Conserved Protein Domain Family

cd21448: DLC-like_DYNLT1-like 
dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) subfamily and similar proteins
The dynein light chain Tctex-type 1 (DYNLT1) subfamily includes two isoforms, DYNLT1 and DYNLT3, which contribute to the differential regulation of dynein cargo binding. They are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. The dynein complex contains either DYNLT1 or DYNLT3, but not both. The family also includes Schizosaccharomyces pombe dynein light chain Tctex-type (SpDlc1), Saccharomyces cerevisiae topoisomerase I damage affected protein 2 (TDA2) and similar proteins. SpDlc1 belongs to the 14-kDa Tctex-1 dynein light chain family. It acts as a non-catalytic accessory component of a dynein complex. It is required for regular oscillatory nuclear movement and efficient recombination during meiotic prophase in fission yeast. TDA2 is a novel protein of the endocytic machinery necessary for normal internalization of native cargo in yeast. It works independently of the dynein motor complex and microtubules.
PSSM-Id: 411996
Aligned: 5 rows
Threshold Bit Score: 100.981
Created: 23-Mar-2017
Updated: 25-Oct-2021
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
5VKY_A        29 RKLVTLIQESYDSlkddnei--nlstesTSNLLIKLVLEKLEKHss--------lYKYIASVTTLNieglne-------- 90  Saccharomyces c...
5HYC_A        12 NRLKQIAADACNDaigsaefydhakteqWNHQIINTILKAVIAEsqpsdsttppqFKFAVNSTIVQhlvpssklnkpagg 91  Pyricularia ory...
5JPW_A        17 DEVSNIVKEAIESaiggnay-qhskvnqWTTNVVEQTLSQLTKLgk--------pFKYIVTCVIMQkn------------ 75  human
XP_001581163   9 TEMQTRSQKAIQGalndqiy-ddakveeWGSTIVKNVLSEMKELck-------skYKFVTNIMIFSrn------------ 68  Trichomonas vag...
XP_001319796  10 EKIGQICEKNVKHvldgkey-igtqiksWSEEIIRGILQELGKDef-------qpFKYLANCLILSqk------------ 69  Trichomonas vag...
5VKY_A        91 ----------------enanfSLKNDIGASWesKKDGIFNYKLEDknn-neCYLITILWL 133 Saccharomyces cerevisiae JAY291
5HYC_A        92 addkpastatstdgkphvgrrGMHSATGAFWndKTDGMWTYKHEGdeskgmDVVVMLIWI 151 Pyricularia oryzae 70-15
5JPW_A        76 -------------------gaGLHTASSCFWdsSTDGSCTVRWENkt---mYCIVSAFGL 113 human
XP_001581163  69 -------------------kqCIHECQMAYYdnQKDVKITTKWANe----tMQCILSLWG 105 Trichomonas vaginalis G3
XP_001319796  70 -------------------snGVHTVTMSLWdpQNDGSQTYQYSGk----gLQCIVTVWG 106 Trichomonas vaginalis G3
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap