Conserved Protein Domain Family
LPS_wlbK_N-like

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cd21468: LPS_wlbK_N-like 
N-terminal domain of Bordetella wlbK gene product involved in bacterial polysaccharide synthesis, and similar domains
This model includes the N-terminal domain of the gene wlbJ (also known as bplJ, bplK, wlbjK) product protein, one of 12 genes that is involved in liposaccharide (LPS) synthesis. The liposaccharides (LPS) of Bordetella species are pyrogenic, mitogenic, and toxic, and can activate and induce tumor necrosis factor production in macrophages, similar to endotoxins from other gram-negative bacteria. Also, while the family Enterobacteriaceae expresses smooth-type LPS, the Bordetella LPS molecules differ in chemical structure; B. bronchiseptica and B. parapertussis synthesize a long-chain polysaccharide consisting of a homopolymer of 2,3-dideoxy-2,3-diN-acetylgalactosaminuronic acid (2,3-diNAcGalA), known as O antigen, whereas B. pertussis does not and is therefore more similar to rough-type LPS. This substantial structural difference between the LPS molecules of the three main pathogenic bordetellae likely confers quite different surface properties on the different species. Gene characterization studies show that wlbJ and wlbK are two apparently separate genes in B. pertussis, but are fused into a single open reading frame in B. bronchiseptica and B. parapertussishu. Studies show that mutations in wlbJK do not affect LPS biosynthesis but their function remains unclear.
Statistics
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PSSM-Id: 410575
Aligned: 12 rows
Threshold Bit Score: 187.957
Created: 27-Mar-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O87996    66 ALTRWLAATAAVLLIQLLWVEHTDRYlrflaflltgvcYTVLADALVRRRVDFAEGLYPIVLYWLITAAMPIYDAWTGsg 145 Bordetella bronchis...
1589230   33 ALTRWLAATAAVLLIQLLWVEHTDRYlrflaflltgvcYTVLADALVRRRVDFAEGLYPIVLYWLITAAIPIYDAWTGsg 112 Bordetella pertussis
CAP40518  67 RALPAAVAVMLLVCVQAAWADNQPRYaqyavilaislsYALLGEHLARQGNAYLRWLPWLVALWLLMALVPWFDLLTHse 146 Bordetella petrii
CAA62253  33 ALTRWLAATAAVLLIQLLWVEHTDRYlrflaflltgvcYTVLADALVRRRVDFAEGLYPIVLYWLITAAIPIYDAWTGsg 112 Bordetella pertussis
EGP46648  48 PHWKLVAVAAILILAQAIYASQAQRYlqfsvilmigmaHLLLAQQLAARDIDLTPMLRGLVALWLILAWFPVFDAWTHsg 127 Achromobacter insua...
KCV35895  62 RLLVPILLALALTAAQWLWADHMGRYyayavmmavgcaHALLGEMLARKMPQALDWLLPLAAMWFIVAFFPAYDVLTGss 141 Bordetella bronchis...
KDS80790  68 ALTRWLAATAAVLLIQLLWVEHTDRYlrflaflltgvcYTVLADALVRRRVDFAEGLYPIVLYWLITAAMPIYDAWTGsg 147 Bordetella bronchis...
CKI24290  63 RLKLPVLILVLLLALQSLWVVADDRYtrytiylligaaSAILGETIARRPKPFLFLFPGLLAYWFITAYFPAFDTWTEaq 142 Achromobacter xylos...
AMG38138  66 RSRYLIVSMVAMVAASSLWMIDSGRYlnyalffaigalYMTLGETMVRRGVAFERWFYPLVLYWFLTAIFPVFDTWTNat 145 Achromobacter xylos...
SHS02253  68 ALTRWLAATAAVLLIQLLWVEHTDRYlrflaflltgvcYTVLADALVRRRVDFAEGLYPIVLYWLITAAMPIYDAWTGsg 147 Mycobacteroides abs...
OZI15787  67 RVMPAAIAVLLLICAQALWAHSFPRYvqyavifiislsYALLGEHLARQGSAYLRWLPWLVALWFLMALVPWFDLITYse 146 Bordetella genomosp. 7
SUV70459  61 FALKCTGGVVLLMALQALWAVNLNRYfsysvilaiglaYMMLGETLARSRSRFLAVLPPLIGFWFILALFPIFDVWTGsq 140 Bordetella avium
O87996   146 RFRMSYPLTGGvwyNINDMATALVFANLIWLLIKRKLSFpLYLTCWFYalamNRRTILLAASVLGLLYLLGYAR 219 Bordetella bronchiseptica
1589230  113 RFRMSYPLTGGvwyNINDMATALVFANLIWLLIKRKLSFpLYLTCWFYalamNRRTILLAASVLGLCCTCWATR 186 Bordetella pertussis
CAP40518 147 RFRARYPLTGGpwdNINNMATALVVANLLWLLARRRLSSaLFAIAWLYclvlNRRADLLGMGVLGAAYLLCLMQ 220 Bordetella petrii
CAA62253 113 RFRMSYPLTGGvwyNINDMATALVFANLIWLLIKRKLSFpLYLTCWFYalamNRRTILLAASVLGLCCTCWATR 186 Bordetella pertussis
EGP46648 128 RFRPEYPLTGGpwdNVNDMGTVLVFVALLWFMIKRRLPAlLFAIVWTYclllNRRADVAALIVFGLAYLLFFMP 201 Achromobacter insuavis AXX-A
KCV35895 142 RFRPGYIMTGGvwdNINDMATVLLFACLIWFLAKGRLSLwLLGGAWLYivalNRRADLAAIILFTGCYLIWLYP 215 Bordetella bronchiseptica...
KDS80790 148 RFRMSYPLTGGvwyNINDMATALVFANLIWLLIKRKLSFpLYLTCWFYalamNRRTILLAASVLGLLYLLGYAR 221 Bordetella bronchiseptica...
CKI24290 143 RFRPRYLLTGGvwnNINDMATALVFANLIWLLCRRRLSLlLFGACWFYalllNRRADMAAALVLGIMYLVWLVD 216 Achromobacter xylosoxidans
AMG38138 146 LFRSSLPITGGvwyNINDMATALVFACLIWLLSRRELPWiLFGAAWIYslglNRRADALALGILGIGYLLLGFK 219 Achromobacter xylosoxidans
SHS02253 148 RFRMSYPLTGGvwyNINDMATALVFANLIWLLIKRKLSFpLYLTCWFYalamNRRTILLAASVLGLLYLLGYAR 221 Mycobacteroides abscessus...
OZI15787 147 RFRARFPLTGGpwdNINNMATALVVVNLLWLLARRRLSLaLFAAGWLYclvlNRRADMLGMMVLGAVYLVFLLE 220 Bordetella genomosp. 7
SUV70459 141 RFRATYILTGGpwdNINDMATVLTLVTLIFTLVKRQVSLpLLAITCFYcvalNRRADLLGLIVFVGGYLLISRD 214 Bordetella avium
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