Conserved Protein Domain Family
JMTM_Notch4
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cd21705: JMTM_Notch4 
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins
Neurogenic locus notch homolog protein 4 (Notch4) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch4, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.
Links
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Statistics
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PSSM-Id: 411988
Aligned: 8 rows
Threshold Bit Score: 89.3732
Created: 16-Mar-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative
Feature 1:putative polypeptide substrate binding site [polypeptide binding site]
Evidence:
  • Comment:Following an initial cleavage by alpha-secretase, the resulting transmembrane domain of Notch is cleaved by gamma-secretase to release the intracellular transcription factor.
  • Comment:Based on the structure evidence that Homo sapiens Notch1 interacts with nicastrin and presenilin-1.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           ###  ###                     ## # ##############     ###                      
Q99466       1425 LPGPLLAVHPHAgtap-------panqLPWPVLCSPVAGVILLALGALLVLQLIRRRRr----eHGALWLPPGFTRRPrt 1493 human
XP_007883689  476 FPFPLEAVAVIHdear-------gllvFRWPLVCVLLAAVAAIALGVLAGVRLTRRREqerrmkHGQLWLPPGFNPSKqp 548  elephant shark
XP_014346906 1711 FPYPLAMAKGIEllqsgtkgpesslplLPRELIYSSIAIALAILLGVFIGVQLARQRKr----qHGALWFPAGFSRHRdp 1786 coelacanth
GCF57355      680 VPYTVVAAWVESakkdpq----avvshFPGPLVYCAVAGVVAVVLGIFLGVWRIRRPQrr---eQGLLWLPPGFAPRQgk 752  Paroedura picta
TFJ95702      377 TPHPLAAVWVEEassdpq----asaprLPWPLLGGLLAGGLALVLGAVVGVQLRRQGTr----kQGVLWLPAGFARPRdp 448  big-headed tu...
XP_030053134 1665 LPFPLVAAKHENnemel-----ytsaqPPWKLISSSVAVGLAVVLGILIGVHLSRRRKr----eHGALWFPAGFTRHRdp 1735 Microcaecilia...
OCT66174     1750 LPYSLLGVTYKDtdkndi----lvatqLPWPLVWASVAVGVALVLGGFIGVQLSRKRQ------HGVLWLPSGFSRHRsg 1819 African clawe...
XP_023422379 1475 LLFRFLAATVAVgalepl----lpgalLAVHPSTGTVVGVLLLALGALLVLQLIRRRRrr---eHGALWLPPGFIRKPrt 1547 domestic guin...

Feature 1                               
Q99466       1494 qsaphRRRPPLGEDSIGLKALK 1515 human
XP_007883689  549 r--nySRREPVGQDSIAMRILN 568  elephant shark
XP_014346906 1787 n--dhRRREPVGEDAIGMKCLK 1806 coelacanth
GCF57355      753 k--rrCRREPVGEDAIGLKPRK 772  Paroedura picta
TFJ95702      449 n--arRRRDPVGEDAIGLKPLK 468  big-headed turtle
XP_030053134 1736 n--drRRREPVGEDAIGLKPLK 1755 Microcaecilia unicolor
OCT66174     1820 d--giRRREPVGEDATRLRPLK 1839 African clawed frog
XP_023422379 1548 qqaphRRRPPLGEDSIGLKALK 1569 domestic guinea pig

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