7JX6,7JTL


Conserved Protein Domain Family
ORF8-Ig_SARS-CoV-2-like
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cd21640: ORF8-Ig_SARS-CoV-2-like 
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SARS-CoV-2 ORF8 immunoglobulin (Ig) domain protein and related proteins
This family includes the ORF8 immunoglobulin (Ig) domain protein of Severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2, also known as a 2019 novel coronavirus, 2019-nCoV) and related Sarbecovirus ORF8 proteins including those classified as type II, such as bat coronavirus Rf1 ORF8, and those classified as type III, such as Bat SARS coronavirus HKU3-1 ORF8. SARS-CoV-2 causes the disease called "coronavirus disease 2019" (COVID-19). SARS-CoV-2 ORF8 is a fast-evolving protein in SARS-related CoVs, and a potential pathogenicity factor which evolves rapidly to counter the immune response and facilitate the transmission between hosts. A 382 nucleotide deletion in SARS-CoV-2 ORF8 was found to correlate with milder disease and a lower incidence of hypoxia. SARS-CoV-2 ORF8 interacts with a variety of host proteins, including many factors involved in ERAD. It disrupts IFN-I signaling when exogenously overexpressed in cells, and downregulates MHC-I.
Links
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Statistics
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PSSM-Id: 439221
Aligned: 4 rows
Threshold Bit Score: 158.559
Created: 13-Oct-2021
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Comment:a disulfide-linked dimer interface
  • Structure:7JX6: SARS-CoV-2 ORF8 protein forms a homodimer; contacts at 4A
  • Structure:7JTL: SARS-CoV-2 ORF8/NS8 forms a homodimer; contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1     #######                          #####                                          
7JX6_A      1 QECSLQSCTQHQPYVVDDPCPIHFYSKWYIRV-GARKSAPLIELCvdeaGSKSPIQYIDIGnytVSCLP-FTINCQEPKL 78  Severe acute respi...
7JTL_A      4 QECSLQSCTQHQPYVVDDPCPIHFYSKWYIRV-GARKSAPLIELCvdeaGSKSPIQYIDIGnytVSCLP-FTINCQEPKL 81  Severe acute respi...
Q0Q469     18 KECSIQECCENQPYQIEDPCPIHYYSDWFIKI-GSRKSARLVQLCegdyGKRIPIHYEMFGnytISCEP-LEINCQAPPV 95  Bat CoV 279/2005
AAZ67036   16 IRTVVQRCASNTPYVLENPCPTGYQPEWNIRYnTRGNTYNSARLCa--lGKVLSFHRWHTMv--QACTPnVTINCQDPVG 91  Bat SARS CoV Rf1/2004

Feature 1                        # #### 
7JX6_A     79 GSLVVRCSFYEDfleyHDVRVVLDFI 104 Severe acute respiratory syndrome coronavirus 2
7JTL_A     82 GSLVVRCSFYEDfleyHDVRVVLDFI 107 Severe acute respiratory syndrome coronavirus 2
Q0Q469     96 GSLIVRCSYDYDfvehHDVRVVLDFI 121 Bat CoV 279/2005
AAZ67036   92 GALVARCWYFYQgpqtATFRDIHVDL 117 Bat SARS CoV Rf1/2004

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