7JX6,7JTL


Conserved Protein Domain Family
ORF8-Ig_SARS-CoV-2-like
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cd21641: ORF8-Ig_SARS-CoV-2-like 
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SARS-CoV-2 ORF8 immunoglobulin (Ig) domain protein and related proteins
This subfamily includes the ORF8 immunoglobulin (Ig) domain protein of Severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2, also known as a 2019 novel coronavirus, 2019-nCoV) and related Sarbecovirus ORF8 proteins. SARS-CoV-2 causes the disease called "coronavirus disease 2019" (COVID-19). SARS-CoV-2 ORF8 (also known as ns8 and accessory protein 8) is a fast-evolving protein in SARS-related CoVs, and a potential pathogenicity factor which evolves rapidly to counter the immune response and facilitate the transmission between hosts. A 382 nucleotide deletion in SARS-CoV-2 ORF8 was found to correlate with milder disease and a lower incidence of hypoxia. SARS-CoV-2 ORF8 interacts with a variety of host proteins, including many factors involved in ERAD. It disrupts IFN-I signaling when exogenously overexpressed in cells, and downregulates MHC-I. It belongs to a family which includes Sarbecovirus ORF8 proteins classified as type II, such as bat coronavirus Rf1 ORF8, and those classified as type III, such as Bat SARS coronavirus HKU3-1 ORF8.
Links
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Statistics
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PSSM-Id: 439222
Aligned: 5 rows
Threshold Bit Score: 196.422
Created: 22-Apr-2020
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Comment:a disulfide-linked dimer interface
  • Structure:7JX6: SARS-CoV-2 ORF8 protein forms a homodimer; contacts at 4A
  • Structure:7JTL: SARS-CoV-2 ORF8/NS8 forms a homodimer; contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #######                         #####                                           
7JX6_A         1 QECSLQSCTQHQPYVVDDPCPIHFYSKWYIRVGARKSAPLIELCVDEaGSKSPIQYIDIGNYTVSCLPFTINCQEPKLGS 80  Severe acute re...
7JTL_A         4 QECSLQSCTQHQPYVVDDPCPIHFYSKWYIRVGARKSAPLIELCVDEaGSKSPIQYIDIGNYTVSCLPFTINCQEPKLGS 83  Severe acute re...
AVP78037      18 QECSLQSCAQHQPYVVDDPCPIHFYSRWYIRVGARKSAPLIELCVDEvGSKSPIQYIDIGNYTVSCSPFTINCQEPKLGS 97  Bat SARS-like c...
QHR63307      18 QECSLQSCAQHQPYVVDDPCPIHFYSKWYIRVGARKSAPLIELCVDEvGSKSPIQYIDIGNYTVSCSPFTINCQEPKLGS 97  Bat coronavirus...
YP_009724396  18 QECSLQSCTQHQPYVVDDPCPIHFYSKWYIRVGARKSAPLIELCVDEaGSKSPIQYIDIGNYTVSCLPFTINCQEPKLGS 97  Severe acute re...

Feature 1                         # #### 
7JX6_A        81 LVVRCSFYEDFLEYHDVRVVLDFI 104 Severe acute respiratory syndrome coronavirus 2
7JTL_A        84 LVVRCSFYEDFLEYHDVRVVLDFI 107 Severe acute respiratory syndrome coronavirus 2
AVP78037      98 LVVRCSYYEDFLEYHDIRVVLDFI 121 Bat SARS-like coronavirus
QHR63307      98 LVVRCSFYEDFLEYHDVRVVLDFI 121 Bat coronavirus RaTG13
YP_009724396  98 LVVRCSFYEDFLEYHDVRVVLDFI 121 Severe acute respiratory syndrome coronavirus 2

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