2MZT,2MZQ


Conserved Protein Domain Family
RRM3_HRB1_GBP2

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cd21607: RRM3_HRB1_GBP2 
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RNA recognition motif 3 (RRM3) found in Saccharomyces cerevisiae protein HRB1, G-strand-binding protein 2 (GBP2) and similar proteins
The family includes Saccharomyces cerevisiae protein HRB1 (also called protein TOM34) and GBP2, both of which are SR-like mRNA-binding proteins which shuttle from the nucleus to the cytoplasm when bound to the mature mRNA molecules. They act as quality control factors for spliced mRNAs. GBP2, also called RAP1 localization factor 6, is a single-strand telomeric DNA-binding protein that binds single-stranded telomeric sequences of the type (TG[1-3])n in vitro. It also binds to RNA. GBP2 influences the localization of RAP1 in the nuclei and plays a role in modulating telomere length. Members in this family contain three RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). The model corresponds to the third RRM motif.
Statistics
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PSSM-Id: 410186
Aligned: 14 rows
Threshold Bit Score: 133.604
Created: 19-Feb-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2MZT_A        20 RNRLIYCSNLPFSTAKSDLYDLFetIGKVNNAELRydskGAPTGIAVVEYDnVDDADVCIERLNNYNYGGCDLDISYAK 98  Saccharomyces ce...
P38922       374 RNRLIYCSNLPFSTAKSDLYDLFetIGKVNNAELRydskGAPTGIAVVEYDnVDDADVCIERLNNYNYGGCDLDISYAK 452 Saccharomyces ce...
SCU90805     328 KSNTLYVDNLPYATAKSDLFDLFeiIGPVNRAELRldstGEPTGVAVVEYEdIENAETCISRLDKYSYGGRELSISYVR 406 Lachancea meyers...
XP_003675837 297 RNNTVYCNNLPLSTTVPDLYDLFgsVGEIAMAELVydetGTSTGAAVVEYAsQDAADVCINKLNGYNYGGRDLHITYAS 375 Naumovozyma cast...
XP_003980080 279 RNPTVFCQSLPLSTTVPDLYDLFgsFGDINHAELIydtnGLSTGSAVVEYMsADYAEMCIDKLNNYNYGGHQLDISFAH 357 Naumovozyma dair...
SCW02593     357 ENKVIYVENLPLATAKSDLFDLFetIGKVTNAEIFy---HDKSGSAYVEYEnEEDAKVSIKRLNNYTYGGHDLIIGFAK 432 Lachancea fermen...
OEJ92408     421 KSKIVYVSNLPLSTAQSDLYDLFdtFGKVNRAELKlv-dGDVNGEAVVKYDnLDSAEMCVDRLDKYVYGGCELHLSFST 498 Hanseniaspora os...
XP_003959138 342 KTNLVYISNLPFATSIDDLYDLVesLGNVVHAELKfdetGSPTGVAIVEYEdMDYAETAMEKLNDYNYGGNELSVSYAQ 420 Kazachstania afr...
SMN21937     347 RNSLVYCTGLPLSTSANDLYELFesLGRVHHAELSydstGAPTGAAVVDYEdISSADLCVSKLNNYNYGGQDLSVSFAQ 425 Kazachstania sau...
KTB17801     359 KSKIILCDNLPGATTEGDLYDLFetLGKVKTAGFIntdnAGETVSAIVIYNeQDDAEVCYGRLQGYNYGGCDLKISYVK 437 [Candida] glabrata
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