Conserved Protein Domain Family
deltaCoV_Nsp13-helicase

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cd21721: deltaCoV_Nsp13-helicase 
helicase domain of deltacoronavirus non-structural protein 13
This model represents the helicase domain of non-structural protein 13 (Nsp13) from deltacoronavirus, including Bulbul coronavirus (CoV) HKU11 and Common moorhen CoV HKU21. Helicases catalyze NTP-dependent unwinding of nucleic acid duplexes into single strands and are classified based on the arrangement of conserved motifs into six superfamilies. CoV Nsp13 is a member of the helicase superfamily 1 (SF1); SF1 and SF2 helicases do not form toroidal structures, while SF3-6 helicases do. Nsp13 is a component of the viral RNA synthesis replication and transcription complex (RTC). It is a multidomain protein containing a Cys/His rich zinc-binding domain (CH/ZBD), a stalk domain, a 1B domain involved in nucleic acid substrate binding, and a SF1 helicase core.
Statistics
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PSSM-Id: 409654
Aligned: 10 rows
Threshold Bit Score: 682.806
Created: 6-May-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:based on similarity to other helicases of the SF1 family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                           ######                                        
ACJ12043     4753 SLIPDTvnasFYVQHFKSYNEIalQKVTTVLGPPGTGKSTFAIGLAKYYPNARICYTASSHAAIDALCEKAFKTLPVGQC 4832 Bulbul corona...
YP_002308496 4777 SLIPDTvgasFYVQHFKSYNEIalQKVTTVLGPPGTGKSTFAIGLAKYYPNARICYTASSHAAIDALCEKAFKTLPVGQC 4856 Thrush corona...
YP_005352837 4786 SLIADSvgasFYVQHFKSYNEIamQKVTTVLGPPGTGKSTFAIGLAKYYPNARICYTASSHAAIDALCEKAFKTLPVGQC 4865 White-eye cor...
YP_002308505 4839 SLLPDTvgasFYVQHFKSYNEIamQRVTTVLGPPGTGKSTFAIGLAKYYPNARICYTASSHAAIDALCEKAFKTLPVGQC 4918 Munia coronav...
YP_005352880 4701 TLIPDSvnasFYVQHFKSYNDIamQKVTTVLGPPGTGKSTFAIGLAKYFPNARICYTASSHAAIDALCEKAFKTLPVEHC 4780 Common moorhe...
BBC54821     4716 SLLPDTvgasFYVQHFKSYNDIamQKVTTVLGPPGTGKSTFAIGLAKYYPNARICYTASSHAAIDALCEKAIKTLPVGQC 4795 Falcon corona...
AWV67106     4790 ALLPDSvgasYYVQHFKSYNEIamQRVTTVLGPPGTGKSTFAIGLAKYYPSARICYTASSHAAIDALCEKAFKTLPVGQC 4869 Sparrow delta...
YP_005352870 4723 NLRPDTvsasAYLNHYKSYNEIalRKVTTVLGPPGTGKSTFAIGLACYYPGARVCYTASSHAAIDALCQKALHALPVENC 4802 Wigeon corona...
YP_005352862 4786 YASPSEa--aFYATHFKSYDSIakQKITTVLGPPGTGKSTFAIGLAKYFPNARICYTASSHAAIDALCEKAYKTLPREQC 4863 Night heron c...
AWR88314       12 NYVKDTlncnHLLNHFESYNNIikRRITTVLGPPGTGKSTFAIGLAMYYPSARVCYTASSHAAIDALCDKAVKALPSDEC 91   Deltacoronavi...
Feature 1                                                                                  #      
ACJ12043     4833 SRIVPTRTTVECFQDFVVNNTtaQYIFSTINALPDIKCDIVVVDEVSMLTNYELSSVNARLVYnHIVYVGDPYQLPSPRT 4912 Bulbul corona...
YP_002308496 4857 SRIVPTRTTVECFQGFVVNNTtaQYIFSTINALPDIKCDIVVVDEVSMLTNYELSSVNARLVYnYIVYVGDPYQLPSPRT 4936 Thrush corona...
YP_005352837 4866 SRIVPTRTTVECFQDFVVNNTtaQYIFSTINALPDIKCDIVVVDEVSMLTNYELSSVNARLVYnHIVYVGDPYQLPSPRT 4945 White-eye cor...
YP_002308505 4919 SRIVPTRTTVECFQEFVVNNTtaQYIFSTINALPDIKCDIVVVDEVSMLTNYELSSVNARLVYtHIVYVGDPYQLPSPRT 4998 Munia coronav...
YP_005352880 4781 SRIVPTRTTVDCFQDFVVNNTtsQYIFSTINALPDIKCDIVVVDEISMLTNYELSSVNARLVYnHIVYVGDPYQLPSPRT 4860 Common moorhe...
BBC54821     4796 SRIVPTRTTVECFQDFVVNNTiaQYIFSTINALPDIKCDIVVVDEVSMLTNYELSSVNARLVYnHIVYVGDPYQLPSPRT 4875 Falcon corona...
AWV67106     4870 SRIVPTRTTVECFQDFVVNNTtaQYIFSTINALPDIKCDIVVVDEVSMLTNYELSSVNARLVYnHIVYVGDPYQLPSPRT 4949 Sparrow delta...
YP_005352870 4803 TRIVPTRTTVDCFQEFTVNNTsaKYVFSTINALPDIKCDIVVVDEISMLTNYELSSVNARLSYsHIVYVGDPYQLPSPRT 4882 Wigeon corona...
YP_005352862 4864 SRIVPTRTTVECFSDFVVNNTtaKYVFSTINALPDIKCDIVVVDEISMLTNYELSSVNARLSYnHIVYVGDPYQLPSPRT 4943 Night heron c...
AWR88314       92 TRIVPTRTTIDCFQGFAINNThaRYVFSTINALPDIKCDIVVVDEISMLTNYELSTVNARLSYnHIVYVGDPYQLPAPRT 171  Deltacoronavi...
Feature 1                                         #                                               
ACJ12043     4913 MLTTGQLAPaDYNVVTDIMVHTGADVMLDMCYRCPREIVDTVSKLVYDNKLKAAKPNSRQCYKtiinfGSSDIAHEGqSA 4992 Bulbul corona...
YP_002308496 4937 MLTTGQLSPaDYNVVTDIMVHTGADVMLDMCYRCPKEIVETVSKLVYDNKLKAAKPNSRQCYKtivnfGTSDIAHEGqSA 5016 Thrush corona...
YP_005352837 4946 MLTTGQLSPaDYNVVTDIMVHNGADVMLDMCYRCPREIVDTVSKLVYNNKLKAAKPNSRQCFKtiintGSSDIAHEGqSA 5025 White-eye cor...
YP_002308505 4999 MLTSGQLSPaDYNVVTDIMVHAGADVMLDMCYRCPREIVDTVSKLVYDNKLKAAKPNSRQCYKtivnfGPGDIAHEGqSA 5078 Munia coronav...
YP_005352880 4861 MLTTGHLSPaDYNVVTDIMVHTGADVMLDTCYRCPKEIVDTVSKLVYDNKLKAAKPYSRQCYKtiinyGNSDIGHEGqSA 4940 Common moorhe...
BBC54821     4876 MLTTGQLAPaDYNVVTDIMVHTGADVMLDMCYRCPREIVETVSKLVYNSKLKAAKPNSRQCFKtiintGSNDIAHEGqSA 4955 Falcon corona...
AWV67106     4950 MLTSGQLSPaDYNVVTDIMVHAGADVMLDMCYRCPREIVETVSKLVYDNKLKAAKPNSRQCYKtivnfGPGDIAHEGqSA 5029 Sparrow delta...
YP_005352870 4883 MLTGGQLEPtDYNVVTTIMVNAGADVMLDRCYRCPAEIVSTVSKLVYDNKLSSVKPKSHLCYKviinnGNGDISYDGlSA 4962 Wigeon corona...
YP_005352862 4944 MLTSGQLQPvDYNVVTSIMVQAGADVMLNICFRCPAEIVYTVSKLVYDNKLLSAKPASKQCYKvivnnGNNDICYEGcSA 5023 Night heron c...
AWR88314      172 LLTSGQLEPvDYNLVTNIMVNNGADVMLTRCYRCPAEIVNTVSKLVYGCKLEPVKRPSGACYKvl-vnSGNDIMYEGlSA 250  Deltacoronavi...
Feature 1                                                         # #                          #  
ACJ12043     4993 YNEPQLRFALAFRryKRWDNVTFISPYNAMNVKAamaGFSTQTVDSSQGSEYDYVIFCVTTDSAHALNMSRLNVALTRAK 5072 Bulbul corona...
YP_002308496 5017 YNEAQLRFALAFRryKRWENVTFISPYNAMNVKAamaGFSTQTVDSSQGSEYDYVIFCVTTDSAHALNMSRLNVALTRAK 5096 Thrush corona...
YP_005352837 5026 YNEPQLRFALAFRryKRWENVTFISPYNAMNVKAsmaGFSTQTVDSSQGSEYDYVIFCVTTDSAHALNMSRLNVALTRAK 5105 White-eye cor...
YP_002308505 5079 YNEAQLRFALAFRqqKRWDNVTFISPYNAMNVKAamaGFSTQTVDSSQGSEYDYVIFCVTTDSAHALNMARLNVALTRAK 5158 Munia coronav...
YP_005352880 4941 FNEPQLQFALAFRkfKKWDNVTFISPYNAMNVKAamaGFSTQTVDSSQGSEYDYVIFCVTTDSGHALNMSRLNVALTRAK 5020 Common moorhe...
BBC54821     4956 YNEPQLRFALAFRqyKRWENVTFISPYNAMNVKAsmaGFSTQTVDSSQGSEYDYVIFCVTTDSAHAVNMSRLNVALTRAK 5035 Falcon corona...
AWV67106     5030 YNEAQLRFALAFRqqKRWDNVTFISPYNAMNVKAslaGFSTQTVDSSQGSEYDYVIFCVTTDSAHALNMARLNVALTRAK 5109 Sparrow delta...
YP_005352870 4963 YNNPQLEFAIAFRnfKQWSDVTFISPYNAMNTKAaqaGFSTQTVDSSQGSEYNYVIFCVTTDSGHALNMSRLNVALTRAK 5042 Wigeon corona...
YP_005352862 5024 FNQIQLDFALAFVqhKRWTNSTFISPYNAMNVKAsmaGFNTQTVDSSQGSEYDYVVFCVTTDSGHALNMARLNVALTRAK 5103 Night heron c...
AWR88314      251 YNKPQLELACKFRdvKGWHDATFISPYNAMNLKAaslGFSTQTVDSSQGSEYNYVIFCVTTDSGHALNLARLNVALTRAK 330  Deltacoronavi...
Feature 1                               
ACJ12043     5073 VGILVVFRQaNDLYNSLQFESI 5094 Bulbul coronavirus HKU11-796
YP_002308496 5097 IGILVVFRQaNELYNSLQFESI 5118 Thrush coronavirus HKU12-600
YP_005352837 5106 VGILVVFRQaNDLYNSLQFESI 5127 White-eye coronavirus HKU16
YP_002308505 5159 VGILVVFRQaNELYNSLQFEPI 5180 Munia coronavirus HKU13-3514
YP_005352880 5021 IGILVVFRQaNELYQELQFESI 5042 Common moorhen coronavirus HKU21
BBC54821     5036 IGILVVFRQaNDLYNSLQFESI 5057 Falcon coronavirus UAE-HKU27
AWV67106     5110 IGILVVFRQaNELYNSLQFESI 5131 Sparrow deltacoronavirus
YP_005352870 5043 QGILVIFRQkSKLYDQLEFEEL 5064 Wigeon coronavirus HKU20
YP_005352862 5104 IGILVVFRNnDELYKQLEFEEL 5125 Night heron coronavirus HKU19
AWR88314      331 LGILVVFRQrDKLYDSLEFEEL 352  Deltacoronavirus sp.

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