Conserved Protein Domain Family
KLF12_N

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cd21441: KLF12_N 
N-terminal domain of Kruppel-like factor 12
Kruppel-like factor 12 (also known as Krueppel-like transcription factor 12, KLF12) regulates, by transcriptionally repressing Nur77 expression, endometrial decidualization, which is a prerequisite for successful implantation and the establishment of pregnancy. It is involved in the maturation processes of kidney collecting ducts after birth, and is able to increase the promoter activity of the UT-A1 urea transporter promoter by binding to the CACCC motif. KLF12 has also been found to promote colorectal cancer growth is also involved in the invasion and apoptosis of basal-like breast carcinoma. KLF12 belongs to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Although these factors bind to similar elements in vitro, they have distinct activities in vivo depending on their expression profile and the sequence of the N-terminal activation/repression domain, which differ between members. KLF12 contains an N-terminal domain that is related to the N-terminal repression domain of KLF8.
Statistics
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PSSM-Id: 410608
Aligned: 9 rows
Threshold Bit Score: 264.177
Created: 15-Jan-2020
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9Y4X4        27 PAVRVKTELLESEQGSPNVHNYPDMEaVPLLLNNVKGEPPEDSLSVDHFQTQTEPVDLSINKARTSPTAVSSSPvsmtas 106 human
NP_034766     27 PAVRVKTELVESEQGSPNVHNYPDMEaVPLLLNNVKGEPPEDSLPVDHFQTQTEPVDLSINKARTSPTAASSSPvsmtas 106 Mus musculus
XP_007888930  33 PAARVKAEQLESEQGSPPATNYADMDaVPVLLNNVKAEPPEDLLSTDQYQTQTEPVDLSINKARISPTAVSSSQsspssm 112 Callorhinchus m...
XP_003640604  23 PAVRVKTELLESEQGSPNVHNYPDMEaVPLLLNNMKADPPEDSLSADHFQTQTEPVDLSINKARSSPTAASSSPvsmtas 102 Gallus gallus
XP_006007328  38 PAVRVKTELVETERRSPIVRNCTEIDaVPLLLNNVKAEPPEDLLSTDHFQAQTEPVDLSINKARTSPSAVSSSPtssal- 116 Latimeria chalu...
NP_009180     27 PAVRVKTELLESEQGSPNVHNYPDMEaVPLLLNNVKGEPPEDSLSVDHFQTQTEPVDLSINKARTSPTAVSSSPvsmtas 106 Homo sapiens
XP_007501503  27 PAVRVKTELLESEQGSPNVHNYPDMEaVPLLLNNMKTEPPEDSLSTDHFQTQTEPVDLSINKARTSPTAVSSSPvsmtas 106 Monodelphis dom...
O35738        27 PAVRVKTELVESEQGSPNVHNYPDMEaVPLLLNNVKGEPPEDSLPVDHFQTQTEPVDLSINKARTSPTAASSSPvsmtas 106 house mouse
XP_018102774   8 PAVRVKTELLESEQRSPNVHTYPDMEaVPLLLNSVKAEPPEDLLSTDHFQTQTEPVDLSINKARTSPRGVSSSPvsitts 87  African clawed ...
Q9Y4X4       107 as-spsststSSSSSSRLASSPTVITs-vSSASSSSTVLtPGPLVASASGVGGQQFLHIIHPVPPSSpmnlQSNKLSHVH 184 human
NP_034766    107 as-spsststSSSSSSRPASSPTVITs-vSSASSSSTVLsPGPLVASASGVGGQQFLHIIHPVPPSSpmnlQSNKLSHVH 184 Mus musculus
XP_007888930 113 t---ttsicsTSSSSPRLTSSPTVITsvgSSATGMPTVLgPGSIVASTPGVGGQQYLHIIHPVPSSNpmnfQSNKLSHMH 189 Callorhinchus m...
XP_003640604 103 a--sspsstsTSSSSSRPASSPTVITs-vSSAASVPSVLsPGPLVASASGVGGQQFLHIIHPVPPSSpmnlQSNKMSHVH 179 Gallus gallus
XP_006007328 117 ------tsspSSSSSSRPASSPSVIAt-aSSASTVPTVL-PGSLMASASGVRGQQFLHIIHPVPPSSpinlQSSKLSQVH 188 Latimeria chalu...
NP_009180    107 as-spsststSSSSSSRLASSPTVITs-vSSASSSSTVLtPGPLVASASGVGGQQFLHIIHPVPPSSpmnlQSNKLSHVH 184 Homo sapiens
XP_007501503 107 asspsststsSSSSSSRPASSPTVITs-vSSASSAPTVLtPGPLVASASGVGGQQFLHIIHPVPPSSpmnlQSNKLSHVH 185 Monodelphis dom...
O35738       107 as-spsststSSSSSSRPASSPTVITs-vSSASSSSTVLsPGPLVASASGVGGQQFLHIIHPVPPSSpmnlQSNKLSHVH 184 house mouse
XP_018102774  88 -----aaspsSNSSSSRPASSPTVITp-vPSSASVPTVLtPGPLVASASSIGGQQFLHIIHPVPPASplnlQSNKLSHVH 161 African clawed ...
Q9Y4X4       185 RIPVVVQSVPVVYTAVRSPGNvnNTIVVPLLeDGRGHGKA 224 human
NP_034766    185 RIPVVVQSVPVVYTAVRSPGNvnNTIVVPLLeDGRSHGKA 224 Mus musculus
XP_007888930 190 RIPVVVQSLPLVYTAMRSQGNlnSTIVLPMIeDGRTQLKV 229 Callorhinchus milii
XP_003640604 180 RIPVVVQSVPVVYTAVRSPGNmnNTIVVPLLeDGRSHVKA 219 Gallus gallus
XP_006007328 189 RIPVVVQSVPVVYTAVRSPGNlnSTIVVPLLeEGRNHGKA 228 Latimeria chalumnae
NP_009180    185 RIPVVVQSVPVVYTAVRSPGNvnNTIVVPLLeDGRGHGKA 224 Homo sapiens
XP_007501503 186 RIPVVVQSVPVVYTAVRSPGNmnNTIVVPLLeDGRSHVKA 225 Monodelphis domestica
O35738       185 RIPVVVQSVPVVYTAVRSPGNvnNTIVVPLLeDGRSHGKA 224 house mouse
XP_018102774 162 RIPVVVQSVPVVYTAVRSPGNmnSTIVVPLLeDGRGHLKA 201 African clawed frog
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