4I5J,4I5K


Conserved Protein Domain Family
PPP2R3A
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cd21506: PPP2R3A 
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serine/threonine protein phosphatase 2A regulatory subunit B" subunit alpha
Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. This group contains protein phosphatase subunit PR130 (also known as protein phosphatase 2A regulatory subunit B'' subunit alpha, PR72, or PPP2R3) that is encoded by the PPP2R3A gene. PR130 and PR72 subunits are derived from the same gene through differential splicing; they harbor specific N-terminal domains of different lengths that are encoded by alternatively spliced exons and have identical C-termini. The common C-terminus contains a two-domain elongated structure with two calcium EF-hands which mediate Ca2+-dependent changes in phosphatase activity. The PR130 subunit has been shown to interact with the LIM domain of lipoma-preferred partner (LPP) through a conserved Zn2+-finger-like motif in the N-terminus of PR130.
Links
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Statistics
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PSSM-Id: 410339
Aligned: 9 rows
Threshold Bit Score: 612.325
Created: 7-Apr-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Ca binding siteCa binding site
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: Ca binding site 1 [ion binding site], 4 residue positions
Conserved feature residue pattern:D D D DClick to see conserved feature residue pattern help
Evidence:
  • Comment:members of this family contain 2 Ca2+-binding sites
  • Structure:4I5K: Homo sapiens protein phosphatase 2 regulatory subunit B'' subunit alpha binds calcium ion
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
4I5J_A          2 WRKLLnnHHDDASKFICLLAKPNCSSLEQEDFIPLLQDVVDTHPGLTFLKDAPEFHSRYITTVIQRIFYTVNRSWsGKIT 81   human
4I5K_A          2 WRKLLnnHHDDASKFICLLAKPNCSSLEQEDFIPLLQDVVDTHPGLTFLKDAPEFHSRYITTVIQRIFYTVNRSWsGKIT 81   human
XP_001364855  791 WRKLLynCHDDASKFIHLLAKPNCSYLEQEDFIPLLQDIVDTHPGLTFLKDAPEFHSRYITTVIQRIFYTVNRSWtGKIT 870  gray short-ta...
XP_007885555  808 WRKVLqtCHDDASRFVYLLAKPSCNYLEQEDFIPLLQDIVDTHPGLTFLKDAPEFHSRYITTVIQRIFYTVNRSWsGKIT 887  elephant shark
XP_009296831  838 WRKLLhsCYDDASKFVYLLAKPGCTYLEQEDFIPLLQDIVDTHPGLTFLKDAPEFHSRYITTVIQRIFYTVNRSWtGKIN 917  zebrafish
NP_001082623  772 WRKLIqnCHDDASKFVSLLAKPGCDYLEQEDFIPLLQDIVDTHPGLTFLKEAPEFHSRYITTVIQRIFYTVNRSWsGRIT 851  African clawe...
XP_004936979  786 WRKILcsCHDDASRFAYLVAKPSCGYLEQEDFIPLLQDVVETHPGLTFLKDAPEFHSRYITTVIQRIFYTVNRSWsGKIT 865  chicken
XP_014341165  831 WRKSLytCHDDASKFVYLLTKPGCNYLEQEDFIPLLQDLVDTHPGLTFLKDAPEFHSRYITTVIQRIFYTVNRSWsGKIT 910  coelacanth
Q06190        787 WRKLLnnHHDDASKFICLLAKPNCSSLEQEDFIPLLQDVVDTHPGLTFLKDAPEFHSRYITTVIQRIFYTVNRSWsGKIT 866  human

Feature 1                                                      # # #      #                       
4I5J_A         82 STEIRKSNFLQTLALLEEEEDINQITDYFSYEHFYVIYCKFWE-LDTDHDLYisQADLSRYNDQasSSRIIERIFSGAVT 160  human
4I5K_A         82 STEIRKSNFLQTLALLEEEEDINQITDYFSYEHFYVIYCKFWE-LDTDHDLYisQADLSRYNDQasSSRIIERIFSGAVT 160  human
XP_001364855  871 LTELRKSNFLQTLALLEEEEDINQITDYFSYEHFYVIYCKFWE-LDSDHDLYinQTDLSRYNDQasSSRIIERIFSGAVT 949  gray short-ta...
XP_007885555  888 LTELRKSNFLQTLALLEEEDDINQITDYFSYEHFYVIYCKFWE-LDTDHDLFvdQKDLARHNDHaiSNRIIERIFSGAVT 966  elephant shark
XP_009296831  918 MTELRRSNFLQTLALLEEEDDINQITDYFSYEHFYVIYCKFWE-LDSDHDLFidPKDLARYNDHasSSRIIERLFSGAVT 996  zebrafish
NP_001082623  852 LIEMKRSNFLQTLALLEEEDDINQVTDYFSYEHFLIVIYCKFWeLDTDHDLYidHKDLARYNDHasSKRIIERIFSGAVT 931  African clawe...
XP_004936979  866 LTELRKSNFLQTLALLEEEDDINQITDYFSYEHFYVIYCKFWE-LDTDHDLYisQKDLARYSDQalSSRIIERIFSGAVV 944  chicken
XP_014341165  911 LTELRKSNFLQTLALLEEEDDINQITDYFSYEHFYVIYCKFWE-LDTDHDLYidQKDLARYNDHasSNRIIERIFSGAVT 989  coelacanth
Q06190        867 STEIRKSNFLQTLALLEEEEDINQITDYFSYEHFYVIYCKFWE-LDTDHDLYisQADLSRYNDQasSSRIIERIFSGAVT 945  human

Feature 1                                                                                         
4I5J_A        161 RgktiqkeGRMSYADFVWFLISEEDKRNpTSIEYWFRCMDVDGDGVLSMYELEYFYEEQCERMEamgIEPLPFHDLLCQM 240  human
4I5K_A        161 RgktiqkeGRMSYADFVWFLISEEDKRNpTSIEYWFRCMDVDGDGVLSMYELEYFYEEQCERMEamgIEPLPFHDLLCQM 240  human
XP_001364855  950 RgnvvqkeGRMSYADFVWFLISEEDKRNlTSIEYWFRCMDLDGDGVLSMYELEYFYEEQCERMEamgIEPLPFHDLLCQM 1029 gray short-ta...
XP_007885555  967 RgnsvqkdGRMSYADFVWFLVSEEDKKNaTSMEYWFRAMDIDGDGVLSMYELEYFYEEQCERMEgmgIEPLPFHDLLCQM 1046 elephant shark
XP_009296831  997 RgnsvqreGRMSYAEFVWFLISEEDKKNpTSIEYWFRCMDMDGDGVLSMFELEYLYEEQCERMEgmgIEPLPFQDLLCQM 1076 zebrafish
NP_001082623  932 RgnavqreGRMSYAEFVWFLISEEDKKNpNQHEYWFRCMDLDGDGVLSMYELEFFYEEQCEKMEamgIEPLPFQDLLCQL 1011 African clawe...
XP_004936979  945 RgnevqkeGRMSYADFVWLLISEEDKRNaTSIEYWFRCMDLDGDGVLSMYELEYFYEEQCERMEvmgIEPLPFQDLLCQM 1024 chicken
XP_014341165  990 RgnsvqkeGRMSYADFVWFLISEEDKKNpTSIEYWFRAMDLDGDGMLSMYELEFFYEEQCERMEamgIEPLPFHDLLCQM 1069 coelacanth
Q06190        946 RgktiqkeGRMSYADFVWFLISEEDKRNpTSIEYWFRCMDVDGDGVLSMYELEYFYEEQCERMEamgIEPLPFHDLLCQM 1025 human

Feature 1                                                      
4I5J_A        241 LDLVKPAvdgKITLRDLKRCRMAHIFYDTFFNLEKYLDHEQRDPF 285  human
4I5K_A        241 LDLVKPAvdgKITLRDLKRCRMAHIFYDTFFNLEKYLDHEQRDPF 285  human
XP_001364855 1030 LDLVKPEldgKITLRDLKRCRMAHIFYDTFFNLEKYLDHEQRDPF 1074 gray short-tailed opossum
XP_007885555 1047 LDLVKPEcegKITLRDLKRCRMAHIFYDTCFNLEKYLDHEQRDPF 1091 elephant shark
XP_009296831 1077 LDLVKPEcpsKITLRDLKRCRMAHIFYDTFFNLEKYLDHEQRDPF 1121 zebrafish
NP_001082623 1012 LDLVKPEaegQITLRDLKRCKMAHIFYDTCFNLEKYLDHEQRDPF 1056 African clawed frog
XP_004936979 1025 LDLVKPEregRVTLRDLKRCRMAHVFYNTFFNLEKYLDSEQRDPF 1069 chicken
XP_014341165 1070 LDLVKPEydgKITLRDLKRCRMAHIFYDTFFNLEKYLDHEQRDPF 1114 coelacanth
Q06190       1026 LDLVKPAvdgKITLRDLKRCRMAHIFYDTFFNLEKYLDHEQRDPF 1070 human

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