4DND,2C5J


Conserved Protein Domain Family
SNARE_NTD_STX6-like

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cd21442: SNARE_NTD_STX6-like 
N-terminal domain of syntaxin-6 and similar proteins
The family includes soluble NSF attachment protein receptor (SNARE) proteins, syntaxin-6 (STX6) and syntaxin-10 (STX10), and their homologs found in fungi and plants, such as Tlg1p, AtSYP61, and similar proteins. STX6 is involved in intracellular vesicle trafficking. STX10, also called Syn10, is involved in vesicular transport from the late endosomes to the trans-Golgi network. Tlg1p, also called syntaxin TLG1, is a SNARE protein (of Qc type) involved in membrane fusion probably in retrograde traffic of cytosolic double-membrane vesicles derived from both, early and possibly late endosomes/PVC (prevacuolar compartment) back to the trans-Golgi network (TGN or late Golgi). It has been reported to function both as a (target membrane) t-SNARE and as a (vesicle) v-SNARE. AtSYP61, also called osmotic stress-sensitive mutant 1 (OSM1), is a vesicle trafficking syntaxin protein that functions in the secretory pathway. It is involved in osmotic stress tolerance and in abscisic acid (ABA) regulation of stomatal responses in Arabidopsis.
Statistics
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PSSM-Id: 410568
Aligned: 18 rows
Threshold Bit Score: 64.637
Created: 27-Mar-2017
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4DND_A         27 DPFFVVRGEVQKAVNTARGLYQRWcellqesa----avgreelDWTTNELRNGLRSIEWDLEDLEETIGIVEanpgkf-- 100  human
2C5J_A          6 DPFQQVVKDTKEQLNRINNYITRHnta--------------gdDDQEEEIQDILKDVEETIVDLDRSIIVMKrde----- 66   baker's yeast
Q5KIV8         17 DPYTDLKREVEASLSTIHSLTQNHpdifrk-------ssspeiVQAQDELRGTLSMLETDVEDLEESVRVVEdmgerw-- 87   Cryptococcus ...
XP_002142356    7 DPYNLARGELERNIEKVTKLYEQYkgkvtfvk---nyskkkylADLYDVIVYELYEIEKTISILESTIKTVRahpekf-- 81   Cryptosporidi...
XP_003321391    5 DPYFEVRAEVESSLLSAAALHSSYnrilltlpp-esrptseelSSTRTELKATLSTLIYDISELDHVVRVLEqdlspsss 83   Puccinia gram...
XP_003027628    4 DPYYDLQNEVQASLQTASQLRASYtrirnmav----sqdseelVWARNELKATLATLEADMEDLEGSVQIVEttgarm-- 77   Schizophyllum...
CCA74265        4 DPYVLVQREIQTALDAAEQLRASYarirsta-----rgdseelVVAREELQDALSSLEADLDELEQSVAIVEqsgarm-- 76   Piriformospor...
CCO26675        4 DPWHDVKNEVQNSLEAATNLRASFlriqsta-----sanseelNWARNELKGTLAALDADLEDLEESVRIVEetggrl-- 76   Rhizoctonia s...
XP_014178299    4 DPYTDAKSEVEANIGNLITLLDSYeriksta------pgstslSETVEELQTTLGLLETDLEDLEECVRVVEdhgdrw-- 75   Trichosporon ...
XP_016273570    4 DPYDEVKADVLTSLSQLHQLAGTIsrlsrsgasdplgdgdselHRATAELEANLRTIEPDLEELDESVAAVAepgvaar- 82   Rhodosporidiu...
4DND_A        101 -----------------klpagDLQERKVFVERXREAVQEXKDHXV 129  human
2C5J_A         67 --------------------neDVSGREAQVKNIKQQLDALKLRFD 92   baker's yeast
Q5KIV8         88 -----------------glgtnEVHKRRDFAQRVKREVEMLVKKQD 116  Cryptococcus neoformans
XP_002142356   82 ----------------reisedEIERRIQNIEDYKQIIGEYKLDMK 111  Cryptosporidium muris RN66
XP_003321391   84 ssptsskknnhlnkskfgvsldEVKKRRAWLVEVQQQVQAMKETVE 129  Puccinia graminis f. sp. tritici CRL 75-36-700-3
XP_003027628   78 ----------------fgleeaEVQERRAFVEHVRREIENMRAEVS 107  Schizophyllum commune H4-8
CCA74265       77 ----------------fgiterELITRRRYVSTTRDLLKTMKNEVT 106  Piriformospora indica DSM 11827
CCO26675       77 ----------------fgveeaEVMARRKYVVYVRNQIETMRKEVN 106  Rhizoctonia solani AG-1 IB
XP_014178299   76 -----------------glasaEVRERRIFVDRRLRTQVTAAASLK 104  Trichosporon asahii var. asahii CBS 2479
XP_016273570   83 ----------------lgisdrEVRARHDFVERVKGEVAAIRRQIP 112  Rhodosporidium toruloides NP11
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