5OSG,5OPT


Conserved Protein Domain Family
RRM2_KSRP

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cd21614: RRM2_KSRP 
Click on image for an interactive view with Cn3D
RNA recognition motif 2 (RRM2) found in Kinetoplastid-Specific Ribosomal Protein (KSRP) and similar proteins
KSRP is an essential protein located at the solvent face of the 40S subunit, where it binds and stabilizes kinetoplastid-specific domains of rRNA, suggesting its role in ribosome integrity. It also interacts with the kinetoplastid-specific C-terminal region of protein eS6. KSRP contains two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). The model corresponds to the second RRM motif.
Statistics
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PSSM-Id: 410193
Aligned: 4 rows
Threshold Bit Score: 169.365
Created: 24-Feb-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
RNA binding
Conserved site includes 39 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Structure:5OSG; Leishmania donovani KSRP together with 40S ribosomal protein S6 binds 18S rRNA, contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1     #        #  # ####### # #      #  # ####### #                     # #  #  ####  
5OSG_h    130 DAHENSSCVFVSPIFRPSTTKAQVMELFAGVKVQRLRMYRQNFAYAYLDSPAAAKKFVEEKNGTAFRGHTLRVALSARSL 209 Leishmania donovani
5OPT_h    151 DPHANSSVVFVSPIFRASTTKKQILELFSGMKVLRLRTYRNNYAYVYLDTPAAAQRAVKEKNGAEFRGKQLRVALSTRSL 230 Trypanosoma cruzi ...
CUG93364  128 DKHDASSVVFVGPIFRENTTRKQLFEFFAGSKIVKLRRYEHNYAYVYLDSAATAQKVIKEKNGATFHGKVLTVKPSTRSL 207 Bodo saltans
RNF25302  146 DPHANSSVVFVSPIFRASTTKKQILELFSGMKVLRLRTYRNNYAYVYLDTPAAAQRAVREKNGAEFRGKQLRVALSTRSL 225 Trypanosoma cruzi
Feature 1      ##  ##  # ### ##
5OSG_h    210 eKLRARQEVANVVIAAH 226 Leishmania donovani
5OPT_h    231 aKDRARAERARLLMAAQ 247 Trypanosoma cruzi strain CL Brener
CUG93364  208 eQEKARNEHSKQLIEIH 224 Bodo saltans
RNF25302  226 aKDRARAERARLLIAAQ 242 Trypanosoma cruzi

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