4MEW,4I5J,4I5K


Conserved Protein Domain Family
PPP2R3A_B-like

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cd21504: PPP2R3A_B-like 
Click on image for an interactive view with Cn3D
serine/threonine protein phosphatase 2A regulatory subunit B" alpha and beta subunits, and similar proteins
Heterotrimeric serine/threonine protein phosphatase 2A (PP2A) consists of scaffolding (A), catalytic (C), and variable (B, B', and B") subunits. The variable subunits dictate subcellular localization and substrate specificity of the PP2A holoenzyme. These B-family regulatory subunits play various roles including regulation of cytoskeletal assembly, neuronal differentiation, mitogen-activated protein kinase signaling, and apoptosis. This subfamily includes protein phosphatase 2A regulatory subunit B'' subunits alpha and beta, encoded by PPP2R3A and PPP2R3B. It also includes subunit delta encoded by PPP2R3D in mouse. They contain two-domain elongated structures with two calcium EF-hands which mediate Ca2+-dependent changes in phosphatase activity.
Statistics
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PSSM-Id: 410337
Aligned: 44 rows
Threshold Bit Score: 378.814
Created: 2-Apr-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
Ca binding siteCa binding site
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1: Ca binding site 1 [ion binding site], 4 residue positions
Conserved feature residue pattern:D D D [NED]Click to see conserved feature residue pattern help
Evidence:
  • Comment:members of this family contain 2 Ca2+-binding sites
  • Structure:4MEW: Homo sapiens serine threonine protein phosphatase 2A regulatory subunit B" subunit beta binds calcium ion
    View structure with Cn3D
  • Structure:4I5K: Homo sapiens protein phosphatase 2 regulatory subunit B'' subunit alpha binds calcium ion
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                         
4MEW_A         76 WRKILqnc-hdDAAKFVHLLxs--------------------------pGCNYLVQEDFVPFLQDVVNTHpGLSFLKeas 128  human
XP_001423306  214 WNQHLaq--kePKNRCFQIFkk--------------------------pKNDYIEFEDFKPFMKILLQEHpGLEFLQatp 265  Paramecium te...
XP_002997335  332 WMREMap--cdSVERFFRVVkq--------------------------pKNDFIERDDFAPFLHELLKYHpGLEFLGgtp 383  Phytophthora ...
XP_011400271  148 WLDRAgfwgldGPGRAMEILra--------------------------pGSAGVTPADLKPVLAGILISHpGLEFLAesp 201  Auxenochlorel...
XP_001438471  214 WNQQLaq--kePKQRCFHILkk--------------------------pKNDFIQFDDFKPFMKILLEQHpGLEFLQatp 265  Paramecium te...
OSX74961      767 YEAECag--vsRDDRMFRALrg-------------------------daDRDYVVASDFKAVLDSLLACHpGLNFLNatp 819  Porphyra umbi...
XP_641497     432 WKTYIyg--kdAEDLLFNILkk-------------------------seDSNFLFYEDFFLFSKTLIDFHpGLEFLSntp 484  Dictyostelium...
XP_002787503  255 WRGLGlel-gkAYENFFNIVrk--------------------------dTSDCIVKNDFREFVWVLLDTHpGLEFLQdtp 307  Perkinsus mar...
XP_011776943  365 YYNVFgp--lsINRRLFELLrn-------------------------dsRSEHLTLQNLKDATRYLVDSHpGLEFLKq-p 416  Trypanosoma b...
XP_011775201  632 FESSLrg--rsIVRRVFELFllssstgkhncrsavgagsncastphsasPRSYLLPEDFRGYLRILLDHHpGLALLKqtp 709  Trypanosoma b...
Feature 1                                                                                  # # #  
4MEW_A        129 EFHSRYITTVIQRIFYAVNrswsgriTCAELRRs--sFLQNVALLEEeaDINQLtefFSYEHFYVIYCKFWElDTDHDll 206  human
XP_001423306  266 EFQERYADTVIHRIFYHLCrkdngkiTWRDFKQs--nLFDILDLVAKedDINKIrqyFSYEHFYVIYCKFWElDGDHDfh 343  Paramecium te...
XP_002997335  384 EFQEKYALTVVVRIFYSVDrdssgqlTLRKLRRs--nLISAFNAVDEeeDINKVnsyFSYEHFYVLYCKFWElDTDHDfl 461  Phytophthora ...
XP_011400271  202 EFQERYAETVIHRIFYSLNrsgtgvlSQRELRRg--dLLAALGEVDAqdDINRVaryFSYEHFYVIYCKFWDlDTDHDfl 279  Auxenochlorel...
XP_001438471  266 EFQERYADTVIHRIFFHLCrkdnnkiTWRDFKSs--nLFDILDILGKedDINKIrqyFSYEHFYVIYCKFWElDGDHDfh 343  Paramecium te...
OSX74961      820 EFQQRYAETVVERIFYGCArthagrlTLRDVRTa--hLLDTLLLVDEedDINRErryFSYEHFYVLYCRFWElDSDHDll 897  Porphyra umbi...
XP_641497     485 EFQDRYQETIIIRIFYGTCrnr-griTAKDLKTn--nFIRSLSLLDAepDINKHleyFSYEHFYVIYCKFWElDMDHDlf 561  Dictyostelium...
XP_002787503  308 EFQDRYTDTVLCRIFYSCDskqlgriSLRDIKRsrpsLVDTWLELDQceDINKIrayFSYEHFYVLYCKFWElDEDHDfl 387  Perkinsus mar...
XP_011776943  417 EFQEYYCRTVAIRIVYSLErqqcgfiSWYDFDRs--dLPEVMQEVDEk-DVNVVlqyFSYEHFYVLYCKFWElDTDRDql 493  Trypanosoma b...
XP_011775201  710 DVQNRYMETVIYRIFYDLDrfnrgriTYAEMEDs--aLIDSLRQVDVadDINSVfhyFSYEHFYVLYCRFWElDTDRDml 787  Trypanosoma b...
Feature 1             #                                                                           
4MEW_A        207 idADDLARHndh-alSTKXIDRIFSGavtrgrkv------qkegkisYADFVWFLISEEDKktptSIEYWFRCXDLDGDG 279  human
XP_001423306  344 isKEDFSRYssh-glSRKVVDRIFDQiprrfrs-------eidqkmsYEDFVYFIQCEEDKttiqSIEYWFKVIDLDSNG 415  Paramecium te...
XP_002997335  462 lsPDDLVRYggh-alTRIIVDRIFERgrrpfarvqt-ltseekkkmsYEDFIYFMLSEEDKanpvSIRYWFELIDTNEDG 539  Phytophthora ...
XP_011400271  280 lsRDDLLRYgnh-alTFRITERIFSQaarpfst-------gnpaqmgYEDFIWFILSEEDKttdtSLEYWFRCCDLDGDE 351  Auxenochlorel...
XP_001438471  344 isKEDFSLVklsieyLIRFLRRFRSQidq---------------kmsYEDFIYFILCEEDKttiqSIEYWFKIIDLDDNG 408  Paramecium te...
OSX74961      898 idRADLQRYggh-alSYRIVDRLFSGaarpldaarestngnggglmgYTDFVWFCLSEEDKtsdtAIDFWFRCVDLDGDG 976  Porphyra umbi...
XP_641497     562 idSNDLAKYgsc-slTPLIIERIIANsiftkplf------girnkisYQDFVWFILSEEDKtsetSIEFWFSCCDLDCDG 634  Dictyostelium...
XP_002787503  388 ldKDDLLKYdgh-afSRKAIDRIFSEipakfis-------gipgkmgYEDFCWFLISDEDKttdaSLEYFFKLVDLDGDG 459  Perkinsus mar...
XP_011776943  494 vgFDDMCKYgqg-aiCPSVIKRIVEGagrplks-------gkpgkldFEDFVYFCLSEEDKnsrsAVYYWFKVLDVDGDG 565  Trypanosoma b...
XP_011775201  788 lsRQDFVKYtpdgvmNPIIVDRIFNGlgrrsks-------avkdrinYEEFVWFCLSEEDKttptAVRYWFSILDLDCDG 860  Trypanosoma b...
Feature 1                                                                                         
4MEW_A        280 ALSxFELEYFYEEQCRRLDsxai---ealpFQDCLCQXLDLVKPrte----gkiTLQDLKRCk---lANVFFDTFFNIEK 349  human
XP_001423306  416 IITgFEMDYFYEELKQRMDclnh---epilFQDFVCQMVDLLHPdnd----ilfKMNHFKQNls--vCGVFFNFLTNLNK 486  Paramecium te...
XP_002997335  540 VLRaDEMRVFYRHQIHRMEclgh---evvpFEDILCQMSDLLHPeke----gefYHKDFIRAdkirvSGVFFNVLFNLSK 612  Phytophthora ...
XP_011400271  352 HLHsSELYYFYEEQLHRMEclsq---esvsYFDVMGQLHDMLNPens----tyyTLGDLKRNra--mAGTLFNVLFNLNK 422  Auxenochlorel...
XP_001438471  409 IITgFEMDYFYEELKQRMDylnh---epilFHDFVCQMVDLLHPend----ilfKLSHFKQNlt--vCGVFFNFLTNLNK 479  Paramecium te...
OSX74961      977 VVTlFDCEYFYKEQLRRMEnlgh---epvsVEDILCQLLDMIRPsvrp---pqiRRRDLKSCr---lAPAFFNVLFNLNK 1047 Porphyra umbi...
XP_641497     635 FLSlYEMDTFYKEQKQRLDylnl---dppvFKDLLCQILDMIKPeai----ekiTLLDLKSSk---mAGYLFNVLFNINK 704  Dictyostelium...
XP_002787503  460 VIRdHEMAYFYLEQVQRLEclhq---eavrFQDILCQMNDLILPeme----gqfELEDFKRTrk--iSGIFFSILLSLNK 530  Perkinsus mar...
XP_011776943  566 ILSgYELYEFFQENQQRFLeyfecpesdlsYPDMMCQMMDMLGFshvseekfglKLSDLHSCa---tPANFFNMVFNAHK 642  Trypanosoma b...
XP_011775201  861 VLSlYELQRFYDETRRIILehvpe--ggipFEDAVCQIFDMLGVtvs----cgiTLHDLLSNse--aAGAALNMLTNVVR 932  Trypanosoma b...
Feature 1          
4MEW_A        350 Y 350  human
XP_001423306  487 L 487  Paramecium tetraurelia strain d4-2
XP_002997335  613 F 613  Phytophthora infestans T30-4
XP_011400271  423 F 423  Auxenochlorella protothecoides
XP_001438471  480 L 480  Paramecium tetraurelia strain d4-2
OSX74961     1048 F 1048 Porphyra umbilicalis
XP_641497     705 F 705  Dictyostelium discoideum AX4
XP_002787503  531 F 531  Perkinsus marinus ATCC 50983
XP_011776943  643 F 643  Trypanosoma brucei gambiense DAL972
XP_011775201  933 L 933  Trypanosoma brucei gambiense DAL972

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