Conserved Protein Domain Family

cd21396: GINS_B 
beta-strand (B) domain of GINS complex proteins: Sld5, Psf1, Psf2, Psf3, Gins51 and Gins23
The GINS (named from the Japanese go-ichi-ni-san, meaning 5-1-2-3 for the Sld5, Psf1, Psf2, and Psf3 subunits) complex is involved in both the initiation and elongation stages of eukaryotic chromosome replication, with GINS being the component that most likely serves as the replicative helicase that unwinds duplex DNA ahead of the moving replication fork. This complex is found in eukaryotes and archaea, but not in bacteria. In eukaryotes, GINS is a tetrameric arrangement of four subunits Sld5, Psf1, Psf2 and Psf3, while in archaea, it consists of two different proteins named Gins51 and Gins23. The archaeal GINS complex can be either an alpha2beta2-type heterotetramer composed of Gins51 and Gins23, or a Gins51-only alpha4-type homotetramer. All GINS subunits are homologous and consist of two domains, called the alpha-helical (A) and beta-strand (B) domains. The A and B domains of Sld5/Psf1/Gins51 are permuted with respect to Psf1/Psf3/Gins23. The overall tetrameric assemblies of GINS are similar, but the relative locations of the C-terminal small domains are different with respect to the alpha-helical domain, resulting in different subunit contacts. However, the basic function of GINS in DNA replication is conserved across eukaryotes and archaea. This model represents the beta-strand domain (B-domain) of GINS complex proteins.
PSSM-Id: 412027
Aligned: 6 rows
Threshold Bit Score: 42.8363
Created: 30-Sep-2020
Updated: 25-Oct-2021
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
2Q9Q_B 170 YVFLRVRERQEnilvepdtd-eqrdyvidLEKGSQHLIRYKTIAPLVAs--GAVQLI 223 human
3ANW_B  14 LIAVKVMKPFGd-----------------WKSGDIVLVEDWKARELWEa--GVVEIV 51  Thermococcus kodakarensis
3ANW_A 136 KEAYIIQIDLPavlgpd------mkeygpFMAGDMAIIPTVIGRALVEr--EAARRV 184 Thermococcus kodakarensis
2Q9Q_D  35 KLPVRTETAMPrlgafflersagaetdnaVPQGSKLELPLWLAKGLFDnkrRILSVE 91  human
2E9X_B  14 LVTIIPNFSLDkiylig-------gdlgpFNPGLPVEVPLWLAINLKQr--QKCRLL 61  human
3JC5_A 162 FIDVRVLKDAGeiqte--------ygvfnLIKDSQFFVQQSDVERLIQq--GYLQLI 208 baker's yeast
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