2E62


Conserved Protein Domain Family
cwf21
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cd21369: cwf21 
cwf21 domain
The cwf21 domain is involved in mRNA splicing; it binds directly to the spliceosomal protein Prp8. Mutations in the cwf21 domain prevents its binding to Prp8. The domain is composed of two alpha helices. Proteins containing the cwf21 domain include complexed with CEF1 protein 21 (CWC21) from budding yeast, complexed with cdc5 protein 21 (CWF21) from fission yeast, as well as their orthologs, serine/arginine repetitive matrix proteins (SRRM2 and SRRM3) from vertebrates. This domain family also includes U2-associated protein SR140 from Eumetazoa, protein RRC1, and similar proteins from plants.
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Statistics
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PSSM-Id: 410596
Aligned: 4 rows
Threshold Bit Score: 38.9898
Created: 28-Mar-2017
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2E62_A   10 MDEEQRQKRRRIEVALIEYRETLEEQgm--kNPEEIERKVEINRKRLEVD 57   thale cress
O15042  836 MSEEKRAKLREIELKVMKFQDELESGkrpkkPGQSFQEQVEHYRDKLLQR 885  human
Q03375   62 KQIETHMEKREIEVQVSELRDRLEEEet--lSEEQIDKKCEALRAKLTNE 109  Saccharomyces cerevisiae S288C
Q9UQ35   55 PDILDHERKRRVELRCLELEEMMEEQg---yEEQQIQEKVATFRLMLLEK 101  human
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