Conserved Protein Domain Family
JMTM_APLP1

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cd21708: JMTM_APLP1 
juxtamembrane and transmembrane (JMTM) domain found in amyloid-like protein 1 (APLP-1) and similar proteins
Amyloid-like protein 1 (APLP-1), also called APLP, may play a role in postsynaptic function. It couples to JIP signal transduction through C-terminal binding. APLP-1 may interact with cellular G-protein signaling pathways. It can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of APLP-1, which consists of the intact transmembrane (TM) domain with adjacent N-terminal juxtamembrane (JM) region.
Statistics
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PSSM-Id: 411991
Aligned: 7 rows
Threshold Bit Score: 136.877
Created: 4-May-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putativeputative
Feature 1:putative homodimer interface [polypeptide binding site]
Evidence:
  • Comment:Based on the structure evidence that Homo sapiens APP forms a homodimer.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        ####               #  ##  ## ##  ##  #  #                                       
P51693       564 EIQRDELAPAGt-gVSREAVSGLLIMGAGGGSLIVLSMLLLRRKkPYGAISHGVVEVDPmltlEEQQLrelQRHGYENPT 642 human
XP_023618113 560 WLVRGGIFWHTt-gVLERAVSGLLIMGAGGGSLIVLSMLLLRRKkPYGAISHGVVEVDPmltlEEQQLrelQHHGYENPT 638 little brown bat
XP_005999229 614 DMQRDELEPDAilnLNRGALIGLLVVALAVAMVIVISLMMVRRR-PYGTISHGIVEVDPmltpEERQLskmQNHGYENPT 692 coelacanth
AAP22957     271 GIQRDELQPDVletFNRGAMVGLLVVAVAIAMVMVISLLLVRRK-PYGTISHGIVEVDPmltpEERQLnkmQNHGYENPT 349 zebrafish
ETE66347     413 EIQRDELEPDTlvtINRGALIGLLIVAVAVAMVIIISLLMVRRK-PYGTISHGIVEVDPmvspEERQLnkmQNHGYENPT 491 king cobra
NP_001120906 557 DIQRDQLEPDTlvtFNRGALIGLLVVAVAVAMVIIISLLLIRRK-PYGTISHGIIEVEAsrspEDKHLskmQNQGYENPT 635 tropical clawed...
NP_001089419 557 DIQRDQLEPDTlvtFNRGALIGLLVVAVAVAMVIIISLLLIRRK-PYGTISHGIIEVEAsrspEDKHLskmQNQGYENPT 635 African clawed ...
Feature 1              
P51693       643 YRFLEE 648 human
XP_023618113 639 YRFLEE 644 little brown bat
XP_005999229 693 YKFFEQ 698 coelacanth
AAP22957     350 YKFFEQ 355 zebrafish
ETE66347     492 YKFFEE 497 king cobra
NP_001120906 636 YRYLEE 641 tropical clawed frog
NP_001089419 636 YRYLEE 641 African clawed frog

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