6HFO


Conserved Protein Domain Family
CTWD_Cns1
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cd21380: CTWD_Cns1 
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C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and similar proteins
Cns1, also called cyclophilin seven suppressor 1, or STI1 stress-inducible protein homolog, binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). It stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. It is involved in only a subset of Hsp90 functions. The model corresponds to Cns1 C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices.
Links
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Statistics
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PSSM-Id: 439174
Aligned: 115 rows
Threshold Bit Score: 149.245
Created: 7-Feb-2020
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6HFO_A         4 EALLQAIKARNIRLSEaacededsaseglgelfldglstenphGARLSLDGq--GRLSWPVLFLYPEYAQSDFISAFHED 81  human
XP_018914318 234 KKLIAAINERNIKIYPetkgltsmsq--------lepcfpevvQKTVHFEN---DRLVWPVIFLYPEYGTTDFIQEFHED 302 Bemisia tabaci
XP_019874537 231 KRVIQEIVKRGIRIETgkgglslss---------lepcapqlsENRVHIDDe--NNLIWPVVFLYPEYKIMDYVQEFNEN 299 small hive beetle
XP_004534593 257 IRLVKALEERGVKFVKegkrapitek--------ilqsasgmaGHTVHLDEydnKTLVWSLAFLYPKFSIGDYQVDIHED 328 Mediterranean f...
XP_021929521 182 QALLTAIKERGIQIKGtdlsmstl-----------epcspmvaQGRVHLDDs--GSLVWPVMFLYPEYQVTDFVQEFHED 248 Zootermopsis ne...
XP_023217001 226 RKLKQAIMERGIKIKPrmphlepewdi------hdletshpaaKQNVHLDKd--NNLIWPVYFLYPEFAEMDFIQEFGEN 297 bark scorpion
XP_026475205 230 KTTVEILNERKIKFFDkkllcgdlky-------vpqpnyepilKNPINVKN---NILHWPILFLYPEYLTIDCLQSVPEA 299 cat flea
XP_029851011 222 AALRSALAERGIKVPEaeeeaaeale-------rltpthpalqSHRVHLSDd-gADLVWPAVFLYPETMESDFVQQFDER 293 black-legged tick
A1Z6M6       232 HRLRDAIEQRAIKFDDqkvgkkdvlse-----ellypkflpleDHPVHLDEd-gSTLIWPAAFSYPEFLYSDFYQQLPET 305 fruit fly
XP_031640215 245 KRTIEELKSRNIRFEEqletsayedl--------ikpsylpleEYPIQITDv--GQLRWPAVFCYPEFEICDFQQQIYDN 314 swede midge

6HFO_A        82 SRFIDHLMVMFGEt---pSWDlEQKYCPdNLEVYFEDEdrAELYRVPAKSTLLQVLQHqryfVKALTPAFLVCVgsspFC 158 human
XP_018914318 303 SRFEDHIAEMFQTa---pEWDtNGQYTPdKIRIYFEDFd-HNAHRVSPESTLNQAISHpkyrVDGGVPAFIIVVdgslTE 378 Bemisia tabaci
XP_019874537 300 QTFEALFEDMFSVr---pEWDvDNKYKTnSLVIYFETGn-NKLISVNRTATLVDVLKHkeyvVKGGTPSFLVLVnessAH 375 small hive beetle
XP_004534593 329 ALMETCVSQLFEEp---lPWDrRGFYREdNVNVYYEDAttHQVHLVDLKKTVGEISVEktfyVTQNGLEFYVLKkdsrEE 405 Mediterranean f...
XP_021929521 249 NTFSQHLSTMFESp---pEWDkDSSYILsELNIYYECQsdRTLHPVDACDTLGQVLPKqsyvVCGGTPCFLVTVrgskAE 325 Zootermopsis ne...
XP_023217001 298 TRFFDHLKVMFGSpenrpEWDkTNSYIPeKLQIYFEYSeeDCLVSVNKNSTLQEILRDdrywVKNGTPAFIIMVqnseFE 377 bark scorpion
XP_026475205 300 TTINDNLQEIFGEk---pDWDvKNEYKPeNLNAYFENRylGQVFLLSKTLTLEQITTQknfiVYDGALSFYIVPkdsqAE 376 cat flea
XP_029851011 294 STFGEQTDVLFGDpgnqpEWNaDGRYAPgKVTVWFKHKlsGVPVPVLPTCTLKEIILDkrfqVDNGTPSFWVLPkgsaYE 373 black-legged tick
A1Z6M6       306 TTMRDCLATLLTEk---lPYDkAHNYRLgNVHVYYENRkvGCVHKVDEEKQLAEIIAEkgffVSGGALLFYVVHkdsrVE 382 fruit fly
XP_031640215 315 NTIYDILCDLFSEr---mPQDkTYKYKPdTVNVYFENRikATIHQVDVRKTIKEITSDknflVGRGILTFHVVTkstdAE 391 swede midge

6HFO_A       159 KNFLR 163 human
XP_018914318 379 KRLLS 383 Bemisia tabaci
XP_019874537 376 KRFLE 380 small hive beetle
XP_004534593 406 REFLS 410 Mediterranean fruit fly
XP_021929521 326 CCLLA 330 Zootermopsis nevadensis
XP_023217001 378 KDFRG 382 bark scorpion
XP_026475205 377 KDFVN 381 cat flea
XP_029851011 374 ARFLR 378 black-legged tick
A1Z6M6       383 QEFIN 387 fruit fly
XP_031640215 392 KRFLA 396 swede midge
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