Conserved Protein Domain Family
alphaCoV_Nsp13-helicase

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cd21723: alphaCoV_Nsp13-helicase 
helicase domain of alphacoronavirus non-structural protein 13
This model represents the helicase domain of non-structural protein 13 (Nsp13) from alphacoronavirus, including Porcine epidemic diarrhea virus and Human coronavirus (CoV) NL63. Helicases catalyze NTP-dependent unwinding of nucleic acid duplexes into single strands and are classified based on the arrangement of conserved motifs into six superfamilies. CoV Nsp13 is a member of the helicase superfamily 1 (SF1); SF1 and SF2 helicases do not form toroidal structures, while SF3-6 helicases do. Nsp13 is a component of the viral RNA synthesis replication and transcription complex (RTC). It is a multidomain protein containing a Cys/His rich zinc-binding domain (CH/ZBD), a stalk domain, a 1B domain involved in nucleic acid substrate binding, and a SF1 helicase core.
Statistics
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PSSM-Id: 409656
Aligned: 48 rows
Threshold Bit Score: 613.28
Created: 6-May-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:based on similarity to other helicases of the SF1 family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                           ######                                        
P0C6Y4       5279 KLHPAFNIpeaYSSLVPYYQLiGKQKITTIQGPPGSGKSHCVIGLGLYYPGARIVFTACSHAAVDSLCVKASTAYSNDKC 5358 Porcine epide...
P0C6Y5       5179 KLYPVFNIaeaYNTLVPYYQMiGKQKFTTIQGPPGSGKSHCVIGLGLYYPQARIVYTACSHAAVDALCEKAAKNFNVDRC 5258 Porcine trans...
AEK25510     5193 KLYPTFNIaeaYTTLVPYYQMiGKQKFTTIQGPPGSGKSHCVIGLGLYYPQARIVYTACSHAAVDALCEKASKNFNVDKC 5272 Feline corona...
AVY53334     5171 KLYPTFNIaedYATLVPYYQMiGKQKFTTIQGPPGSGKSHCVIGLGLYYPGARIVYTACSHAAVDSLCEKAAKNFNIDKC 5250 Alphacoronavi...
BAV31348     1106 KLYPAFNVhedYATLVPYYQMiGKQKYTTIQGPPGSGKSHCVIGLGLYYPGARIVYTACSHAAVDSLCEKASKNFNIDKC 1185 Ferret corona...
ATP66737     5219 KLYPSFYIdpsYSSLVPHYQLiGRQKITTIQGPPGSGKSHTMVGLGLYYPSARILFTACSHAAVDSLCVKAAKTFAHEKC 5298 Rodent corona...
AKZ66481     5176 KLYPVFNIteaYNTLVPYYQMiGKQKFTTIQGPLGSGKSHCVMGLGLYYPQARIIYTACSHAAVDALCEKAAKNFNVDRC 5255 Alphacoronavi...
YP_009380520 1158 KLYPSFYIdpaYSALVPHYQLiGRQKITTIQGPPGSGKSHTMVGLGLYYPSARILFTACSHAAVDSLCVKAAKTFAHEKC 1237 Coronavirus A...
ASF90474     4831 RLFSTLNVkeeYVNLVPYYTMiGKQRVTTIQGPPGSGKSHCIIGLGLYYPTIKIVFTACSHAAVDSLCVKAFKNYNIVDC 4910 Wencheng Sm s...
ASF90464     4826 RLFSTLNVkeeYVNLVPYYTMiGKQRVTTIQGPPGSGKSHCIIGLGLFFPTIKIVFTACSHAAVDSLCNKAFKNYNIVDC 4905 Wencheng Sm s...
Feature 1                                                                                  #      
P0C6Y4       5359 SRIIPQRARVECYDGFKSNNtsAQYLFSTVNALPECNADIVVVDEVSMCTNYDLSVINQRIsYRHVVYVGDPQQLPAPRV 5438 Porcine epide...
P0C6Y5       5259 SRIIPQRIRVDCYTGFKPNNtnAQYLFCTVNALPEASCDIVVVDEVSMCTNYDLSVINSRLsYKHIVYVGDPQQLPAPRT 5338 Porcine trans...
AEK25510     5273 SRIIPQRIRVECYTGFKPNNtnAQYLFCTVNALPEANCDIVVVDEVSMCTNYDLSVINSRLsYKHIVYVGDPQQLPAPRT 5352 Feline corona...
AVY53334     5251 SRIIPMRARVECYSGFKPNNnnAQYIFSTVNALPECNCDIVVVDEVSMCTNYELSVINSRVsYKHIVYVGDPQQLPAPRT 5330 Alphacoronavi...
BAV31348     1186 SRVVPMRARVECYNGFKPNNnaAQYLFSTVNALPECSCDIVVVDEVSMCTNYELSVINSRVsYKHIVYVGDPQQLPAPRT 1265 Ferret corona...
ATP66737     5299 TRIVPAKARVECYSGFKVNNngAQYVFSTINALPEISVDLVVVDEVSMCTNYDLSVLNSRVaYRHIVYVGDPQQLPAPRT 5378 Rodent corona...
AKZ66481     5256 SRIIPQRIRVDCYTGFKPNNtnAQYLFCTVNALPEASCDIVVVDEVSMCTNYDLSVINSRLsYKHIVYVGDPQQLPAPRT 5335 Alphacoronavi...
YP_009380520 1238 TRIIPAKARVECYSGFKVNNnsAQYVFSTINALPEVSVDLVVVDEVSMCTNYDLSVLNSRVaYRHIVYVGDPQQLPAPRT 1317 Coronavirus A...
ASF90474     4911 SRIIPARARVECFDKFRINDcsAKYIFSTINALPDVVADVVVVDEVSMLTNYDLSIINSRVkYKHIVYVGDPQQLPSPRI 4990 Wencheng Sm s...
ASF90464     4906 SRIIPARARVECFDKFRVNDcsAKYVFSTINALPDVVADVVVVDEVSMLTNYDLSIINSRVkYKHIVYVGDPQQLPSPRI 4985 Wencheng Sm s...
Feature 1                                         #                                               
P0C6Y4       5439 MIsRGTLEPkDYNVVTQRMCALKPDVFLHKCYRCPAEIVRTVSEMVYENQFIPVHPDSKQCFKiFCKGNVQVDNGSSINR 5518 Porcine epide...
P0C6Y5       5339 LInKGVLQPqDYNVVTKRMCTLGPDVFLHKCYRCPAEIVKTVSALVYENKFVPVNPESKQCFKmFVKGQVQIESNSSINN 5418 Porcine trans...
AEK25510     5353 LInKGTLQPeDYNVVTQRMCKLGPDVFLHKCYRCPAEIVKTVSALVYENKFLPVNPESKQCFKmFVKGQVQIESNSSINN 5432 Feline corona...
AVY53334     5331 LInKGVLKPqDYNVITQRMCTLGPDVFLHKCFRCPAEIVNTVSALVYENKFKPVKPESKQCFKmYVRGNVQIDNGSSVNR 5410 Alphacoronavi...
BAV31348     1266 LInKGVLKPqDYNVITQRMCTLGPDVFLHKCYRCPAEIVNTVSALVYENKFKPVKGDSKQCFKmYVRGNVQIDNGSSVNR 1345 Ferret corona...
ATP66737     5379 LItKGALEPaDYNVVTRLMCTIGPDVFLNKCYRCPAEVVNSVSSLVYEDKFKPVNPPSNLCFKlLFKGAVHHDSGSCVNR 5458 Rodent corona...
AKZ66481     5336 LInKGVLQPqDYNVVTQRMCTLGPDVFLHKCYRCPAEIVKTVSALVYENKFVPVNPESKQCFKmFVKGQVQIESNSSINN 5415 Alphacoronavi...
YP_009380520 1318 LItKGALEPaDYNVVTRLMCTIGPDVFLSKCYRCPAEVVNSVSSLVYENKFKPVNAPSNLCFKlLFKGSVHHDAGSCVNR 1397 Coronavirus A...
ASF90474     4991 LItRGVLKPeDYNCVTRRMCLLGPDVFLNKCYRCPAEVVKTVSALVYENKFLAVNKISGKCFKvFLKGHVQVDNGSSVNR 5070 Wencheng Sm s...
ASF90464     4986 LItRGVLKPeDYNCVTRRMCLLGPDVFLNKCYRCPAEVVKTVSALVYENKFLAVNKISGKCFKvFLKGHVQVDNGSSVNR 5065 Wencheng Sm s...
Feature 1                                                        # #                          #   
P0C6Y4       5519 RQLDVVRMFLAKNPrWSKAVFISPYNSQNYVAsrlLGLQIQTVDSSQGSEYDYVIYAQTSDTAHASNVNRFNVAITRAKK 5598 Porcine epide...
P0C6Y5       5419 KQLEVVKAFLAHNPkWRKAVFISPYNSQNYVArrlLGLQTQTVDSAQGSEYDYVIYTQTSDTQHATNVNRFNVAITRAKV 5498 Porcine trans...
AEK25510     5433 KQLEVVKAFLAHNPkWRKAVFISPYNSQNYVArrlLGLQTQTVDSAQGSEYDYVIYTQTSDTQHAINVNRFNVAITRAKV 5512 Feline corona...
AVY53334     5411 KQLEVVKLFLAKNPkWKNATFISPYNSQNYVArrlLGLQTQTVDSAQGSEYDFVVYTQTSDTAHAVNINRFNVAITRAKI 5490 Alphacoronavi...
BAV31348     1346 KQLEVIKSFLAKNPkWKNATFISPYNSQNYVArrlLGLQTQTVDSAQGSEYDYVIYAQTSDTAHAVNINRFNVAITRAKV 1425 Ferret corona...
ATP66737     5459 KQLDIVKQFLARNPdWSKAVFISPYNSQNYVAarvLGLQTQTVDSAQGSEYDYVIYTQTSDTAHALNVNRFNVAITRAKK 5538 Rodent corona...
AKZ66481     5416 KQLEVVKAFLAHNPkWRKAVCISPHNSQNYVAsrlLGLETQTVDSAQGSEYDYVIYTQTSDTQHATNVNRFNVAITRAKV 5495 Alphacoronavi...
YP_009380520 1398 KQLDVVKQFLARNPdWSSAVFISPYNSQNYVAariLGLQTQTVDSAQGSEYDYVIYTQTSDTAHALNVNRFNVAITRAKK 1477 Coronavirus A...
ASF90474     5071 KQLDFVKTFLEHNKeWQKAVFISPYNSQNYVAskmLGLQTQTVDSAQGSEYDYVVYTQTSDTAHACNINRFNVAITRTKY 5150 Wencheng Sm s...
ASF90464     5066 KQLEFVKTFLEHNKeWQKAVFISPYNSQNYVAskmLGLQTQTVDSAQGSEYDYVIYTQTSDTAHACNINRFNVAITRTKY 5145 Wencheng Sm s...
Feature 1                             
P0C6Y4       5599 GILCIMCDrsLFDLLKFFEL 5618 Porcine epidemic diarrhea virus CV777
P0C6Y5       5499 GILCIMCDrtMYENLDFYEL 5518 Porcine transmissible gastroenteritis coronavirus strain Purdue
AEK25510     5513 GILCVMCDrkMYDNLDFYEL 5532 Feline coronavirus UU47
AVY53334     5491 GILCVMCDkaMYDGLNFYEI 5510 Alphacoronavirus Mink/China/1/2016
BAV31348     1426 GLLCVMCDkpMYDNLNFYEI 1445 Ferret coronavirus
ATP66737     5539 GIFCVMNDanLFNALEFQEI 5558 Rodent coronavirus
AKZ66481     5496 GILCIMCDrtMYDNLDFYEF 5515 Alphacoronavirus 1
YP_009380520 1478 GIFCVMNDvnLFNALEFKEI 1497 Coronavirus AcCoV-JC34
ASF90474     5151 GILCVMNNkkMYDDLDFGVI 5170 Wencheng Sm shrew coronavirus
ASF90464     5146 GILCIMNNkkMYDELDFGVI 5165 Wencheng Sm shrew coronavirus

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