5X2D,5FWZ,5FX0


Conserved Protein Domain Family
DLC-like_TAL

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cd21454: DLC-like_TAL 
dynein light chain (DLC)-like domain found in the family of tegumental-allergen-like proteins (TALs)
Tegumental-allergen-like proteins (TALs), also called tegument antigens, are characterized by two N-terminal EF-hand motifs and a C-terminal region resembling a dynein light chain (DLC)-like domain. They were mainly found in parasitic platyhelminth species. TALs are strongly associated with the tegument, a syncytial structure that forms the outer layer of the organism. They may be involved in the transport of vesicles within the tegumental cytoplasm, probably within dynein motor complexes. The model corresponds to the dynein light chain (DLC)-like domain of TAL.
Statistics
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PSSM-Id: 412002
Aligned: 43 rows
Threshold Bit Score: 80.3191
Created: 28-Jan-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
homodimer
Conserved site includes 23 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:5X2D; Clonorchis sinensis TAL homodimer interface, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                      #  ##  ##  #          ############### #         
5X2D_A       6 EIIVISANMSLEDQIKIARETIPIapg--aqtSEELGRLTENLKSFADKTFGgCWQVMVVDGSYWITQTFVpnMSFQFEL 83  Clonorchis sinensis
GAA49980   102 QIRVVMATMSRAMQEQIGEDVFFMtr----dsKTSNEHLADRIKRHLDKRFGrTWQVVICQGSSWASFTHLpeTAFFFQL 177 Clonorchis sinensis
CDS17279    78 DIQILNSDMNQKQAESIMLYVVDVir-----rKKSKKDQLEDLKKRLEEVYGrGWNCYMTDGKFYSVCSHEagTSLVFLL 152 Echinococcus gran...
CDS36002   107 QIQVIDREMSEVMMKGILNVTRHAvq----snPGNLQAQAAEIKTYADESYGdTWHCFIVNGSHGYFYSHKpnHSISFFF 182 Echinococcus mult...
VDD83219    60 KVQLIAGDASEEMQKEIINILIRVmr----lyASSSQQLVEQLKIRLDKRFGpIWQCTMIRGAYTTCNAHVpgTNMCFRF 135 Mesocestoides corti
KAA3677134  88 DLLILYEDIDEQDKTNILDKVRSLvre---qaKDDRSKVAAELKRYLDKTYGrCWQVIVTDHSLWANVTCVskYSLHVRL 164 Paragonimus weste...
KAA0197386  88 DVIVLAEDMPFENEKDIVEKTKELka----kyKDNYDVIVKELRDYLELRWEkSWNVVITNDSFWMQISHAmgNSFHFRL 163 Fasciolopsis buski
VDP78323    90 GITILLADAPDNLKDDILKKMAELlg-----sVKSKEDVSNQMKSYLDEKYGrSWVVLLTDDSFWLQAAHMphSSCYCRM 164 Echinostoma caproni
VDN16493     7 ELFLYVYDELAESRVRLRRKDYETfllkwgvdAKKAEELPQEILKRIEPIYGkGWTIYVTDGRVWAMQVHQpgSNLVFAY 86  Dibothriocephalus...
CDS42309    75 ANILYCETTEVVMRRMLMIVEEEIf------kADSQNIQIRGIKNRLDEAFGpNWNCFMARSGCWALKTYKpgTNLVFEY 148 Echinococcus mult...
Feature 1             #  
5X2D_A      84 YNRAYLFWQT 93  Clonorchis sinensis
GAA49980   178 DKNVYLIWKT 187 Clonorchis sinensis
CDS17279   153 NEMVYGVFRT 162 Echinococcus granulosus
CDS36002   183 GGNYYFIFCT 192 Echinococcus multilocularis
VDD83219   136 GDLAFILFKS 145 Mesocestoides corti
KAA3677134 165 GTCCYLLWMT 174 Paragonimus westermani
KAA0197386 164 DDLAFLIWLT 173 Fasciolopsis buski
VDP78323   165 NDICCLVWRT 174 Echinostoma caproni
VDN16493    87 KGNVYGLYQC 96  Dibothriocephalus latus
CDS42309   149 EGMMYDIFQA 158 Echinococcus multilocularis

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