5WFC,5M5G,5KKL,5VK3


Conserved Protein Domain Family
VEFS-box_ctSUZ12-like
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cd21552: VEFS-box_ctSUZ12-like 
Click on image for an interactive view with Cn3D
VEFS (VRN2-EMF2-FIS2-Su(z)12) box found in Chaetomium thermophilum suppressor of zeste 12 protein (ctSUZ12) and similar proteins
SUZ12 is a Polycomb group (PcG) protein that acts as a component of the Polycomb Repressive Complex 2 (PRC2), a histone methyltransferase complex composed of core subunits EZH2 (or EZH1), EED, SUZ12 and Rbbp4. PRC2 trimethylates histone H3K27 (H3K27me3) to mark developmentally repressed chromatin. This model corresponds to the VEFS (VRN2-EMF2-FIS2-Su(z)12) box at the C-terminus of SUZ12, which is responsible for binding to EED and EZH2 (or EZH1).
Links
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Statistics
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PSSM-Id: 439217
Aligned: 97 rows
Threshold Bit Score: 92.2404
Created: 8-Apr-2020
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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putative trimer
Conserved site includes 56 residues -Click on image for an interactive view with Cn3D
Feature 1:putative trimer interface [polypeptide binding site]
Evidence:
  • Comment:based on the structure of human Suz12 VEFS-box in complex with histone-lysine-N-methyltransferase EZH2 and polycomb protein EED
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #########   # ### ##       #### # #  #   # #     ##   #  ##  #       #####      
5WFC_B        803 QPLFDPLSKVQLLPGQPLPQHp---iDDSWLLLKHRDNLQDFIDl--rPEEKEFLQEWDAFILRr-hISSEQYLPRYFLR 876  Chaetomium th...
XP_007293392  634 KPLYEATTKRLLKPGDELPKSdd-etDEAWLHQSQRDGLNDFTDedvlPEEKDFMHRWNSFVVNe-hLTSDKYLATVVVR 711  Marssonina br...
CZT48959      606 HPLYDTVSKRLLSSNEILTTSds-dtDETWLHQARRDGINDFTDi--sPEEKEYINKFNPFVFSe-rLTSTKYFPNAMLR 681  leaf blotch o...
PBP23775      635 KPLYDTITKRLLRTGDQLADEde-etDEAWLHLKQKDAINDFEEavvlPEEKEFINCWNPFVVSh-hLTSDKQLQPVFVR 712  Diplocarpon r...
RDW95355      588 SQLYHPVTRRRLKAGEIIDNSed-enDERWLNQKHRDIIMDYTNi--tDAEKDYVVRWNPFITMl-kLTCDKYMPKVIVR 663  Coleophoma cr...
EHL00613       16 KPLFHTITKKALRPGDDLSSSde-ekDEAWLEHKHRDIIYDFSDi--gFEEKEYINRWNPFITQk-qYSTRTYLPQAIAE 91   Glarea lozoye...
KFY72971      591 KPLYDIATKRVLKPGEPLPPSt---vSQDWRIRKQAELINNISDm--tPAEKEFINRWDPFIFGq-kLTSKIFMPTILKE 664  Pseudogymnoas...
APA13559      332 RVFYDLRTKRVLQPGEELPDSdd-ekDEAWLLHKRKCIINEFTDl--tDDEKEYFIKWEEFIMGe-rQTGLSHLQETIMR 407  Sclerotinia s...
OQO00067      502 IRFYAPISKRPLTPGSLLPSLnsssiNLTWLSQRLHDDINDLPIs---DATKEFWKAWNAHLDSe-nLCGEVYLAGSLER 577  Rachicladospo...
KAA8564498    580 ELPVKSKKSGFLKPGEELPDSdd-ekDETWLLHKRKWIINDYTDi--sDDEKEYLIKWEEFIMAerfTTNMSHLSGYHHE 656  Monilinia fru...

Feature 1                                                      #### ### #########         #  ##   
5WFC_B        877 FVREKadwl-------------------------------vskrSRGEEFSKLVATLLARRVLp--------ERVVIEAT 917  Chaetomium th...
XP_007293392  712 FVEANkawl-------------------------------vektSRRKEFMKQAENFILKGIFd--------ERRLRHCL 752  Marssonina br...
CZT48959      682 FARGNkdwl-------------------------------vekvERRMEFSKHIESFVLRGEMd--------EETLERCI 722  leaf blotch o...
PBP23775      713 FVERNktwl-------------------------------aekrARMMELMKHAHNLVMKRVId--------ERCLQRCV 753  Diplocarpon r...
RDW95355      664 FVSENklwf-------------------------------lcreERIREFCKHAEALMLRGSMd--------GVTWTQCM 704  Coleophoma cr...
EHL00613       92 FMEKHktwl-------------------------------vekdSRKAEFVKQCETFILRGDIt--------EGHLDELL 132  Glarea lozoye...
KFY72971      665 FINVNrewl-------------------------------deeqCRKKELLKHLATLKMSGRIq--------EECLWECL 705  Pseudogymnoas...
APA13559      408 FVSRNrvwf-------------------------------aekkARKKEWCKQIELFVARDGLa-------dQPLMSRCE 449  Sclerotinia s...
OQO00067      578 FKQKWrte---------------------------------tagRWKDDFHEFVKRLARHGIVgqeasdallSDTANALT 624  Rachicladospo...
KAA8564498    657 IRGEKialvvcarnlcpdphyhkecaersnrslmpkgtwlcdrcHREANLEANLEAHFSRVVVnte----llRRDFRDRI 732  Monilinia fru...

Feature 1         #  #  
5WFC_B        918 QVLNDA 923  Chaetomium thermophilum var. thermophilum DSM 1495
XP_007293392  753 GVIEEE 758  Marssonina brunnea f. sp. 'multigermtubi' MB_m1
CZT48959      723 RILEAK 728  leaf blotch of barley
PBP23775      754 NLVSAE 759  Diplocarpon rosae
RDW95355      705 QILKLA 710  Coleophoma crateriformis
EHL00613      133 ARLKVE 138  Glarea lozoyensis 74030
KFY72971      706 EMFQTE 711  Pseudogymnoascus sp. VKM F-103
APA13559      450 RIFELG 455  Sclerotinia sclerotiorum 1980 UF-70
OQO00067      625 NVIGDY 630  Rachicladosporium antarcticum
KAA8564498    733 PVVRRK 738  Monilinia fructicola

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