5VKY


Conserved Protein Domain Family
DLC-like_TDA2
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cd21457: DLC-like_TDA2 
dynein light chain (DLC)-like domain found in topoisomerase I damage affected protein 2 (TDA2) and similar proteins
Topoisomerase I damage affected protein 2 (TDA2) is a novel protein of the endocytic machinery necessary for normal internalization of native cargo in yeast. It works independently of the dynein motor complex and microtubules. The model corresponds to the dynein light chain (DLC)-like domain of TDA2.
Links
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Statistics
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PSSM-Id: 412005
Aligned: 30 rows
Threshold Bit Score: 92.7124
Created: 28-Jan-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
homodimer
Conserved site includes 34 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:5VKY; Saccharomyces cerevisiae TDA2 forms a homodimer, contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        # #                                               ##  ##  ##  #      ###########
5VKY_A        14 IEIKDGRsd----nsPLPERKLVTLIQESYDSlkddnei----nlstesTSNLLIKLVLEKLEKHSSlYKYIASVTTLNI 85  Saccharomyces c...
Q6CU41         5 IKITDNSrel---ngPVSREKLSSILNEIFNKd---------------ePIPSSVELVLAQLNELSSkHKFIVNVTKLNA 66  Kluyveromyces l...
C5DBR4         4 LEVNSVPsss---efPVAPEKLASIIETSARDas-------------sdDLGACTESILVELSKASSaHKFVVSLTKVAF 67  Lachancea therm...
XP_017986972  19 YTVNKEClqsrtesaPFTEERLVQILEGVFSDeeq------------vdDNYDPIKTALERLTEVSSrHKFVVNVTEVRG 86  Eremothecium si...
NP_983358      8 YSVQRGAfga---eaPLTEERLVSLVEQAFEGn---------------gQLGECVEDAVTRLAAASSqHKFVVTATEIRG 69  Eremothecium go...
OEJ84315       4 ISTNNHNid----naPVQPNKIIPMVQDIFQEng--------------yEXGVCCEKLTQSVSEMSSkHKFIVNVTEVKL 65  Hanseniaspora o...
SCU92439       4 IVAENSFige---qrPLDLNDFDKLVNDAFHTsge------------saNAGTVTESILENLTKASSaHKFVVSITSITQ 68  Lachancea miran...
ANZ75142       3 IEETKQInie---slPLEKDLLVEKIKSAVEDpele---------lgpeLVKKLISEILGELTSKSSlHKFFVNVVRIQG 70  Komagataella pa...
XP_013936448   4 LEVDLLNgd----klPVTKTELADQLDTLFKG-----------------DVSEYVENVLAKLTQTSSkYKYVVNAHLIDS 62  Ogataea parapol...
ODV95356       4 IKILSSSqni--dnsPITVHELEAFIQSSVSSstinddeddnsievetfVKTEIIEKLLNKLSAKSSkHKFLINYNLIFE 81  Pachysolen tann...

Feature 1        ##        ##########                             # #
5VKY_A        86 EGlneenanfSLKNDIGASWEsKKDGIFNYKLEDknn----neCYLITILWL 133 Saccharomyces cerevisiae JAY291
Q6CU41        67 NNvnt--adfSVDSYIGSSWNdKSDGAFHYQIPLgsgqpdtkrILLVSVYWI 116 Kluyveromyces lactis NRRL Y-1140
C5DBR4        68 SDsed--fnlSIDSSIGGSWNkTKDGGYSHSVETea-----gaRLLATVVWV 112 Lachancea thermotolerans CBS 6340
XP_017986972  87 TSre----glEISGRLGASWDaVKDGMYNHRVTKgg------sEFLITVLWL 128 Eremothecium sinecaudum
NP_983358     70 AGaa----gqTLQSHAGAAWDgKRDGAHSVRVQRag------sEVLVTVVWL 111 Eremothecium gossypii ATCC 10895
OEJ84315      66 ANkdqnvsdiCVNNSFGTNWDnDKDGVVNCSVIDgeg----grLFMVSVFWI 113 Hanseniaspora osmophila
SCU92439      69 ELldkpasqpTIENFVGGSWDkAKDGLYSTRIEKdq------aTFLVTVIWL 114 Lachancea mirantina
ANZ75142      71 VEgd----nlNICNTSGGHWDqHKDGLLNFKVEVeg------gILMVSIVWL 112 Komagataella pastoris
XP_013936448  63 KEad-----cGIQSFFGAAWNsSTDGTATLKKELdn------gWLVVTIVFL 103 Ogataea parapolymorpha DL-1
ODV95356      82 KNene--nkiNLKNIVGNLWDsERDGYITLTHGIgs-----kiSCILNLNWI 126 Pachysolen tannophilus NRRL Y-2460

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