Conserved Protein Domain Family
betaCoV_Nsp2_HKU9-like

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cd21518: betaCoV_Nsp2_HKU9-like 
betacoronavirus non-structural protein 2 (Nsp2) similar to bat coronavirus HKU9 Nsp2, and related proteins from betacoronaviruses in the D lineage
Coronavirus non-structural proteins (Nsps) are encoded in ORF1a and ORF1b. Post infection, the genomic RNA is released into the cytoplasm of the cell and translated into two long polyproteins (pp), pp1a and pp1ab, which are then autoproteolytically cleaved by two viral proteases Nsp3 and Nsp5 into smaller subunits. Nsp2 is one of these subunits. This subgroup includes Nsp2 from Rousettus bat coronavirus HKU9 and betacoronaviruses in the nobecovirus subgenus (D lineage). It belongs to a family which includes Severe acute respiratory syndrome coronavirus (SARS-CoV) Nsp2, and Murine hepatitis virus (MHV) Nsp2 (also known as p65). The function of Nsp2 remains unclear. SARS-CoV Nsp2, rather than playing a role in viral replication, may be involved in altering the host cell environment; deletion of Nsp2 from the SARS-CoV genome results in only a modest reduction in viral titers. It has been shown to interact with two host proteins, prohibitin 1 (PHB1) and PHB2, which have been implicated in cellular functions, including cell-cycle progression, cell migration, cellular differentiation, apoptosis, and mitochondrial biogenesis. MHV Nsp2/p65, different from SARS-CoV Nsp2, may play an important role in the viral life cycle.
Statistics
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PSSM-Id: 394869
Aligned: 10 rows
Threshold Bit Score: 966.539
Created: 8-Apr-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structure of SARS-CoV-2 Nsp2 with bound zinc ion

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                      
P0C6T6     176 DVYLSDQYGFDNNGILVEPVMKLLGVIKSDFTLEQLLAALGKYRTEDGYDLPDGYVKVAIKVGRKAVPVLKQSIFTVVGV 255  Rousettus bat co...
ABN10934   176 DVYLSDQYGFDNNGVLVKPVQDLLGDIRPDFTLEELTLCLSDYRTDDGYDLLGGYVKVAVKVVRKPVPVVKQTIFTVQGV 255  Bat coronavirus ...
ADM33557   176 NAYMSDQYGFDNNGNLVKPVLELLGGIKPDLTLEKLTLALSEYRNSDGYDLPGGFVRVAVSVIRKPVPVVKQTIFTVQGV 255  Bat coronavirus ...
ADM33581   176 NAYMSDQYGFDNNGVLVKPVQDLLGDIKPDLTLEKLTLALSDYRKDDGYDLPGGFVKIAVTVIRKPVAVVKQTIFTVQGV 255  Bat coronavirus ...
AVP25405   176 NVYMSDQYGFDNNGILVEPVKELLGDIKPDLTLEQLTLALSEYRQDEGYDLPGGFVKVAVKVIRKPVPVAKQTIFTVQGV 255  Rousettus bat co...
QDF43839   176 NVFLSDQYGFDNNGTLVEPVKELLGAIKSDFTLEQLLAALSAYSKDDGYDLPGGFVKIAVTVIRKPLPVVRQSIFTVQGV 255  Coronavirus BtRt...
AOG30811   176 NTFLTDQYGFDADGVLAAPIKEVLGDKGAGMSLVELTKFLGKYRTADGYELPSGIVKVAVKVVRKNLPVSKQSIFTVLGV 255  Rousettus bat co...
AWV67046   174 GVVYTDQYGFDADGVLVKPIMDLLGPIKSGYTLANLLDDLAPYKCDDGYELPTGTVCIAFDVVRKNVPVVKQNIFTVQGV 253  Bat coronavirus
AWV67062   185 GVVYTDQYGFDADGVLAKPIVDLLGPFKSGYTLANLLDDLAPHKCDDGYELPTGTVCIAFEVVRKDVPVVKQNIFTVQGV 264  Bat coronavirus
AWV67038   175 GVFYTDQYGFDADGVLVKPIMDLLGPLKSGYTLANLLDDLAPYKCDDGYELPTGTVCVAFEVVRKNVPAAKQNIFTVQGV 254  Bat coronavirus
Feature 1                                                              #  #               # #  
P0C6T6     256 TEQLVPGYYYPFSTssvVEHTKPTRGGPVGKTVEAVMLSLYGTNNYNPATPVARLKCSYCDYYGWTPLKDIgTVNCLCGA 335  Rousettus bat co...
ABN10934   256 IEQCVEGYYYPFPPmsaVKHTKPRSDKPLGKTVDSIMLSLYGTSGYNPATPVVRLRCSHCDFYGWVPLKDMgTVSCSCSA 335  Bat coronavirus ...
ADM33557   256 VEQHVEGFYYPYSTmsvVKHTKPRSDKPLGKTVESIMLSLYGTSGYSPATPVVRLRCSYCDFYGWVPPRDMgTVVCSCGA 335  Bat coronavirus ...
ADM33581   256 VEQHVEGYYYPYAPlgvVKQTKPAAGGPIGKTVEAIMLSLYGTSGYKPATPVARLKCSYCDHFGWTPLKDMgTVVCLCGA 335  Bat coronavirus ...
AVP25405   256 VEQHVEGYYYPYSPmsaVKHTKPRSDKPVGKTVDAIMLSLYGTRCYNPATPVVRLRCGYCDFYGWVPPRDMgTVLCSCGA 335  Rousettus bat co...
QDF43839   256 IEHLVEGYYYPLTTgsvVKHTKPRPNVPLSNTVESIMLSLYGTSGYSPATPVVRLNCNYCYFYGWVPLRDMgSVVCSCKA 335  Coronavirus BtRt...
AOG30811   256 TERVVDGFYYPYSTnsvVSYTKPRAGATVGNTVQSVMLSVYGTEAYNPVTPVVRLRCSSCDFYGWVPVKDLgCVTCSCAA 335  Rousettus bat co...
AWV67046   254 LNQLVPGIYYPYSSgskVVTTKPARDSPAAKTVSSIMLSLYGTSQYAPVTPVARIACTTCGFLGWLPLKDAgTVVCGCNA 333  Bat coronavirus
AWV67062   265 LNQLVPGIYYPYSSgskVVTTKPARDSPAAKTVSSIMLSLYGTAQYAPVTPVARIACPTCGFLGWLPLKDAgTVVCGCNA 344  Bat coronavirus
AWV67038   255 LNQLVPGIYYPYSSgskVVTTKPARDSPAAKTVSSIMLSLYGTAQYAPVTPVARIACPTCGFLGWLPLKDAgTVVCGCNA 334  Bat coronavirus
Feature 1                                                                                      
P0C6T6     336 EFqltSSCVDAESAGVIKPGCVMLLDKSPGMRLIPGNRTYVSFGGAIWSPIGKVNGVTVWVPRAYSIVAGeHSGAVGSGD 415  Rousettus bat co...
ABN10934   336 VHqltSSCIDAESAGAIKPGCVMLLDKSPGMRVIPGNRTYVAFGGAIWSPIGKVGDVTVWVPRAYSVIAGdHSGAVGSCD 415  Bat coronavirus ...
ADM33557   336 EFqltSACVDAESAGAIKPGCVMLLDRSPGMRLIPGNRIYVAFGGAIWSPIGTVNGVSVWVPRSYSVVAGdHSGAVGSCD 415  Bat coronavirus ...
ADM33581   336 EYqltSSCVDAESAGLIKPGCVMLLDKSPGMRVIPGNRTYVAFGGAIWSPIGKVNDVTVWVPRAYSIVAGdHSGAVGSGA 415  Bat coronavirus ...
AVP25405   336 EYqltSNCVDAESAGAIRPGCVMLLDKSPGMRVIPGNRTYVAFGGCIWSPIGSVNGVTVWVPRSYSVIAGdHSGAVGSCD 415  Rousettus bat co...
QDF43839   336 EHqltSSCIDAESAGVVKPGCVLLLDKSPGMRIIPGNRTYVAFGGAIWSPIGVVNNVTVWVPRIYSDLTDnHTGAVGTGN 415  Coronavirus BtRt...
AOG30811   336 VHqitSSCIDAESAGLIKQGAVMLVDRSPSMRVVPGNRLYVAFGGAIWSPIGKVNGVQVWVPRAYSCVAGdHSGAVGSGD 415  Rousettus bat co...
AWV67046   334 TYnmtSTAVQAESSGFIRQGAVLCLEKGEAMRLVPGGRTYLAFGGAIWSPIGKDKDVTVWVPRTYSVLCNeHSGVVGTGD 413  Bat coronavirus
AWV67062   345 TYnmtSTAVQAESSGFIRQGAVLCLEKGEAMRLVPGGRTYLAFGGAIWSPIGKDKDVTVWVPRTYSVLCNeHSGVVGTGD 424  Bat coronavirus
AWV67038   335 TYnmtSTAVQAESSGFIRQGAVLCLEKGEAMRLIPGGRTYLAFGGAIWSPIGKDKDVTVWVPRTYSVLCNeHSGVVGTGD 414  Bat coronavirus
Feature 1                                                                                      
P0C6T6     416 TVAINKELVEYLIEGIRVDADTLdnptcATFIANLDCDTKAPVVHTVESLQGLCLANKIm-----LGDKPLPTDEFHPFI 490  Rousettus bat co...
ABN10934   416 VTAMNKELMAFIIEGFKIDEDTLekpscAAFIANIQCDEKSPVVHTVDSITKMCLDNKVv-----LGEHPLPDDEFHPAI 490  Bat coronavirus ...
ADM33557   416 VTTMNKEIMAFIIEGFKIDEDTLekpscATFIANMQCDEKTPVVHTVETIVQLCLDNKVv-----LGNHPLPDDEFHPVI 490  Bat coronavirus ...
ADM33581   416 VLTINREIMAYIVEGFKIDDETLdnpacASFIANLECDAKTPTVHTVESLKDLCLANKIm-----LGDKPLPTDEFHPVV 490  Bat coronavirus ...
AVP25405   416 VTIMNRELIAYIIEGFKIDEDTLdkpscAAFIANMQCDEKTPVVHTVDTITQLCLNNKVv-----LGDHPLPDDEFHPAI 490  Rousettus bat co...
QDF43839   416 VKLLNSEIKAFLVEGFKIDEDTLekpscVSFVANLQCDDKPIVYTVESVKQLCIDNNVT------VGVHPIPEDEFHPAL 489  Coronavirus BtRt...
AOG30811   416 VNTINKEIMSLIIDGVRIDDEVLeqpscGVLIANLEDPSAAPRVHTVDSLRQLCVDNNVm-----LGDTPLPKDEFHPGI 490  Rousettus bat co...
AWV67046   414 VRAYNEELVGLLSEGFFIDEEAL-----AKESVSCMIADALPEDHDAVTLNVDLVKQYLfdanvpLGQRPVPSDPYHPAI 488  Bat coronavirus
AWV67062   425 VRAYNEELVSLLSEGFFIDEEAL-----AKESVSCMIADALPEDHDAVTLNVDLVKQYLfdanvpLGQRPVPSDPYHPAI 499  Bat coronavirus
AWV67038   415 VRAYNEELVSLLSEGFFIDEEAL-----AKESVSCMIADALPEDHDAVTLNVDLVKQYLfdanvpLGQRPVPSDPYHPAI 489  Bat coronavirus
Feature 1                                                                                      
P0C6T6     491 VGLaYHVQRACWYGALASRTFEAfRDFVRTEEERFAQFFGKVCAPIngcvylaytTGRVTLFSAYQVLNTAIAKSKDAFG 570  Rousettus bat co...
ABN10934   491 VGMnYYTQRTCWYAALSSKTFAAmRDYVRREEERLRVFCGKAFTPVsaclqmayqSGRVTLVTAYQVLDTALTKTKDAFG 570  Bat coronavirus ...
ADM33557   491 VGLnYYTQRTLWYAALNSKTFAAmRDYVCREEERLRAFCGRAFIPVgaglhmayqTGKVTLTSAYHVLEAALTKTKDAFG 570  Bat coronavirus ...
ADM33581   491 VGLaFYAQRACWYGTLASTTFEAlRTFVRAEEERLAHFCGSVCAPInscvqlaykQGRVTVLSAFHVLNIAISKTKEAFG 570  Bat coronavirus ...
AVP25405   491 VGLnYYTQRACWYAALSSKTFSAmREYVRKEEERLRVFCGRAFSPVamgvqmayrSGKVTLVSAYHVLDTALTKTKDAFG 570  Rousettus bat co...
QDF43839   490 LGPvYYTQRIYWYAALASTTFTAmRTFVRKEEEKIAQFSVKMYAALssvvkiaydRGVVSLFTGYQILEAFVTKTQVLVS 569  Coronavirus BtRt...
AOG30811   491 VGLsYHFYRACWYGVLTAKSFGAfKELLQSEEVRLSHFCANIRRCLdralnwartTGNVSLLSSSLVLKALAENLLDSVK 570  Rousettus bat co...
AWV67046   489 QGVsYHVRRACTLAMRAGVAFGAvKTSFYKEVDRILVKVNFDYWQQl--------TTVNIPLRAFLVLDAMVSESAVAWG 560  Bat coronavirus
AWV67062   500 QGVsYHVRRACTLAMRAGVAFDAvKTSFYKEVGLILVKVNFDYWQQl--------ATVNIPLRAFFVLDAMVSEGAIAWG 571  Bat coronavirus
AWV67038   490 QGVsYHVRRACTLAMRAGVAFDAvKTSFYREVGRILVKVNFDYWQQl--------ATVNIPLRAFFVLDAMVSEGAIAWG 561  Bat coronavirus
Feature 1                                                                                      
P0C6T6     571 GVAAivvDMLKPILEWVLKKMsiAKGAWlpYAEGLLALFKAQFTVVKGKFQFLRASLNSKCHSLCDLLTTIMSKLLTSVK 650  Rousettus bat co...
ABN10934   571 GAAVvvsDLLKPTLDWVLTKMtlAKGVWlrYAETILALFKAQFTFVKGKFVFARDALNKSCGALRDLLSVVLSKLLTSAR 650  Bat coronavirus ...
ADM33557   571 GAAAvvvDLLKPVMDWVLNKMslAKGIWlrYAEAILALFRAQFTFIEGKFHFVRDTLNSSCGALRDLLSALLSKLLTSAR 650  Bat coronavirus ...
ADM33581   571 GAKSaiyDILKPALDWVLKKMslAKGVWlhYAEAILALFKAQFTFVKGKFQFVRGALNKTCGNLRDMLTVVVGKLLTSVK 650  Bat coronavirus ...
AVP25405   571 GASSvvrDILKPVLDWVLTKMtlVKGVWlrYAEAILALFKAQFTLVKGKFVFLCDALNKSCGALRDLLTVVFGKLLTTAK 650  Rousettus bat co...
QDF43839   570 DTLAvvaAILKPTLEWVLNKMtlVKNTWlyYAEALIALFKAQFTVVKGKFFFLKDALNKPCGALRDLLAVVLTKLLTTAK 649  Coronavirus BtRt...
AOG30811   571 NTPFlvgDLVKPVLDWIVEKMvlARDSVvsCAEAVLSLFNMQFTFAKGKFTFLKEKLNKSCVALRELLTVIVNKFATTVK 650  Rousettus bat co...
AWV67046   561 HWTSiakDFIAAFKPWLLNAFkvTTQAIvdTALAVTHFLQVKFTYINGEFSFVVARLNQSCEFLRNLFQKLLSAFKTTTK 640  Bat coronavirus
AWV67062   572 HWTSiakDLLAAFKPWLLNVFkvTTQAIvdTALALTQFLQAKFTYVNGEFAFLVTRLNQSCEFLRTLFQKLLAVFKTTTK 651  Bat coronavirus
AWV67038   562 HWTSiakDLLAAFKPWLLNVFkvTTQAIvdTALALTQFLQVKFTYINGEFSFLVARLNQSCEFLRNLFQKLLSAFKTTTK 641  Bat coronavirus
Feature 1                                                                                      
P0C6T6     651 WAGCKVDALYTGTYYYFSRKGVLTEVQLCAkrLGLLLTPKQQKMEVEVLDGDFDAPVTLTDLELEECTGVLEEVFGASDV 730  Rousettus bat co...
ABN10934   651 WAGCKVEALYTGTYHYFAKCGVLSETQVCAkvLGVLLTPRQQKMEVEVLEGTPDAPVDLTNNELEEAHGTLEEVFGYSDL 730  Bat coronavirus ...
ADM33557   651 WAGCKVEAVYTGTYHYFAKFGVVSELQIRAkaLGVLLTPRQQKMEVEVLEGKADAPVELTSLELEELHGTLEEVFGYSDL 730  Bat coronavirus ...
ADM33581   651 WAGCKVEALYTGTYYYFSQNGLLTEVQVCAkrLGLLLTPRQQKMEVEVLDGDYDAPVTLTDLELEESTGVLEEVFGASDV 730  Bat coronavirus ...
AVP25405   651 WAGCKVEAMYTGSYHYFSKCGVLTEAQVCAkvLGVLLTPKQQKMEVEVLEGTPDAPVDLTNNELEEANGTLEEVFGYSDL 730  Rousettus bat co...
QDF43839   650 WAGCKVEALYVDGYYYFSNCGLLTETQVCAksLGVLLTPKQQKMEVEVLQGAYDAPVDLTTGELEDASGTLEEVFGSSDL 729  Coronavirus BtRt...
AOG30811   651 WAGCKIDGFYNGDYHFFSAKGVLTEVQVCAktLGAMLTPRQQRMEVEVLDGKYDAPVAITVPELEELNGTLEEVFGFDDL 730  Rousettus bat co...
AWV67046   641 WAGCAVEGIYTNAHCFFSRTGMLVEKQLKAssLGFIFTPRQAKAEIEVLEGDFDVPVELCSEEVDENAGTLEEVFGASDL 720  Bat coronavirus
AWV67062   652 WAGCTVEGIYTNAHCFFSRTGMLVEKQLKAssLGFIFTPKQVKSEIEVLEGEFDVPVELCSEEVDENAGTLEEVFGASDL 731  Bat coronavirus
AWV67038   642 WAGCAVEGIYTNAHCFFSRTGMLVEKQFKAssLGFIFTPRQAKAEIEVLEGDFDVPVELCSEEVDENAGTLEEVFGASDL 721  Bat coronavirus
Feature 1                                                
P0C6T6     731 KLVKGTLVSLASKLFVRTEDGFLYRYVKSGGVLGKAFRLRGG 772  Rousettus bat coronavirus HKU9
ABN10934   731 ELVKGSLVTMASKVFVRTDDGVFYRYVRSGGVLLKAFRLRGG 772  Bat coronavirus HKU9-4
ADM33557   731 GLVKGSLVTMASKVFVRTDDGVLYRYVKSGGVLLKAFRLRGG 772  Bat coronavirus HKU9-5-1
ADM33581   731 KLVQGTLVSLASKLFVRTADGLFYRYVKSGGVLSKAFRLRGG 772  Bat coronavirus HKU9-10-2
AVP25405   731 ALVKGSLVTMASKVFVRTEEGVFYRYVKSGGVLLKAFRLRGG 772  Rousettus bat coronavirus HKU9
QDF43839   730 ALVKGSLVTMASKVFVRTEDGILYRYVREGGVLLKPFRLRGG 771  Coronavirus BtRt-BetaCoV/GX2018
AOG30811   731 TLVRGSLVALASKVFVRTDDGLLFRYVKSGGVFLKAFRLRGG 772  Rousettus bat coronavirus
AWV67046   721 QIVRGQLSVLASKLFVRTEEGLFYRYVSSGGVLLKAFRLRGG 762  Bat coronavirus
AWV67062   732 QIVRGQLSVLASKLFVRTEEGLFYRYVSSGGVLLKAFRLRGG 773  Bat coronavirus
AWV67038   722 QIVRGQLSVLASKLFVRTEEGLFYRYVSSGGVLLKAFRLRGG 763  Bat coronavirus

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