5OSG,5OPT


Conserved Protein Domain Family
RRM1_KSRP
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cd21613: RRM1_KSRP 
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RNA recognition motif 1 (RRM1) found in Kinetoplastid-Specific Ribosomal Protein (KSRP) and similar proteins
KSRP is an essential protein located at the solvent face of the 40S subunit, where it binds and stabilizes kinetoplastid-specific domains of rRNA, suggesting its role in ribosome integrity. It also interacts with the kinetoplastid-specific C-terminal region of protein eS6. KSRP contains two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). The model corresponds to the first RRM motif.
Links
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Statistics
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PSSM-Id: 410192
Aligned: 4 rows
Threshold Bit Score: 104.611
Created: 19-Feb-2020
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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RNA binding
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Structure:5OSG; Leishmania donovani KSRP together with 40S ribosomal protein S6 binds 18S rRNA, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #  #                           ##      #   #####  #               #####
5OSG_h        55 NGVYVKNWGtGSVADATNVFSAAGKVVKVQLRRqRYALVFFENSAAVKKAIDLFNEKEVLGQTVLVVPAKA 125 Leishmania donovani
5OPT_h        76 NGLYVKNWGqGSVDDARALFGTAGKVVGVRVRRrRYAIIFFENAAAVKKAIDLFNGKEFMGNVLSVVPAKT 146 Trypanosoma cruzi strain...
XP_011780708  57 NGVYVKNWGqGSVTDATRIFSAAGKVVSAQIRRrRYAIIFFENAAAVRKAIDLFNEKEVLGAKVTVSPAKT 127 Trypanosoma brucei gambi...
CUG93364      53 NGVYVKNWGqGSVADATAAFSAAGKVSHVQIRRgKYALVFFENSAAVKKAVDSFNGKEVNGTTVIVTAAKT 123 Bodo saltans

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