Conserved Protein Domain Family
CTNNAbd_dArm
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cd21726: CTNNAbd_dArm 
alpha-catenin binding domain found in Drosophila melanogaster armadillo segment polarity protein (dArm) and similar proteins
dArm is a Drosophila catenin that plays a role during central nervous system development. It can associate with alpha-catenin. The neural isoform of dArm may associate with CadN and participate in the transmission of developmental information. Its cytoplasmic isoform accumulates through Wingless (Wg) signaling; arm function in Wg signal transduction is required early in development for determination of neuroblast fate. Arm and Abl proteins function cooperatively at adherens junctions in both the CNS and epidermis. This model corresponds to a small region at the C-terminus of dArm, which shows high sequence similarity with alpha-catenin binding domain of catenin beta-1 (CTNNB1).
Links
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Statistics
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PSSM-Id: 439243
Aligned: 10 rows
Threshold Bit Score: 162.584
Created: 18-Mar-2020
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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putative CNTTA
Feature 1:putative CNTTA binding site [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Mus musculus CTNNB1 interacts with CNTTA2
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              ####   ## ###  ##  #                 ### ##  ##  #  #########        
P18824        85 DQVDDMNQQLSQTRSQRVRAAMFPETLEEGIEIPSTQFDPqQPTAVQRLSEPSQMLKHAVVNLINYQDDAELATR 159 fruit fly
P35223        93 EQVDEMNQQLTQTRSQRVRAAMFPETLEEGVQIPSTQFDPaHPTAVQRLSEPSQMLKHAVVNLINYQDDADLATR 167 Hawaiian sea urchin
NP_001158477 154 EQVDEMNQQLNQTRSQRVRAAMFPETLDEGVQIPSTQFDPqHPTAVQRLAEPSQMLKHAVVNLINYQDDAELATR 228 Saccoglossus kowalev...
XP_027226963  85 EQVDDMNQQLNQTRSQRVRAAMFPETLDEGMEIPSTQFDPqQPTAVQRLAEPSQMLKHAVVNLINYQDDADLATR 159 Penaeus vannamei
XP_013382710  96 EQVDEMNQQLNQTRSQRVRAAMFPETLEEGMQIPSTQIHPsEPTAVQRLAEPSQMLKHAVVNLINYQDDADLATR 170 Lingula anatina
P35224       100 EQVDEMNQQLNQTRSQRVRAAMFPETLEEGVQIPSTQLDPgQPTAVQRLSEPSQMLKHAVVNLINYQDDADLATR 174 Urechis caupo
PVD37950      97 EQVEDINQQLNQTRSQRVRAAMFPETLPEGVQIPSTQVHPdQPTAVQRLAEPSQMLKHAVVNLINYQDDADLATR 171 Pomacea canaliculata
NP_001310743  90 EQVDEMNQQLNQTRSQRVRAAMFPETLEEGLEIPSTQFDPtQPTAVQRLAEPSQMLKHAVVNLINYQDDADLATR 164 common house spider
EFX85133      95 DQVEDMNAQLNQTRSQRIRAAMFPETLDEGMEIPSTQFDTtQPTAVQRLAEPSQMLKHAVVNLINYQDDADLATR 169 common water flea
AAY34439     103 EQVDEMNQQLIQTRSQRVRAAMFPETLDEGTQIPSTQFDPnQPTAVQRLAEPSQMLKHAVVNLINYQDDADLATR 177 Florida lancelet

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