2C5J,2C5I


Conserved Protein Domain Family
SNARE_NTD_Tlg1p-like

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cd21444: SNARE_NTD_Tlg1p-like 
N-terminal domain of t-SNARE affecting a late Golgi compartment protein 1 and similar proteins
t-SNARE affecting a late Golgi compartment protein 1 (Tlg1p), also called syntaxin TLG1, is a soluble NSF attachment protein receptor (SNARE) protein (of Qc type) involved in membrane fusion, probably in retrograde traffic of cytosolic double-membrane vesicles derived from both, early and possibly late endosomes/PVC (prevacuolar compartment) back to the trans-Golgi network (TGN or late Golgi). It has been reported to function both as a (target membrane) t-SNARE and as a (vesicle) v-SNARE. The model corresponds to the N-terminal domain of Tlg1p, which consists of a three-helix bundle.
Statistics
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PSSM-Id: 410570
Aligned: 58 rows
Threshold Bit Score: 62.2098
Created: 6-Feb-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
homodimerVsp51 binding
Conserved site includes 38 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        # ##  #  ##  ## ##  ## ##                    #  #   #   #  #  ##  #  ##         
2C5J_A         6 DPFQQVVKDTKEQLNRINNYITRHNta-------------gdDDQEEEIQDILKDVEETIVDLDRSIIVMKRde------ 66  baker's yeast
ODV91584       2 DPYSQVEADVIEQLETLRNDVYSLErlqgt-------rgpeyDEAVKEAKALIDEVRDTFEDMKVAIETAEGdpsqygvd 74  Tortispora case...
KXS98256      55 DPFQEAQADVLSLLQQTRPLLQSYLrirstas---sanapelREARDELESNLTDLSADLSDLVDSVKAVEGdpyrygld 131 Mycosphaerella ...
CCD47487      44 AIFLCDHIDVHHQLSLTRPLFTSYLrihsltks--phptpelLSARSDLTTSLSLLTDDLQDLRDSISAIQAdpykyglq 121 Botryotinia fuc...
XP_008087767   9 DPFLQVQSEVLQTLSSTRPLFTSYLrirslts---nttnpelLSTARDLSDSIVTLSEDISDLRASVAAVQSdpykygle 85  Glarea lozoyens...
XP_002835069   8 DPFIQFQNELANLLESARTSFSSYLrirtllhtpiappspelLSAQTELRTLLDEISTDLSDLHATVRQMEAdpykfgld 87  Tuber melanospo...
CCX10498       8 DPYIQFQSEVQSLLSSTRASFTNFLrlrsls-----aspsdlTSARHDLSESLTSLSDDLRDLGAAVKAVEKdpykfgld 82  Pyronema omphal...
CCU83005       7 DPFIHVQADVLAQLHQTRSLYTSFLrirslsp---spnspelRSAHSDLSSAIEALSEDLADLLASVQAVQSdpykygle 83  Blumeria gramin...
XP_011111746   5 DPFIQVQQDVTALLHTTRQLFSSYLrirslas---srnspelLSAHSELEGALADLEIDLEDLRLAVSEGERdpyrfgle 81  Dactylellina ha...
XP_002481722   4 DPFLQVQSEVLNTLQTIRPLYSSFLrirsltt---spsnpelVQSRTELESTLEDLQADLADLRQSVRAVERdpyrygle 80  Talaromyces sti...
Feature 1           #  ## ## ### ##  ## ## 
2C5J_A        67 nEDVSGREAQVKNIKQQLDALKLRFD 92  baker's yeast
ODV91584      75 lATIQRRKVKLREYEEQLAELCQPLQ 100 Tortispora caseinolytica NRRL Y-17796
KXS98256     132 vTEVGRRRKLVRDVGGEIEDMRRQMQ 157 Mycosphaerella eumusae
CCD47487     122 iEEVSRRVRMIEEIGGEVDDMREELE 147 Botryotinia fuckeliana T4
XP_008087767  86 iEEVSRRQRFVEEISNEVDDMQEELS 111 Glarea lozoyensis ATCC 20868
XP_002835069  88 iPEVVRRRRFVDEVEGEVGDMREEIN 113 Tuber melanosporum Mel28
CCX10498      83 vSDVASRRRFVEESTGELEDMKEELA 108 Pyronema omphalodes CBS 100304
CCU83005      84 iEEVTRRKRLCDEVRDEVEKMQAQIT 109 Blumeria graminis f. sp. hordei DH14
XP_011111746  82 iEAVAKRRKWLREVEGEISDIKEELG 107 Dactylellina haptotyla CBS 200.50
XP_002481722  81 lDEVERRRGFVQDLGREVDDMVSEIG 106 Talaromyces stipitatus ATCC 10500

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