5VKY,1CMI


Conserved Protein Domain Family
DLC-like_SF

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cd21449: DLC-like_SF 
dynein light chain (DLC)-like domain superfamily
The superfamily corresponds to a class of proteins containing a dynein light chain (DLC)-like domain with anti-parallel beta-sheet packed against an alpha-helical hairpin. DLC-like domain-containing proteins includes cytoplasmic dynein light chain DYNLL1 and DYNLL2, axonemal dynein light chain 4 (DNAL4), tegumental-allergen-like proteins (TALs), dynein light chain Tctex-type DYNLT1 and DYNLT3, as well as Tctex1 domain-containing proteins (TCTEX1D). Both DYNLL1 and DYNLL2 are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. DNAL4 is a force generating protein of respiratory cilia. TALs may be involved in the transport of vesicles within the tegumental cytoplasm, probably within dynein motor complexes. DYNLT1 and DYNLT3, which contribute to the differential regulation of dynein cargo binding. They are non-catalytic accessory components of the cytoplasmic dynein 1 complex, which contains either DYNLT1 or DYNLT3, but not both. TCTEX1D family includes TCTEX1D1-4. TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy (DMD). TCTEX1D2 is required for proper retrograde ciliary transport. TCTEX1D3 may be an accessory component of axonemal dynein and cytoplasmic dynein 1. TCTEX1D4 is a novel protein phosphatase 1 (PPP1) interactor.
Statistics
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PSSM-Id: 411997
Aligned: 18 rows
Threshold Bit Score: 40.0139
Created: 30-Sep-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5VKY_A        30 KLVTLIQESYDSlkddnei---------nlstestSNLLIKLVLEKLEKHss------lyKYIASVTtlnieglneenan 94  Saccharomyces c...
1CMI_A        16 DSVECATQALEKyn--------------------iEKDIAAHIKKEFDKKyn-------pTWHCIVGr------------ 56  human
Q22226        66 EIDLIIQKSFDSiigktpys--------pfkmsdwMSKMIQTISDNLVKLng------skKFLVHCTisakt------dn 125 Caenorhabditis ...
Q8N7M0        80 TVNHILKDVVTSylqveeye--------pelcrqmTKTISEVIKAQVKDLmip-----ryKLIVIVHigqln-------r 139 human
XP_001579166  18 QVNEIISRVISGvlksgefv--------pdkvqehLTNILHEVLSQLKELnf------rfKYCVSGLitqnc-------g 76  Trichomonas vag...
XP_008488062  43 KAKEIIRAVLEEefkdkpyd--------gkqsnqiVQKLSKIIKSKVEAVthq-----nyKIVVEVTlveqr-------g 102 Asian citrus ps...
POV94629      34 KIQYILSSKLGItndlsnekesfshsnnqlrlkelNQTIGESIQNLLLEFypt-----gyKIMICTQvienk-------g 101 Puccinia striif...
XP_025425673  49 LIKEIIQNVYGKhlkgktwk--------dldpkitCTNISRDIEYGVVEVyrcirednkyKLVVQTMiceyn-------s 113 yellow sugarcan...
VVC45118      55 LVKQIMHTTHQThldgkkwk--------dldpkmiCTTISNEINDRVKDLcrsirednryKCVVETCiskin-------l 119 Cinara cedri
XP_001582779  20 RAKEIADFILKDifedpqfd--------ynyiqyfLDMASKAITFEIHNDiss-----dfSVFVQVTllenl-------g 79  Trichomonas vag...
5VKY_A        95 fslKNDIGasweskkdgIFNYKLedknnnecYLITILW 132 Saccharomyces cerevisiae JAY291
1CMI_A        57 ---NFGSYvthe--tkhFIYFYLg------qVAILLFK 83  human
Q22226       126 laiCTANMcswdttkdtAYYSEWmsk--tifGAVQVFF 161 Caenorhabditis elegans
Q8N7M0       140 qsiLIGSRclwdpksdtFSSYVFrns--slfALANVYA 175 human
XP_001579166  77 aglYQFASthyeknqdnFANTVYqkg--niiCSVTVYG 112 Trichomonas vaginalis G3
XP_008488062 103 agiRSDLKciwdsdadgLASEVFise--hlvCHASVIA 138 Asian citrus psyllid
POV94629     102 qagRAGLVshwdevsdkVFKEVWsnd--sviGTVTAFI 137 Puccinia striiformis
XP_025425673 114 qsvNIDALcfwdkntdgLVYDSYing--yvvCYSQVYF 149 yellow sugarcane aphid
VVC45118     120 qgvTKKTGclwdlktdkLVSESYine--hllCCSEVII 155 Cinara cedri
XP_001582779  80 qsiISASMslwdqrtddYVATSYstn--kftCLVNIYG 115 Trichomonas vaginalis G3
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