2N6D


Conserved Protein Domain Family
RRM2_GNPTAB
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cd21600: RRM2_GNPTAB 
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RNA recognition motif 2 (RRM2) found in N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTAB) and similar proteins
GNPTAB, also termed GlcNAc-1-phosphotransferase subunits alpha/beta, or stealth protein GNPTAB, or UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta, catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment. The model corresponds to the RNA recognition motif 2 (RRM2) of GNPTAB. Its functional significance remains to be investigated.
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Statistics
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PSSM-Id: 410179
Aligned: 21 rows
Threshold Bit Score: 79.9627
Created: 16-Nov-2018
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2N6D_A         93 DLAFLSGFPptfk--etnQLKTKLPENLSsKVKLLQLy-----sEASVALLKLNnpkDFQELNKQtk-knMTIDGKELTI 164  human
ELT93014      219 DTVIVAGIPegt---dkeKVLESLPAQYKtVITQVEIh-----lEKAVAVLTLSntdQSDALAQVi---tHEVPLTHPML 287  Capitella teleta
XP_006821287  230 NTIIMTGLPkdm---eddEIWKVLPENFRqNVEFVDLy-----eKRGLAVISLTdkqAVHSFLSQse--lYYGEDSEIKV 299  Saccoglossus ...
XP_015930221  213 NMFMISAISsvl---skeNTLDKLPLDIRpSISKVNIy-----eEKNLAIFISSdkeVVNSALKLs---nITLENKVSVI 281  common house ...
KOF94489      225 DVIIMSGIPfkh---gmkNVKNFFPSVYQdVFSKVVSf-----eDKGVAVLHVKtkaVFEEVLQLn----LTISEKIISF 292  Octopus bimac...
PVD33947      170 DSILMTGFPnef---tsdRLLSVLPGEHRrNVVQVELh-----aDKGVAVLHMAgakETEAVLHLk---nFTIEGKTPTF 238  Pomacea canal...
XP_002609190  165 DTVMVTHLPrqg----eqEVKSMLEDKFReKVSSVEVy-----lEKRVAVMDVPdfnDMDLLLKDgdvtnVTIGNDTIRL 235  Florida lancelet
KFM76286       90 TMVFLTQVPssv---sdtDILEKLPENIKsSVSKVNIh-----aEKSLAVLILNdpdMINSIIKLn---nITFESKVASI 158  Stegodyphus m...
XP_021926152  160 NTVLISGIPstlleerrsILHADLKKHMQsNIEHLWVy-----sEKRLVVVKVDtaeTVNRIVQLtn--rMTIGGSVVNI 232  Zootermopsis ...
XP_002408193  211 DMLMIVGIPsgv---setDIAQKLSGTSQeTIVKVKTfqihlyqNESLALLVTSgkaATDALSKAn----VSLKSRLASI 283  black-legged ...

2N6D_A        165 SPAYLLWD 172  human
ELT93014      288 KVLFVAFR 295  Capitella teleta
XP_006821287  300 TTGNLVWL 307  Saccoglossus kowalevskii
XP_015930221  282 SPVYLVVQ 289  common house spider
KOF94489      293 AAASIVWD 300  Octopus bimaculoides
PVD33947      239 TLARLVWD 246  Pomacea canaliculata
XP_002609190  236 TAASLAWD 243  Florida lancelet
KFM76286      159 APAHLVIE 166  Stegodyphus mimosarum
XP_021926152  233 SKAYLILE 240  Zootermopsis nevadensis
XP_002408193  284 SRVFLVLE 291  black-legged tick
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