6IDF


Conserved Protein Domain Family
JMTM_Notch
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cd21701: JMTM_Notch 
juxtamembrane and transmembrane (JMTM) domain found in Notch protein family
Neurogenic locus notch homolog (Notch) proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway. They operate in a variety of different tissues and play a role in a variety of developmental processes by controlling cell fate decisions. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch proteins, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.
Links
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Statistics
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PSSM-Id: 411984
Aligned: 14 rows
Threshold Bit Score: 72.4127
Created: 30-Sep-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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polypeptide
Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:polypeptide substrate binding site [polypeptide binding site]
Evidence:
  • Comment:Following an initial cleavage by alpha-secretase, the resulting transmembrane domain of Notch is cleaved by gamma-secretase to release the intracellular transcription factor.
  • Structure:6IDF: Homo sapiens Notch1 in complex with nicastrin and presenilin-1; contacts at 4A
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          ###  ###                    ## # #########   ########                          
6IDF_E          1 MVQSETVECPp----------PAQLHFMYVAAAAFVLLFFVGCg--VLLSRKRRrqHGQLWFPEGFKVSEask------k 62   human
P07207       1719 DFQIHSVRGIknpgd-edngePPANVKYVITGIILVIIALAFFg-mVLSTQRKRa-HGVTWFPEGFRAPAavm-----sr 1790 fruit fly
Q99466       1426 PGPLLAVHPHagtap--panqLPWPVLCSPVAGVILLALGALLv--LQLIRRRRreHGALWLPPGFTRRPrtqs---aph 1498 human
XP_029105030  660 SFPIYSVKGVpq--------ePAAQVNLFYLVAVGVLILLLVLg--ALAAKRRRk-HGALWLPEGFLIKGs--------- 719  Asian bonytongue
AKR17062     1278 PYPVYQVRAEkeddaaptkstPPAGLSPLYIAMLCVGIPLFVVg--VLAGAKRV--YAKLWVPEGFPRHRprrq----ps 1349 hammer coral
XP_028407580 1299 GEPFKIGTENpgd------ekPPESMSPLFIAILCVTIPLIVVg--VLVGGKRV--FAKLWLPEGFPTRHvrr-----rs 1363 Dendronephthy...
ARX80207      576 PVPVLAVRGTkgps---akdsSKTHLSPLLIGLIVVAVPCFVI---VMVVTGKRt-YGALWAPEGHRQHRaqg------m 642  Hydractinia e...
NP_001037825 1667 EFPINTVASTtnp------tpPPQDYTYIVGAAGGVVLVIVIIg--VLTHRKRKreTSTLWAPEGFNVTKk--------- 1729 vase tunicate
CAC19873     1669 SYPVKSLYSGedpa---ppttQPFNPLYVVVAAVGILLVMVGLg--VLMTTKRRreSGQLWYPEGFKLTKesrkdarrst 1743 Florida lancelet
ACY92600      536 GFPVQGAGSTdedi---itaqLPNKLVWVLVAGVAIVLVVVVLgviVSTARKRKa-HGTLWYPENFNKFVckpenprrrs 611  Saccoglossus ...

Feature 1                         
6IDF_E         63 kRREPLGEDSVGLKPL 78   human
P07207       1791 rRRDPHGQEMRNLNKQ 1806 fruit fly
Q99466       1499 rRRPPLGEDSIGLKAL 1514 human
XP_029105030  720 rRREPVGQDELDLTDI 735  Asian bonytongue
AKR17062     1350 tRRDPVGQEVSMRSMS 1365 hammer coral
XP_028407580 1364 qRRDPVGEDSAEKSSV 1379 Dendronephthya gigantea
ARX80207      643 rREPGVGQEGEELTSL 658  Hydractinia echinata
NP_001037825 1730 qRREPIGQDDLNGLNG 1745 vase tunicate
CAC19873     1744 rRRDPVGQEVGMKSFT 1759 Florida lancelet
ACY92600      612 rRKEPVGEDSVGMRRM 627  Saccoglossus kowalevskii

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