5XQZ,5B5W,5NCM


Conserved Protein Domain Family
MobB_NDR_LATS-like
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cd21742: MobB_NDR_LATS-like 
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Mob-binding domain found in the NDR/LATS family serine/threonine protein kinases
The nuclear Dbf2-related (NDR)/large tumor suppressor (LATS) family includes NDR, LATS, CBK1, and Sid2p. They are involved in regulating many cellular functions including contraction, motility, division, proliferation, apoptosis, morphogenesis, and cytokinesis. NDR/LATS kinases bind to highly conserved Mob (Mps One binder) coactivators, forming regulatory complexes that control a diverse set of in vivo effector proteins, and are essential and evolutionarily conserved components of "Hippo" signaling pathways. Mob association creates a novel binding pocket that participates in the formation of the active state of NDR/LATS kinases. These kinases contain a regulatory domain located N-terminal to the serine/threonine kinase domain (called the N-terminal regulatory (NTR) domain) and an insert within the catalytic domain that contains an auto-inhibitory sequence. This model corresponds to the NTR or Mob-binding domain of NDR/LATS family serine/threonine protein kinases.
Links
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Statistics
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PSSM-Id: 439267
Aligned: 37 rows
Threshold Bit Score: 51.4331
Created: 13-Oct-2021
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Mob binding
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:Mob binding site [polypeptide binding site]
Evidence:
  • Structure:5B5W; Homo sapiens LATS1 in complex with Mob kinase activator 1B; contacts at 4A
  • Structure:5NCM; Saccharomyces cerevisiae CBK1 in complex with kinase activator Mob2; contacts at 4A
  • Structure:5XQZ; Homo sapiens NDR2 in complex with Mob kinase activator 1A; contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        ## ### ##  ##  #  #   #                         #  ### ##  ##  
5XQZ_C         5 MKLTLENFYSNLILQHEERETRQKKLEVAMEEeg-laDEEKKLRRSQHARKETEFLRLKRTRL 66  human
5B5W_U        20 FKFFMEQHVENVLKSHQQRLHRKKQLENEMMRvg-lsQDAQDQMRKMLCQKESNYIRLKRAKM 81  human
XP_002904127  13 TKAYLEQKYATMKREREESRERRNTLEQQMAAlr-ltERKKEQYRQELRSKELQSLRHQRKRL 74  Phytophthora infestans T30-4
ETO21969      32 MKQKVASTVQNRIRFQEEREKRLMQVNKKLQQst-ldVDKKTQYLETFLKNERNVLRKERHKV 93  Reticulomyxa filosa
ETO23961      58 MKQRVENTVRKRVSFQRERETRLSQINKKLQDsg-leEGQKQKYLKEFMENERSALREERHKV 119 Reticulomyxa filosa
RDD46730     333 TKKYLETMYRKTLMYKDEREKRQQKLEEELEKst-laEKDKSQFRKALLQHETNLLRGKRSKV 394 Trichoplax sp. H2
P0C1B1       299 VKVFLETHFHTLLSGLDARTQRRLELDQYIETfp-lsPEEVVRVRKHWVTQERDYLRQYRVLK 360 Aspergillus nidulans FGSC A4
EKG17846     168 TKVYLETYYNSLRLPDPSPRQQRRCSIERQLAelpisREEKKDRLKQWCAHESEHLRHTRLLK 230 Macrophomina phaseolina MS6
KNE58960     121 TKIYFEAYFDRLMSTTTTGRNKRRLQLEADLEalnvsEDEKRTIRRQWLQKETEYIRSLRSRV 183 Allomyces macrogynus ATCC 38327
OAQ31695     128 TKIFFESYYHRLLTNPSGRSRRRLQLERQLETlg-isEDDKAEMRQEWMANETEYMRLLREKI 189 Mortierella elongata AG-77

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