Conserved Protein Domain Family
RRM2_PES4_MIP6

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cd21602: RRM2_PES4_MIP6 
RNA recognition motif 2 (RRM2) found in Saccharomyces cerevisiae protein PES4, protein MIP6 and similar proteins
The family includes PES4 (also called DNA polymerase epsilon suppressor 4) and MIP6 (also called MEX67-interacting protein 6), both of which are predicted RNA binding proteins that may act as regulators of late translation, protection, and mRNA localization. MIP6 acts as a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores. It interacts with MEX67. Members in this family contain four RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). The model corresponds to the second RRM motif.
Statistics
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PSSM-Id: 410181
Aligned: 12 rows
Threshold Bit Score: 143.708
Created: 25-Feb-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P39684       180 NVFFSNLPLNNpllTTRVFYDTFSrYGKILSCKLDsRKDIGFVYFEDEkTARNVIKMYNNTsFFGKKILCGIHFDK 255  Saccharomyces cere...
XP_003673837 181 NVFFANLPLENkhlTTRAFYDTFKgYGEILSCKLDkRKNIGFVYFDNDkPAQMVINDFNNKiYFGNKIICGLHFDK 256  Naumovozyma castel...
BAP69624     302 NVFFSNLPLDNnrfTTRVFYDEFKkFGKILSCKLDrRKNIGFIYFENDaAAKEAIRQYNGKqLFDTNIMCGVHFDR 377  Kluyveromyces marx...
GAV55401     191 NVFFSNLPLENanlTTRVFYDTFKiYGNILSCKLDkRKNIGFIYFDNDhAARVVIKEFNGKeFFGNKVSCGIHFDK 266  Zygosaccharomyces ...
SCU90973     186 NVFFANLPLENpnlTTRAFYETFNhYGRVLSCKLErRKNIGFVYFESDaVAKKVIEELNDTeFYGNKISCGLHFDK 261  Lachancea meyersii...
XP_003980256 190 NVFFSNLPLENkqlTTRKFYDTFKkYGEILSCKLDsRKNIGFVYFENDkAALQAIKDYNNKvFFGNKIICGIHFDK 265  Naumovozyma dairen...
CDH12287     187 NVFFSNLPLENpdlTTRVFYDTFKiYGNILSCKLDkRKNIGFVYFDSDyAARVVIKEFNGKeFFGTKVLCGIHFDK 262  Zygosaccharomyces ...
CUS21005     184 NVFFSNLPLENpalTTRVFYESFReYGRVLSCKLDrRKNIGFVYFESDvCAKKAIDAFNSKeYFGSKIACGLHFDK 259  Lachancea quebecensis
XP_003681020 186 NVFFSNLPLEDsrlTTRVFYDTFKkYGKILSCKLDkRKDIGFIYFNNDqSARKVIKDYNGKeFFGNKVLCGIHFDK 261  Torulaspora delbru...
NP_984845    205 NVFFSNLPLENlalTTRVFYDAFKkFGKILSCKLDrRKNIGFVYFEKDsAAKQAIAEYNGKeFFGNNILCGIHFDR 280  Eremothecium gossy...
XP_003956566 178 NVYFRNLPTENnmlTTRYFYDSFRkYGKILSCKIErSKKIGFIYFACEvTANEVIKKFNNSsFLGNNIYCGLHFDK 253  Kazachstania afric...
P38760       200 NVFFSNLPLENpqlTTRSFYLIMIeYGNVLSCLLErRKNIGFVYFDNDiSARNVIKKYNNQeFFGNKIICGLHFDK 275  Saccharomyces cere...
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