly
XP_012556196  255 nsltypadvcvasfsaemilydrlknclltdgdyelllhensptirksnsweskfksklgpfaafsfgptikfnltwgtk 334  Hydra vulgaris
XP_012559187  215 -------------fsaemilydrlknclltdgdyelllhensptirksnsweskfksklgpfaafsfgptikfnltwgtk 281 
XP_012793898  605 taldeysrwprlrfsviwhnklennqiispcrsmetrrqdnthvhmegrssltrsmtsshnrdviksqnqsatphkqivl 684 
CRL05406     3083 lsgvyhvtaletnffrpsrmpcwesfsndsdqhimnwaeevnkhffaekdtnpfktfestpqielyikrsrskpledfie 3162 Clunio marinus
XP_019853747  417 fdsrkecllydgeyqlhltkltpkrklptelrvngmkpstlfkwgsgiepanksytesvketvslklsiewnrgppvpri 496  Amphimedon qu...
XP_019853748  371 fdsrkecllydgeyqlhltkltpkrklptelrvngmkpstlfkwgsgiepanksytesvketvslklsiewnrgppvpri 450 
XP_031629898  222 ttpirkvdrltwatdipkmltgdkryfqnrslkfmllwnsedgtkskstspihnenamlnttntdwcgiqtgsttslsts 301  swede midge
Feature 1                                                                               #  #      
5WAI_B        308 eslhqenkpgsvkptqtiavkeslttdlqtrkekdtpnenrqkLRIFYQFLYNN---NTRQQTEARDDLHCPWCTLNCRK 384  human
NP_652059     346 qhldavaemnynnnnynnnnncsglkngsgggnstvckttpehIQIVYNFMYSN---NTRQQTEYTQELNCPWCGLDCLR 422 
Q9NJG9        346 qhldavaemnynnnnynnnnncsglkngsgggnstvckttpehIQIVYNFMYSN---NTRQQTEYTQELNCPWCGLDCLR 422  fruit fly
XP_012556196  335 piaplaaaykclaspyqdnsnikielemsketksvavtsaeknMRMFYRFIYNG---STRQQTEAKEGMACPWCALDCKR 411  Hydra vulgaris
XP_012559187  282 piaplaaaykclaspyqdnsnikielemsketksvavtsaeknMRMFYRFIYNG---STRQQTEAKEGMACPWCALDCKR 358 
XP_012793898  685 kescdssvfkdstgldkclsnrvqqslsahfgpdvdkptstktPHLIHPITYGFvfgGNLQQWSQSTDLVCPWCHLDCAR 764 
CRL05406     3163 rptflsdhhnnnsdkenttnnnsitsngvnghhnnsttlepssKPFIFQFVVNS---STKQRTEERMDFVCPWCSLNCMR 3239 Clunio marinus
XP_019853747  497 eeisntaldfaklrenydeliqsiskrtqsaavqqqksadrktTPTAFNFLYNK---NTLQQTELKTDCVCPWCSLNCGE 573  Amphimedon qu...
XP_019853748  451 eeisntaldfaklrenydeliqsiskrtqsaavqqqksadrktTPTAFNFLYNK---NTLQQTELKTDCVCPWCSLNCGE 527 
XP_031629898  302 sgilsdmssddaeittlttkklpnslpitlanrspyvellgmgSHLIYRFIYND---DLSQKTVAWDEFLCPWCYLNCTS 378  swede midge
Feature 1                    #    #                           
5WAI_B        385 -----LYSLLKHLKLCHSRFIFNYVYHP--KGARIDVSINECYD 421  human
NP_652059     423 -----LYALLKHLKLCHARFNFTYQPAG--SGARIDVTINDAYD 459 
Q9NJG9        423 -----LYALLKHLKLCHARFNFTYQPAG--SGARIDVTINDAYD 459  fruit fly
XP_012556196  412 -----LYVLLKHFKTCHPRFSFVYTAIK--KGHLIDVRIKENFE 448  Hydra vulgaris
XP_012559187  359 -----LYVLLKHFKTCHPRFSFVYTRSQkvTNRAVQFHRPERCD 397 
XP_012793898  765 agdkgPEALILHLRTCHPRFRLKVMWDPshTQLRLQVSLNEAYD 808 
CRL05406     3240 -----IYSLLKHLKLSHARLLFQYIDEG--SKGRIDVYVNDMYD 3276 Clunio marinus
XP_019853747  574 -----LYSLLKHMSLCHPRFLFTYTPIE--GGASIDVRINKMYD 610  Amphimedon queenslandica
XP_019853748  528 -----LYSLLKHMSLCHPRFLFTYTPIE--GGASIDVRINKMYD 564 
XP_031629898  379 -----LHPLLMHLRLCHDRFKFSYTQKE--DGIQVDVSINERYN 415  swede midge

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