Conserved Protein Domain Family
LPS_wlbK_C-like

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cd21469: LPS_wlbK_C-like 
C-terminal domain of Bordetella wlbK gene product involved in bacterial polysaccharide synthesis, and similar domains
This model includes the C-terminal domain of the gene wlbJ (also known as bplJ, bplK, wlbjK) product protein, one of 12 genes that is involved in liposaccharide (LPS) synthesis. The liposaccharides (LPS) of Bordetella species are pyrogenic, mitogenic, and toxic, and can activate and induce tumor necrosis factor production in macrophages, similar to endotoxins from other gram-negative bacteria. Also, while the family Enterobacteriaceae expresses smooth-type LPS, the Bordetella LPS molecules differ in chemical structure; B. bronchiseptica and B. parapertussis synthesize a long-chain polysaccharide consisting of a homopolymer of 2,3-dideoxy-2,3-diN-acetylgalactosaminuronic acid (2,3-diNAcGalA), known as O antigen, whereas B. pertussis does not and is therefore more similar to rough-type LPS. This substantial structural difference between the LPS molecules of the three main pathogenic bordetellae likely confers quite different surface properties on the different species. Gene characterization studies show that wlbJ and wlbK are two apparently separate genes in B. pertussis, but are fused into a single open reading frame in B. bronchiseptica and B. parapertussishu. Studies show that mutations in wlbJK do not affect LPS biosynthesis but their function remains unclear.
Statistics
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PSSM-Id: 410576
Aligned: 17 rows
Threshold Bit Score: 145.653
Created: 27-Mar-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O87996       266 AVLTPASTAAADETIQSaqagedmppvd------eigvianngdHSTAYRVQLLLDMYAQIRDMPWWQWAFGLGLGQLNL 339 Bordetella bron...
AMG38138     348 AAAAPAAEAAAPTPAVTdiva-------------------hggdVSSAIRSKILYEMYEKARAMPWWQWLTGMGVGQLNI 408 Achromobacter x...
EGP46648     210 FAAGWAILTAALIGAMHyegmqtrampqltvtqgeltvaqtpgdASTDYRRTMVIDMLHQARAMPWWQWITGMGAGQLNV 289 Achromobacter i...
KCV35895     278 AVWHDTANFDAYKHATTaakppeg-------------vvaeggdFSSAIRVSLLLEMAEVARQLPWWQFLVGMGAGQLNL 344 Bordetella bron...
CKI24290     305 APPPGAGTHVAPVPLPEthhapppapta------nvsikaqdgdESSAFRARLTMDMVAEWRAMPWWQWLTGLGAGQLNL 378 Achromobacter x...
SHS02253     268 AVLTPASTAAADETIQSaqagedmppvd------eigvianngdHSTAYRVQLLLDMYAQIRDMPWWQWAFGLGLGQLNL 341 Mycobacteroides...
OZI15787     229 LALAWAAVTGAGLLWQQyggmtlralpqitlndgewelvasqgdRSTGSRKILLMDMIGQARDMPWWQWLAGMGAGQLNV 308 Bordetella geno...
SUV70459     283 APAVGLAAEAAPLPAPSlapsasvrppnes-qtmplqitlqngdGSSATRLQLLAEMYVQARHMPWWQWIAGKGVGQLNL 361 Bordetella avium
WP_115999579 267 QALEFLANTEALEAIVSsg-----------------------nmFSVAIRAYALSEMFEVVSKFSFLNWLFGIGFGNINI 323 Thalassotalea e...
WP_119977548 243 RAWHFLANTQELKSVVEsg-----------------------slESIAVRAYALSEMIKIVNDFGLLDFMFGVGFGIINI 299 Shewanella algi...
O87996       340 MWPAt----dAQWASPHFFWlEMFFHLGLLWVAFLGWLLVRSNstGRICLITaaiag------mapssMIYLQPFWFLVG 409 Bordetella bron...
AMG38138     409 TWPLd----nWPWASPHFFWlEMFFFFGLPWIAFVGWLLWRADgyGRLALIVafaag------iapssLVYFQPFWFLLG 478 Achromobacter x...
EGP46648     290 TWPVpg--avAPWASPHLFWlEMTFYLGLAWPLALLWLLWRSDwrGRTCLVVagiag------lapssMVYLQPFWFLLG 361 Achromobacter i...
KCV35895     345 TWPLt----gSPWASPHFFWlEMLFYVGIAWAAFLLWLFWRLNwrGRIALLCcglag------mapssMVYFQPFWFFAG 414 Bordetella bron...
CKI24290     379 IWPGn----kAPWASPHFFWlEMFFHVGLGWFLLLGWLMWRLDwrGRISLLVagiag------lapssMVYFQPFWIFLG 448 Achromobacter x...
SHS02253     342 MWPAt----dAQWASPHFFWlEMFFHLGLLWVAFLGWLLVRSDstGRICLITaaiag------mapssMIYLQPFWFLVG 411 Mycobacteroides...
OZI15787     309 LWPTre--glVPWGSPHLFWlEMLFYVGVAWPLFLLWLFWRLDwiGRTCLLVigiag------iapssMVYFQPFWFLLG 380 Bordetella geno...
SUV70459     362 TWPDt----gAAWASPHMFWlEMLFYFGIGWLLLLGYLFLRLDnlGRICLVSagiag------capssIIYLQPFWLFLG 431 Bordetella avium
WP_115999579 324 SFVNnewgglIEYFAPHLFYlEMLIYAGFSYYVFYFYVMTILA--GRIPWRStlialpslgaivaissAVYFLPLYFFFA 401 Thalassotalea e...
WP_119977548 300 SFYNevwmktVSHFPPHFFYmEMLIYSGLSFFIFYFLQFKILS--GRFALKYvlilspsllsiisvssAVYFTPYYFFLA 377 Shewanella algi...
O87996       410 VCVAVLPQK 418 Bordetella bronchiseptica
AMG38138     479 VVLATLPSR 487 Achromobacter xylosoxidans
EGP46648     362 WLFASMPGT 370 Achromobacter insuavis AXX-A
KCV35895     415 ILAASIPPR 423 Bordetella bronchiseptica 00-P-2730
CKI24290     449 VLAATLPTK 457 Achromobacter xylosoxidans
SHS02253     412 VCVAVLPQK 420 Mycobacteroides abscessus subsp. abscessus
OZI15787     381 AMLAQLPRP 389 Bordetella genomosp. 7
SUV70459     432 VLMAQLPRR 440 Bordetella avium
WP_115999579 402 VLTFWEYEQ 410 Thalassotalea euphylliae
WP_119977548 378 LIVYLSTVN 386 Shewanella algidipiscicola
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