5HYN,5IJ7,5WG6


Conserved Protein Domain Family
VEFS-box_SUZ12
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cd21551: VEFS-box_SUZ12 
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VEFS (VRN2-EMF2-FIS2-Su(z)12) box found in suppressor of zeste 12 protein (SUZ12) and similar proteins
SUZ12, also called chromatin precipitated E2F target 9 protein (ChET 9 protein), or joined to JAZF1 protein, is a Polycomb group (PcG) protein that acts as a component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. This model corresponds to the VEFS (VRN2-EMF2-FIS2-Su(z)12) box at the C-terminus of SUZ12, which is responsible for binding to EED and EZH2.
Links
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Statistics
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PSSM-Id: 439216
Aligned: 43 rows
Threshold Bit Score: 106.523
Created: 6-Apr-2020
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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trimer
Conserved site includes 60 residues -Click on image for an interactive view with Cn3D
Feature 1:trimer interface [polypeptide binding site]
Evidence:
  • Structure:5HYN; Homo sapiens Suz12 VEFS-box in complex with histone-lysine-N-methyltransferase EZH2 and polycomb protein EED, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #########   #  ### ##      #### # #  #   # #  ###   #  ##  #           #######  
5HYN_C          7 RLYFHSDTCLPLRp-QEMEVDSEdekDPEWLREKTITQIEEFSDvnEGEKEVMKLWNLHVMKh-------gFIADNQMNH 78   human
VDM30234      759 RVYFHTTTLQPIEptAFDDCDSEdedAPQWLRDHYQRKVEEFTDvnKGEKEFMQIWNAFLLSirp---setVVSDSQMGH 835  Hydatigera ta...
PAA80430      553 RQYFHSQTCVPLLp-QEIDADSEdeiAPDWLRQKYSRNLEDFTDvnEGEKAVMMAWNLHVMTweg----gpVTGQHQLPQ 627  Macrostomum l...
CDS33784      693 RKFYHSSTLQQIT--AGDNYDSEeeeSAKWLRDQYQRRVQEITDvnKGEKELMQIWNAYILSvrp---rdiVVADCNIDQ 767  Hymenolepis m...
QAV53952      555 RKYSHTWSAINLKp-VEFDIDSEseeNKQWLFDQYYRKVEEFSDlnHIEKKVIQMWNKELLSyg------vYVSDIQIEH 627  Dugesia japonica
QAV53953      485 RKYFYSTTGIVKCi-GDLDVDSEaedNLDWLQQMYFKRIEEFTDvnPGEKRIMQLWNSHLLDh-------kYNGDFMVPI 556  Dugesia japonica
TGZ66764      945 RVYYHTRSVQPLRa-CEFDHDSEaedAPEWLRQHYQRKVEEFTDvnQGEKQLMQLWNALLLSigp---selVVCDSQLAN 1020 Opisthorchis ...
XP_031618853  439 RTYYHSYSGLALKp-SEIDVDSEtetDPIWLQKNTVKMINDFLDvnDGEKGIMKLWNLFILKh-------tFVSDSQIPA 510  swede midge
VDQ06155      308 RVYYHTTTTQPIRa-CEIHVDSDdddAPDWLRQHYQRKVEEFSDvnQVSLFSASAFLLPTLSl--------SLCLSVFYD 378  Trichobilharz...
VDK77305      586 RVYYHTNTMQPITa-AVFDEDSEsedAPGWLREHYQRKVEEFTD--VNKRGLRNNLLLHLTNlvdyglvtpNLLRRAMTL 662  Dibothrioceph...

Feature 1                             ##### ### #########   #  ##   #  #  
5HYN_C         79 ACMLFVENYgqki----ikkNLCRNFMLHLVSMHDFNLIs--IMSIDKAVTKLREM 128  human
VDM30234      836 LLLAFVRRYgnrl----hyhHLRNNFILHLANLYDYGLLa--PSLMRKVTCAFDDL 885  Hydatigera taeniaeformis
PAA80430      628 LCSTFIDRCapdl----larGLRGNLLLHLASLTDYGLVr--PDLLYELLLRVNQL 677  Macrostomum lignano
CDS33784      768 LLMGFVKSYgvrm----nnqNLRNAFILHLTNLYDYGILs--PTSMHRCVLAFDAA 817  Hymenolepis microstoma
QAV53952      628 LVKNFIERIiekenqlkevkSMRNTFMLHLMNLIDFGVLs--SATMLQCMKRLDEA 681  Dugesia japonica
QAV53953      557 LTKSFIIQKgaei----kehNLRNNLLLHLVNLVEFGVLs--QKQLIEVIGILDQM 606  Dugesia japonica
TGZ66764     1021 LAACFVQRYasai----hrrHLRNNLILHFANLVDYGLLs--PGQLRQLVTMYDKL 1070 Opisthorchis felineus
XP_031618853  511 AVITFIETYgesi----iknHLYRNCIIHLSNLFDYGLIs--AKDHLKASRKLHAV 560  swede midge
VDQ06155      379 RQLMFYNYLgnsn----tesFRQKLAAFHPADPVLYFHDl--CSLSLFLVSSLHVI 428  Trichobilharzia regenti
VDK77305      663 FDSLLVESQks-------eePYKQDAEGQLLRENKSRLVspdAKSMGKPYVVLSQC 711  Dibothriocephalus latus

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