6EXX


Conserved Protein Domain Family
RRM4_PES4_MIP6

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cd21604: RRM4_PES4_MIP6 
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RNA recognition motif 4 (RRM4) found in Saccharomyces cerevisiae protein PES4, protein MIP6 and similar proteins
The family includes PES4 (also called DNA polymerase epsilon suppressor 4) and MIP6 (also called MEX67-interacting protein 6), both of which are predicted RNA binding proteins that may act as regulators of late translation, protection, and mRNA localization. MIP6 acts as a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores. It interacts with MEX67. Members in this family contain four RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). The model corresponds to the fourth RRM motif.
Statistics
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PSSM-Id: 410183
Aligned: 14 rows
Threshold Bit Score: 128.946
Created: 19-Feb-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6EXX_A         1 KISTLFLENLSaVCNKEFLKYLCHQEnIRPFKIQIDGYDENSSTYSGFIKFRnFEDATRIFNFLNnRLVGGSIVTTSWE 79   Saccharomyces c...
XP_003673837 383 GNRTVYLNNVSvVCNQEFLRRLCLQEgIKAQKIYLKPDDHDSYSCSGYIKCNsKDNAKRVFEILNgKFIGGCYIHVSWD 461  Naumovozyma cas...
BAP69624     575 YKKTVYLTNLSvICNEEFLKFFCTQErIKTERIVIRYYDDKTDTYSGYVKCNsRNDAQRLFDLMEnKLLGDSEVKASWQ 653  Kluyveromyces m...
CDH12287     400 YRCTIFLQNLSsICNEQFLTQMCIQErIKIVGLEITTFYEESLTYAGYVKCRsKNDAHKMFELLNnRLIGGCVVKVTWG 478  Zygosaccharomyc...
SCU90973     411 YRQTLYLSNLSsICNEEFLMQLCITEkIGYKQIIIDHYDETSLTFVGQVRCNsRPDANRLFESLNnKLVGDCFVKVSWR 489  Lachancea meyer...
XP_003980256 396 DKKTVYLKNLSpICNERFIERICLQErIRVQKISVDPISPDILTNTGFVTCKtEVDANKLFNFMDkRLIGGCSVQVSWQ 474  Naumovozyma dai...
GAV55401     406 YRPILYLQNLSsVCNEQFLFQMCMEErIKIENLAITDFVHDSFTYSGYVKCKtKKDADKISKLLNnRLIGGCEVKVTRK 484  Zygosaccharomyc...
CUS21005     419 YRQTLYLSDMSaVCNQKFLGHLCRIEkIRFQKIAIDRYDKESLTFGGSILCKsRPDANRLFEVLNgKLIGDSIVKVSWR 497  Lachancea quebe...
NP_984845    437 YKLTVYLSSLSsICSEQFLQCFCAEErIKTKRISIRFYDEATLTFSGFVQCQtRNDANRLFELLNnKLLGDSTVKASWK 515  Eremothecium go...
XP_003956566 366 KSNILYLSNLCvICDSKFLKQICMQEgVKFDTIEITTYDPTSMTYSGFIKCKkYKDTEKLFKYLDgKLIGGCITKVTSQ 444  Kazachstania af...
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